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Leveraging Local Perturbations to Map Allosteric Networks of Phosphatases

Mehlman, Tamar (Skaist)The Graduate School and University Center of The City University of New York2023

… fragment soaking and room-temperature X-ray crystallography to determine how temperature affects the occupancy, pose, and location of small-molecule fragments binding to PTP1B. These structures also indicated that temperature can modulate protein conformational responses to ligand …

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