Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 193 for “"murine models"”.
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Molecular Regulation of Vascular Calcification In Murine Models of Atherosclerosis
<p><strong>Background</strong>: Calcification occurs often in the atherosclerotic lesions of patients with coronary heart disease and animals with hypercholesterolemia, such as apolipoprotein-E deficient (ApoE-/-) mice. However, the mechanism(s) underlying the development of calcification in …
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Role of Nlc Cells in Murine Models of T Cell-Dependent Responses
NK cells are part of the innate immune system, yet they can also modulate the acquired immune response. Activated NK cells, for instance, can increase antigen specific IgG2a production in response to T independent responses, mostly through IFN-gamma secretion. Previous experiments examining the …
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Assessing the temporal role of miR-200 loss in murine models of NSCLC
… autochthonously in mouse lungs, creating models with distinct metastatic potentials. Mice with loss of miR-200 had detectable distant metastases earlier than their cohorts where miR-200 was left intact. Based on survival and metastatic data, a time point of 16 weeks was chosen to examine …
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Autoimmune Responses to Atherosclerotic Lipids: A Study In Murine Models of Atherosclerosis and Obesity
… proinflammatory signaling was evaluated in murine models. Enhanced CD1 expression occurred in spleens of db/db mice with hyperlipidemia. Tumor necrosis factor-alpha (TNF-α) was increased in db/db spleen, while TNF-α receptor expression augmented in the db/db murine heart, in comparison with …
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The Impact of IL-9 on Disease in Murine Models of Systemic Lupus Erythematosus
… controls. In other antibody mediated autoimmune models, such as rheumatoid arthritis, type II innate lymphoid cells (ILC2s) secrete increased IL-9 to promote the suppressive response of regulatory T (Treg) cells. As such, the role of IL-9 may be context-dependent and requires further …
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Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
… act as oncogenes in cell culture and in animal models. However, the physiological substrate and mechanisms of the PRLs are not yet known. Recently, our lab has developed a PRL 2 knockout mouse and found several striking phenotypes all of which correspond to a significant increase in PTEN. We …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… skin sensitisation during AD. We investigated 3 models of AD using House dust mite (HDM), Ovalbumin (OVA) and low-calcemic analog of vitamin D (MC903) on mouse strains lacking IL-4Ra on various B and T cells. We used mb1creIL-4Rα-/lox (mice lacking IL-4Rα on B cells), iLcKCre IL-4Rα-/lox (mice …
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Unraveling The Effects of Aerobic Exercise and Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models
… vasculature and immune infiltrate, using mouse models and single cell techniques, to elucidate the effects of aerobic exercise and ERK5 signaling. We found that aerobic exercise normalizes tumor vasculature and improves chemotherapy efficacy in certain tumor models and that the ERK5 axis …
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Biodistribution and Modes of Action of Multipotent Adult Progenitor Cell therapy in Murine Models of Transplant Rejection
… safety and therapeutic profiles in experimental models and small clinical trials of transplantation and acute GvHD (aGvHD), however, the mechanisms by which MAPC cells mediate these effects is not entirely clear. Thus, the aim of this thesis was to develop our understanding of the modes of action …
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Establishment and Improvement of Preclinical Murine Models of Severe Scrub Typhus to Define Immune Signatures and Pathogenic Mechanisms
… response. While there are many established murine models of scrub typhus, differences in route of infection, host resistance, and clinically unrelated pathologic outcomes diminish the usefulness of model studies. Therefore, there is a great need for the development of small animal models …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
Cancer cells preferentially utilize glycolysis to generate energy even in the presence of sufficient oxygen for oxidative phosphorylation. This shift in energy metabolism, termed the Warburg effect, is responsible for cancer cells’ high metabolic rate. Therapies that inhibit cancer cell energy …
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Determining the Effects and Signaling Properties of β-Blockers in House Dust Mite-Driven Murine Models of Asthma
… the asthma phenotype in ovalbumin-driven murine models of asthma. Furthermore, our studies suggested that chronic treatment with certain β-blockers such as nadolol and ICI 118, 551 was able to attenuate the asthma phenotype in murine models. However, not all β-blockers seemed to work as …
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TL1A Priming Induces a Multi-Cytokine Th9 Cell Phenotype That Promotes Robust Allergic Inflammation in Murine Models of Asthma
… of IL-9 and IL-13 co-expressing cells in murine Th9 cell cultures, inducing a robust multi-cytokine phenotype. Mechanistically, this is linked to histone modifications allowing for increased accessibility at the Il9 and Il13 loci. We further show that TL1A alters the transcription factor …
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The Effects Of The Estrus Cycle On Microbiota Composition And The Opportunistic Pathogen Listeria Monocytogenes Infection Process In Murine Models
<p>In the U.S., Listeria monocytogenes accounts for less than one percent of foodborne illnesses but has a 28% mortality rate. Infection in healthy individuals causes colonization of the intestinal lumen and subclinical noninvasive listeriosis. However, translocation of L. monocytogenes across the …
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The Development and Assessment of Immune Responses in Plasmid DNA, VSV-Vectored, and Virus-Like Particle HIV Vaccinations in Murine Models
Our previous macaque immunization study demonstrated that vaccinations with the Vesicular Stomatitis Virus (VSV)-vectored HIV vaccine (VSVXN2∆G/CDO-EBOVGP+HIV-1 Codon-optimized A74_Env-EC/SIV_Env-TMCT) in Rhesus macaques provided protection to 50% of the animals against low-dose challenges with …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… by implanting a small number of metastatic murine mammary tumor cells into the marrow cavity of tibia. Subsequent lung metastasis was evaluated. Previously our group reported that estrogens and phytoestrogens stimulated BC primary tumor growth in mice. Estradiol stimulated ER negative BC …
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Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni
Keratinocytes represent the major cell type in the skin. During cutaneous leishmaniasis (CL) and schistosomiasis, the skin is important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 …
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Battling Bacteria: Characterizing the NOD-Like Receptor (NLR) Immune Response to <i>Brucella abortus</i> and <i>Borrelia burgdorferi</i> in Host-pathogen Interactions
… dairy products from livestock. Using murine models and bone marrow-derived macrophages (BMDMs) challenged with Brucella abortus, we found that canonical inflammasomes in murine models were protective against brucellosis through the initiation of inflammatory cell death called …
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