Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"multivalent display"”.
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Development of bispecific filamentous bacteriophages for the generation of a novel automated screening system based on phage display technology
Phage display is a powerful tool for screening large protein libraries in order to identify novel therapeutics, diagnostics or vaccines. In the emerging field of protein based drug development, there is an urgent need for high-throughput technologies for automated library handling and phage display …
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Lipid-coated micro- and nanoparticles as a biomimetic vaccine delivery platform
… provide a unique opportunity to control the display, release, and in vivo trafficking of vaccine components. We have designed and characterized a system for vaccine delivery that uses a "lipid surfactants" approach to combine a degradable polymer core with a two-dimensionally fluid lipid …
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Recombinant Mucins with Tailored Glycosylation as Bacterial Toxin Inhibitors
Multivalent carbohydrate-based ligands that can inhibit biomedically important protein–carbohydrate interactions have therapeutic potential. One of the important targets for therapeutic intervention is the binding processes mediated through the interactions of bacterial toxins with cell-surface …
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Exploring multivalent technologies and strategies for directed protein evolution
… during the selection process, a new in vitro multivalent selection system was developed, that allowed for the display of proteins of interest under defined valencies. Using this system, different valency effects could be quantified and mapped. The observations of vastly improved recoveries and …
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Understanding Elastin-Like Polypeptide Block Copolymer Self-assembly Behavior
… ELP diblocks offer a unique method to display targeting proteins multivalently on micelles to improve tumor cell uptake. As ELPs are genetically encoded, proteins can be seamlessly fused at the genetic level to the ELP diblock. The protein ELP diblock fusions can be synthesized as one …