Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"muscarinic"”.
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FRET-Based Conformational Sensor for the m1 Muscarinic Cholinergic Receptor
… an optical conformational sensor for the m1 muscarinic cholinergic receptor (M1), a prototypical G protein-coupled receptor (GPCR), to study how receptor activity is regulated by the coordinated action of agonist, G protein and GAP. To create the sensor, I adopted an underlying design …
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Muscarinic cholinergic receptors in the developing and mature basal ganglia
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1988.
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Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation
Wray, David Walter, Peripheral and Central Muscarinic Cholinergic Receptors in Arterial Blood Pressure Regulation. Master of Science (Biomedical Sciences), December, 1999, 70 pp., 7 tables, 8 illustrations, references, 83 titles. This study was designed to test the hypothesis that an age-related …
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Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that mediate important functions in the periphery and in the central nervous systems. In the brain these receptors modulate many processes including learning, locomotion, pain, and reward behaviors. In this work we …
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MOLECULAR MODIFICATION OF SOME ATROPINE-LIKE ANTICHOLINERGICS AS PROBES FOR MUSCARINIC RECEPTORS.
… ATROPINE-LIKE ANTICHOLINERGICS AS PROBES FOR MUSCARINIC RECEPTORS.
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A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor
<p>Muscarinic acetylcholine receptors (MRs), a family of five G protein-coupled receptors (GPCRs), play an essential role in the regulation of mammalian physiology. In the brain, MR-mediated neurotransmission is required for the control of movement and motivated behavior by the basal ganglia, and …
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Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens
… through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 subtype on macrophages has potent anti-inflammatory effects. However, the role for muscarinic receptor has not yet been conclusively …
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Conformationally-restricted analogs of selected anticholinergic agents as probes for the muscarinic receptor.
… anticholinergic agents as probes for the muscarinic receptor.
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NOVEL HETEROCYCLIC RING SYSTEMS DERIVED FROM CARACURINE V AS LIGANDS FOR THE ALLOSTERIC SITE OF MUSCARINIC M 2 RECEPTORS
Die vorliegende Arbeit befasst sich mit dem Gebiet allosterischer Modulation des muscarinischen M2 Rezeptors. Allosterische Liganden beeinflussen das Bindungsverhalten eines orthosterischen Liganden (Agonisten oder Antagonisten) an die klassische Bindungsstelle des muscarinischen Rezeptors, indem …
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The M(1) muscarinic receptor and its second messenger coupling in human neuroblastoma cells and transfected murine fibroblast cells
… indicate that pirenzepine(PZ)-high affinity muscarinic receptors (mAChRs) are coupled to the hydrolysis of inositol lipids and not to the adenylate cyclase system in human neuroblastoma SH-SY5Y cells. The maximal carbachol(CCh)-stimulated [³H]IP₁ accumulation in the SH-SY5Y cells was …
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MUSCARINIC ACETYLCHOLINE M2 RECEPTORS INCREASE IN CHOLINERGIC INTERNEURONS OF THE NUCLEUS ACCUMBENS FOLLOWING BINGE ALCOHOL DRINKING IN C57BL/6J MICE
… cholinergic neurons are shown to possess muscarinic M2 receptors that autoregulate acetylcholine release. The study presented in this thesis examined the effect of binge alcohol drinking on muscarinic M2 autoreceptors on accumbal cholinergic interneurons. The present findings report an …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… contractions are mainly dependent on muscarinic receptor activation in the newborn whereas adult bladders are equally dependent on muscarinic and purinergic receptor activation. Muscarinic receptor-induced contractions are due to activation of the M3 subtype in both adults and …
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Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
Muscarinic acetylcholine receptors (mAChRs) are G-protein-coupled receptors that are underutilized for controlling insect pests despite their involvement in various physiological functions. To-date, there are no commercialized insecticides targeting insect mAChRs. In this dissertation, effective …
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CHOLINERGIC CONTRIBUTIONS TO EMOTION REGULATION
… and neuroanatomical studies implicate the muscarinic cholinergic system in normal and pathological emotion regulation. Emotional and sensory experiences can be induced with intravenous administration of the local anesthetic procaine hydrochloride, which selectively activates limbic regions …
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Effects of blockade of muscarinic receptors in the ventral tegmental area : attenuation of cocaine reward, but enhancement of locomotor activity and dopamine overflow in the nucleus accumbens
… Bilateral intracranial injections of the muscarinic receptor antagonist atropine into the ventral tegmental area attenuated the rewarding effects of intravenous cocaine self-administered on either fixed ratio or progressive ratio schedules of reinforcement. Low doses of atropine sulphate, …
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Cholinergic Control of Cortical Circuit Activity
… reliant on the engagement of both nicotinic and muscarinic acetylcholine receptors. Nicotinic receptors mediated transient suppression by acting in the superficial cortical layers, while muscarinic receptors mediated prolonged suppression in layer 4. In agreement, we found nicotinic-mediated …
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Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry
… series of silicon-based allosteric modulators of muscarinic receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine hydrobromide, bexarotene, disila-bexarotene, and disila-AG-045572 (disila-CMPD1) are included. …
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Adrenergic-cholinergic interactions in the heart
In the mammalian atrial myocardium the muscarinic receptor agonist carbacholcan inhibit the positive inotropic responses to isoproterenol, a f3-adrenoceptor agonist, forskolin, a direct activator of adenylate cyclase, IBMX, a phosphodiesterase inhibitor, and phenylephrine, an a-adrenoceptor …
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Neurochemical Effects of Concurrent Exposure to Repeated Stress and Chlorpyrifos on the Central Nervous System
… rate constant (Kd) of NMDA and total muscarinic receptors were studied in Long-Evans rats. The study was divided into 4 experiments. The first experiment was to find the dose of CPF to use for studies on the interaction of stress and CPF. From the results obtained, 60% of the maximum …
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Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of
… midVTA. This carbachol-induced AA is mediated by muscarinic receptors within the pVTA and by both muscarinic and nicotinic receptors within the aVTA. Using the conditioned place preference paradigm (CPP), the present study evaluated the muscarinic versus nicotinic involvement in intra-VTA …
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