Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"muscarinic receptors"”.
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MOLECULAR MODIFICATION OF SOME ATROPINE-LIKE ANTICHOLINERGICS AS PROBES FOR MUSCARINIC RECEPTORS.
… ATROPINE-LIKE ANTICHOLINERGICS AS PROBES FOR MUSCARINIC RECEPTORS.
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Effects of blockade of muscarinic receptors in the ventral tegmental area : attenuation of cocaine reward, but enhancement of locomotor activity and dopamine overflow in the nucleus accumbens
… Bilateral intracranial injections of the muscarinic receptor antagonist atropine into the ventral tegmental area attenuated the rewarding effects of intravenous cocaine self-administered on either fixed ratio or progressive ratio schedules of reinforcement. Low doses of atropine sulphate, …
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Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry
… series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine hydrobromide, bexarotene, disila-bexarotene, and disila-AG-045572 (disila-CMPD1) are included. …
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Neurochemical Effects of Concurrent Exposure to Repeated Stress and Chlorpyrifos on the Central Nervous System
… rate constant (Kd) of NMDA and total muscarinic receptors were studied in Long-Evans rats. The study was divided into 4 experiments. The first experiment was to find the dose of CPF to use for studies on the interaction of stress and CPF. From the results obtained, 60% of the maximum …
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Adrenergic-cholinergic interactions in the heart
In the mammalian atrial myocardium the muscarinic receptor agonist carbacholcan inhibit the positive inotropic responses to isoproterenol, a f3-adrenoceptor agonist, forskolin, a direct activator of adenylate cyclase, IBMX, a phosphodiesterase inhibitor, and phenylephrine, an a-adrenoceptor …
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CHOLINERGIC CONTRIBUTIONS TO EMOTION REGULATION
… and neuroanatomical studies implicate the muscarinic cholinergic system in normal and pathological emotion regulation. Emotional and sensory experiences can be induced with intravenous administration of the local anesthetic procaine hydrochloride, which selectively activates limbic regions …
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Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens
… cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 …
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Prediction of In-Vivo Antimuscarinic Activity (AMA) by In-Vitro Receptor Binding Assessment and PK/PD Modeling For Prototypical Drugs
Purpose: To establish a tool, termed as antimuscarinic activity (AMA), to predict the incidence of antimuscarinic adverse events (AMAEs).Methods: A literature review, focused on drugs having off-target interaction with muscarinic receptors, was performed. Prototypical drugs olanzapine, …
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Cholinergic Control of Cortical Circuit Activity
… reliant on the engagement of both nicotinic and muscarinic acetylcholine receptors. Nicotinic receptors mediated transient suppression by acting in the superficial cortical layers, while muscarinic receptors mediated prolonged suppression in layer 4. In agreement, we found nicotinic-mediated …
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Blockade of Acetylcholine Receptors by Cobra Toxin Electrophysiology and Pharmacology
… inactivates postsynaptic acetylcholine (ACh) receptors. Raja and Torpedo electroplaques also show nicotinic pharmacology and were similarly affected by the toxin. The toxin failed to affect the muscarinic receptors of the isolated frog heart or the receptors of Aplysia neurons (neither …
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Intrinsic Properties and Neuromodulator Regulation of Neuronal Excitability of Intralaminar Thalamic Neurons
… on rat parafascicular nucleus neurons. The muscarinic receptor agonist, acetyl-beta-methylcholine (MCh), hyperpolarized the majority of neurons by increasing a resting potassium conductance via the activation of M2 muscarinic receptors. In a smaller population, MCh, via M1 muscarinic …
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Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of
… midVTA. This carbachol-induced AA is mediated by muscarinic receptors within the pVTA and by both muscarinic and nicotinic receptors within the aVTA. Using the conditioned place preference paradigm (CPP), the present study evaluated the muscarinic versus nicotinic involvement in intra-VTA …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… acetylcholine (ACh). Two types of acetylcholine receptors (AChRs) have been suggested to be located on hair cells (HCs). They were nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs). Even though pioneering physiological and pharmacological studies have shown evidence of mAChR located …
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Neuronal plasticity in the enteric nervous system motor pathways
… not yet known. Acetylcholine acting on nicotinic receptors mediates the majority of fast synaptic transmission between enteric neurons, however, recent studies suggest that the peristaltic motor pattern can occur during nicotinic receptor blockade. The aim of this thesis was to determine if …
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A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor
<p>Muscarinic acetylcholine receptors (MRs), a family of five G protein-coupled receptors (GPCRs), play an essential role in the regulation of mammalian physiology. In the brain, MR-mediated neurotransmission is required for the control of movement and motivated behavior by the basal ganglia, and …
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The M(1) muscarinic receptor and its second messenger coupling in human neuroblastoma cells and transfected murine fibroblast cells
… indicate that pirenzepine(PZ)-high affinity muscarinic receptors (mAChRs) are coupled to the hydrolysis of inositol lipids and not to the adenylate cyclase system in human neuroblastoma SH-SY5Y cells. The maximal carbachol(CCh)-stimulated [³H]IP₁ accumulation in the SH-SY5Y cells was …
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Studies into the effects of gonadectomy on the canine urinary bladder with reference to acquired urinary incontinence in the bitch
… disease. Contractility in response to carbachol (muscarinic) and electrical field stimulation was assessed in isolated strips of detrusor muscle from male and female, intact and gonadectomised canines. The potential role of non-adrenergic, non-cholinergic mediated contraction of the detrusor …
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Carbachol-Induced Pigment Granule Dispersion
… apical processes that interdigitate with photoreceptors. In teleosts, the RPE aids in light adaptation through pigment granule movements. In the bright light, pigment granules are dispersed into the long apical processes thereby shielding rods from excessive light. The opposite occurs in dark …
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GPCR to Channel Communication in a Membrane Signaling Pathway
<p>G-protein-coupled receptors (GPCRs) regulate a variety of downstream effector proteins, making them essential for many physiological processes. For example, in the heart, the activation of beta-adrenergic receptors (βARs) and the stimulatory G protein (Gαs) leads to the opening of downstream …
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Understanding the impacts of antipsychotic pharmaceuticals on behaviour in fish
… monoaminergic, adrenergic, histaminergic, and muscarinic receptors expressed in neural and peripheral tissues across taxa. Despite these risks, APDs remain understudied compared to other neuroactive pharmaceutical classes (e.g. antidepressants), with their ecological implications on complex …
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