Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"muscarinic receptor"”.
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Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens
… cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 …
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Conformationally-restricted analogs of selected anticholinergic agents as probes for the muscarinic receptor.
… anticholinergic agents as probes for the muscarinic receptor.
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The M(1) muscarinic receptor and its second messenger coupling in human neuroblastoma cells and transfected murine fibroblast cells
… indicate that pirenzepine(PZ)-high affinity muscarinic receptors (mAChRs) are coupled to the hydrolysis of inositol lipids and not to the adenylate cyclase system in human neuroblastoma SH-SY5Y cells. The maximal carbachol(CCh)-stimulated [³H]IP₁ accumulation in the SH-SY5Y cells was …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… contractions are mainly dependent on muscarinic receptor activation in the newborn whereas adult bladders are equally dependent on muscarinic and purinergic receptor activation. Muscarinic receptor-induced contractions are due to activation of the M3 subtype in both adults and …
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Postsynaptic Cholinergic Control Of Cardiac Function In Aging
… rats. (ii) No age-related difference was seen in muscarinic receptor number in the atria and ventricles as assessed by {dollar}lbracksp3rm Hrbrack QNB{dollar} binding, but the muscarinic receptor binding affinity for carbachol, a cholinergic agonist, was increased in the atria but not ventricles …
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Carbachol-Induced Pigment Granule Dispersion
… apical processes that interdigitate with photoreceptors. In teleosts, the RPE aids in light adaptation through pigment granule movements. In the bright light, pigment granules are dispersed into the long apical processes thereby shielding rods from excessive light. The opposite occurs in dark …
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Novel interactions of the 5-HT₂ₐ and related receptors with intracellular signalling proteins
… signalling mechanisms of the 5-HT₂ₐ and related receptors. The Gprotein coupled receptors (GPCRs) are named after their ability to interact with and signal through the trimeric G-proteins. The 5-hydroxytryptamine 2A receptor (5- HT₂ₐR) is a member ofthe group I family of rhodopsin-related GPCRs. …
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Intrinsic Properties and Neuromodulator Regulation of Neuronal Excitability of Intralaminar Thalamic Neurons
… on rat parafascicular nucleus neurons. The muscarinic receptor agonist, acetyl-beta-methylcholine (MCh), hyperpolarized the majority of neurons by increasing a resting potassium conductance via the activation of M2 muscarinic receptors. In a smaller population, MCh, via M1 muscarinic …
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Adrenergic-cholinergic interactions in the heart
In the mammalian atrial myocardium the muscarinic receptor agonist carbacholcan inhibit the positive inotropic responses to isoproterenol, a f3-adrenoceptor agonist, forskolin, a direct activator of adenylate cyclase, IBMX, a phosphodiesterase inhibitor, and phenylephrine, an a-adrenoceptor …
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MUSCARINIC ACETYLCHOLINE M2 RECEPTORS INCREASE IN CHOLINERGIC INTERNEURONS OF THE NUCLEUS ACCUMBENS FOLLOWING BINGE ALCOHOL DRINKING IN C57BL/6J MICE
… cholinergic neurons are shown to possess muscarinic M2 receptors that autoregulate acetylcholine release. The study presented in this thesis examined the effect of binge alcohol drinking on muscarinic M2 autoreceptors on accumbal cholinergic interneurons. The present findings report an …
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Comparison of Ecto-Nucleotidase Activity in PAR-C5 Cells and Native Rat Parotid Gland
… the native cells. Further studies showed that muscarinic receptor stimulation and inhibition had no effect on ecto-nucleotidase activity indicating that the enzyme was stable under a variety of cell activities. The results indicate that PAR-C5 cells maintain ecto-nucleotidase after …
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Brainstem cholinergic modulation of the limbic learning circuit
… Experiment 1, local injections of a cholinergic muscarinic receptor blocker, scopolamine, in the AV nucleus reduced avoidance responding and the amplitude of cingulate cortical excitatory TIA in rabbits trained to asymptotic performance. In Experiment 2, bilateral lesions in the brainstem …
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Association Study of CHRM2 Polymorphisms with Substance-Use Pathology and Personality Traits
… of CHRM2 (the gene coding for cholinergic muscarinic receptor 2) with alcohol dependence (Wang et al., 2004), with the broader phenotype of substance dependence in general (Luo et al., 2005; Dick, Agrawal, et al., 2007), and with the still-broader phenotype of externalizing psychopathology …
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Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… to the basal membrane of the crypts, where the muscarinic receptor (M3AchR) was expressed. Fura-2 Ca2+ imaging demonstrated that Carbachol (Cch) evoked Ca2+ signals at the human colonic crypt base via M3AchR activation, which then spread to all cell types along the crypt-axis. Surprisingly, …
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Integration of signalling in smooth muscle caveolae
… of human bladder strips in response to muscarinic receptor activation. I then demonstrate that the membrane density of caveolae increases after bladder outlet obstruction in the rat. The latter effect was due to crowding of the same relative number of caveolin molecules on a smaller …
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TRPM5 Channels Contribute to Persistent Neural Activity and Working Memory
… This firing behavior is linked to cholinergic muscarinic receptor activation and phospholipase C (PLC) signaling in the absence of synaptic reverberations. Two fundamental questions are: (1) What mechanism underlies the generation of sustained firing at a single cell level? (2) What role does …
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Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
… treated with TSA and AZA increased expression of muscarinic receptor 3, myosin light chain kinase 2, and showed an increased response to carbachol stimulation. TSA and AZA treatment also increased GDNF expression, and improved the neurotrophic function of repeated passage ISMC. Compared to low …
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Effects of blockade of muscarinic receptors in the ventral tegmental area : attenuation of cocaine reward, but enhancement of locomotor activity and dopamine overflow in the nucleus accumbens
… Bilateral intracranial injections of the muscarinic receptor antagonist atropine into the ventral tegmental area attenuated the rewarding effects of intravenous cocaine self-administered on either fixed ratio or progressive ratio schedules of reinforcement. Low doses of atropine sulphate, …
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The Role of Calcium in Signal Transduction: Kinetics and Regulation of Intracellular Calcium During the Photomechanical Response of the Albino Rat Sphincter Pupillae Smooth Muscle
… transduction cascade for agonist activation is receptor → G-protein → phospholipase C → inositol trisphosphate → intracellular calcium → calcium-calmodulin complexes → myosin light chain kinase → phosphorylated myosin → force. In the isolated vertebrate …
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Oligodendrocyte precursor cell states and their regulation
… voltage-gated ion channels and neurotransmitter receptors. Functional expression of these channels and receptors is often described as a defining feature of OPCs, although several reports suggest that OPCs exhibit diversity in their electrophysiological properties. In this thesis, I investigate …
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