Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"multivalent vaccine"”.
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Development of a flagellin-based multivalent vaccine against Pseudomonas aeruginosa
… fibrosis (CF) patients, there is no approved vaccine for human use against P. aeruginosa. The goal of my research was to establish whether a multivalent vaccine containing P. aeruginosa type A and B flagellins as well as the outer membrane proteins OprF and OprI would promote enhanced …
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Development of a broadly protective protein-based multivalent vaccine against cholera and beyond
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Elucidating the Immunogenicity and Protective Immune Response of a Trivalent Vaccine for Sudan Ebola, Marburg, and Lassa Fever Viruses
… access to healthcare, the development of a multivalent vaccine candidate with the aim of eliciting protection against all three viruses presents a preferred approach. However, administering multiple antigens simultaneously may lead to antigenic competition, potentially diminishing the …
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Development of a Subunit Vaccine Against Bovine Diarrhea Caused by K99 Enterotoxigenic Escherichia coli and Bovine Viral Diarrhea Virus
… and other illness to cattle at all ages. A vaccine that prevents against both K99 fimbrial ETEC and BVDV could benefit greatly to cattle producers worldwide. We hypothesized that a novel multivalent vaccine composed of K99, STa and BVDV E2 antigens could induce immunity for broad protection …
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Molecular modeling of bacterial polysaccharide antigens to inform future vaccine development
Polysaccharide conjugate vaccines have been pivotal in reducing the prevalence and severity of bacterial infectious diseases worldwide, preventing countless deaths. The effectiveness of a vaccine can be extended if the selected vaccine strains in a multivalent vaccine cross-protect against …
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Assessing TMV as an immunogenic particle : the expression of HIV-1 subtype C V3 loop neutralizing antibody epitopes on the surface of TMV virions
… subtype C neutralizing antibody stimulating vaccine, a Tobacco mosaic virus (TMV) derived vector was used to express recognized HIV neutralizing antibody epitopes. These epitopes were expressed on the surface of the TMV coat protein, which served as an ideal means of antigen display. This …
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The Immunogenicity of Plant-produced Human Papillomavirus (HPV) Virus-like particles (VLPs) in Mice
… the foundation on which commercially available vaccines have been developed. There are 3 commercially available HPV vaccines that are effective at preventing HPV infections, but are expensive, therefore limiting their use in the poorer developing countries where they are most needed. Thus, there …
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Development of plant-produced African horse sickness vaccines
… warming and climate change. Live attenuated vaccines (LAV) have been used with relative success for many decades, but carry the risk of reversion to virulence and/or genetic re-assortment between outbreak and vaccine strains. Furthermore, the vaccines lack DIVA capacity, the ability to …
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Development of an Antibiotic Resistance Free Bivalent Vaccine Against Swine Brucellosis and Swine Influenza
… disease is not endemic. At present, there is no vaccine available for swine brucellosis. The currently used swine influenza vaccine may not be effective against influenza strains like the recent H1N1 strain that caused a pandemic. To develop an effective bivalent vaccine for swine against these …
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Role of Staphylococcus aureus GapC and GapB in immunity and pathogenesis of bovine mastitis
… than strengthening local intramammary immunity. Vaccines aimed at enhancing intramammary immunity of dairy cows against S. aureus mastitis have had limited success. Commercially available vaccines show various degrees of success and work in research laboratories with experimental vaccines suggest …
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Development and characterization of Shigella multiepitope fusion antigen (MEFA) for a broadly protective subunit vaccine against shigellosis with extended utility against enterotoxigenic Escherichia coli.
… and with increasing multidrug resistance. Vaccines represent a significant preventive measure against infectious diseases; however, no approved vaccines are currently available to protect against Shigella spp. A critical challenge in developing vaccines for Shigella lies in achieving …