Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"mural cell"”.
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Mesothelial and Mural Cell Contribution to Vascular Development through PDGF Signaling
… of blood vessels from mesoderm precursor cells. Angiogenesis is the formation of new vessels from existing vessels. Both processes involve hematopoietic, endothelial, and mural cells for the formation of mature, stable vasculature. While hematopoietic and endothelial cell contributions and …
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Role of mural Cx43 in vascular interactions and its regulation by breast tumor cells
On normal blood vessels, vascular mural cells (pericytes and smooth muscle cells) serve to stabilize the vessel and render the endothelium quiescent. Tumor vessels, in contrast, exhibit abnormal association between mural cells and endothelial cells which allows the endothelium to be angiogenic. The …
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The Effects of Angiogenic Growth Factors on Mesenchymal Stem Cell Proliferation and Differentiation to Vascular Cell Fates
<p>Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into several cell lineages, including mural cells, which surround and support blood vessels, and possibly endothelial cells, which form the blood vessel walls. In this study, we investigated the effects of basic …
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Investigations into the stability of growth factor induced-vasculature and the effects of synthetic biomaterials on heart remodelling after myocardial infarction
… allows for characterization of stability and mural cell investment of newly created vessels was designed.
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Nkx3.2 regulates zebrafish vascular stabilization through recruitment of mural cells
… development where the immature endothelial cell tube gains structural support through the recruitment and adhesion of perivascular mural cells; pericytes and vascular smooth muscle cells (vSMC). When vessels are not well supported by mural cells hemorrhage can occur. Nkx3.2 deficient …
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Silencing Endothelial EphA4 Alters Transcriptional Regulation of Angiogenic Factors to Promote Vessel Recovery Following TBI
… colocalization and proximity of endothelial and mural cell markers (i.e. PECAM-1 and PDGFRβ, respectively) in immunohistochemically-stained brain sections demonstrates that EphA4 silencing does not seem to affect the physical association between, nor total amounts of, endothelial cells and …
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Genetic Analysis of Adipose Lineage and Development
… the identity of adipocyte progenitor cells and their anatomical niche. Adipose tissues form throughout the body in various places in a stereotypical pattern, with each adipose depot displaying distinctive properties. As the first step to understand depot specificity, I used the …
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Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice
… were surrounded by reactive astrocytes, lacked mural cell coverage and endothelial VEGF expression, and regressed after 21 days of hypoxia. The lack of PlGF, in combination with reduced VEGF expression levels observed in the brain of PlGF-/- animals during the first 5 days of hypoxia, is likely …
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Spatiotemporal Dynamics of Tissue Oxygenation in Awake, Behaving Mice
… which optimizes oxygen supply to respiring cells (‘functional hyperemia’). Recent studies of functional hyperemia in awake rodents shows a bimodal arteriole diameter increase when neural activity is prolonged, indicating at least two primary control mechanisms for an early and late phase. …
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In vitro study of cancer cell extravasation in microfluidic platform
Cancer metastases arise from the cancer cells that disseminate from the primary tumor, intravasate into the vascular system and eventually transmigrate across the endothelium into to a secondary site through a process of extravasation. Microfluidic systems have a major advantage in studying cancer …