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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"multivesicular body"”.
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Mechanisms of Multivesicular Body Biogenesis and Exosome Release
Exosomen sind kleine Vesikel mit einem Durchmesser von ca. 50-100 nm, die von vielen Zellarten sezerniert werden und verschiedene interzelluläre Signalprozesse koordinieren. Nach der Fusion von multivesikulären Endosomen (MVE) mit der Plasmamembran werden die intraluminalen Vesikel (ILV) als …
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Role And Regulation Of ESCRT-III In Multivesiculr Body Biogenesis
… for transports: ESCRT) machinery responsible for multivesicular body: MVB) biogenesis is essential for receptor downregulation, viral budding and cytokinesis. ESCRT-III is a large polymer built from related ESCRT-III proteins that is thought to help generate intralumenal vesicles: ILVs) within the …
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Molecular Mechanisms of Inward and Outward Budding From Multivesicular Endosomes
… at the limiting membrane of the late endosome/multivesicular body (MVB) is dictated by whether they remain on the limiting membrane, bud into internal MVB vesicles, or bud outwardly from the membrane. The molecular details underlying the disposition of membrane proteins that transit this …
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Using human induced pluripotent stem cells to model cystinosis
… of cystine within lysosomes in most cells of the body, however the kidney is the main organ affected. For poorly understood reasons, renal proximal tubule (PT) cells lose their functionality and degenerate in cystinosis, forming a characteristic “swanneck” lesion that leads to kidney failure …
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Structure and Application of Photosensitive Self-assembled Pseudoisocyanine J-aggregates on Membrane Surfaces
… domains during endosomal maturation, leading to multivesicular body formation. These data demonstrate that a correlated optical and topographical approach is necessary to understand the structure of fluorescent molecular assemblies, and form the basis for utilizing such aggregates in a biological …
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Ultrastructural analysis of HIV-1 infection in human cells
… multivesikulären endosomalen Kompartiments (multivesicular body, MVB) als auch bei der Bildung dieser Vesikel eine Rolle. ESCRT fand sich im gesamten endosomalen System einschliesslich der Plasmamembran, und war besonders an tubulär-vesikulären endosomalen Membranen, aber nicht an MVBs, …
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The mode of action of Epicoccum derived antimicrobials
… of the membrane protein endocytosis and multivesicular body (MVB) sorting pathways, and β-oxidation of fatty acids. To our knowledge, this was the first time to report a polyene class of antifungal compound directly affecting sphingolipids – possibly not ergosterol, which is a well-known …
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Analysis of the maturation of Rhodococcus equi-containing vacuoles in macrophages
… which has left vacuoles that resemble multivesicular body compartments (MVB), which are transport intermediates between early and late endosomes and display internal vesicles very similar to the ones observed within RCVs. Analyisis of several R.equi strains containing either VapA- or …
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Using Chemical Probes to Examine Cellular Activities
… accumulation of the ESCRT-III protein, charged multivesicular body protein 4B (CHMP4B). Together, these data suggest that spastin dynamics during late anaphase are decoupled from ESCRT dynamics and are instead modulated by the presence of microtubules and spastin's ATPase activity. In the second …
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Regulation of The Escrt Function of Alix
… ESCRT-mediated processes, including MVB (multivesicular body) sorting, cytokinetic abscission and retroviral budding. Previous studies have demonstrated that ALIX involvement in these ESCRT-mediated processes requires ALIX interaction with the ESCRT-III component CHMP4 as well as a cargo …
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Characterization of The Ubiquitin Ligase, Ube4B, In Endocytic Trafficking
… into vesicles that bud into the lumen of the multivesicular body (MVB). Inclusion into internal MVB vesicles designates EGFR for lysosomal proteolysis and extinguishes their signaling activity.</p> <p>Ubiquitination is a post-translational modification that underlies some aspects of membrane …
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The Ubiquitin Ligase Ube4B Is Required For Efficient Epidermal Growth Factor Receptor Degradation
… early endosomes, and subsequently late endosomes/multivesicular bodies (MVBs), before being degraded in the lysosome. The MVB is a subset of late endosomes characterized by the appearance of small vesicles in its luminal compartment. These vesicles contain cargo proteins sorted from the limiting …