Global ETD Search
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Showing 1 to 4 of 4 for “"multistate design"”.
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Methods and Applications of Computational Design in Multiple States
… Over the past two decades, our ability to design proteins has advanced significantly, however, our understanding of and ability to design multistate proteins remains an area of significant challenge. The multistate design challenge hinders our ability to engineer functional proteins like …
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Multistate analysis and design : case studies in aerospace design and long endurance systems
… an integrated process for the early-stage, multistate design of aerospace systems. The process takes into early consideration the many partially degraded states that real-world systems experience throughout their operation. Despite advancing efforts aimed at maintaining operation in a state …
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Multistate Computational Protein Design: Theories, Methods, and Applications
Traditional computational protein design (CPD) calculations model sequence perturbations and evaluate their stabilities using a single fixed protein backbone template in an approach referred to as single‐state design (SSD). However, certain design objectives require the explicit consideration of …
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Computational design of orthogonal antiparallel homodimeric coiled coils
… interactions simultaneously. The results of the design process can also have interesting applications in synthetic biology or bionanotechnology. The coiled coil, a rope-like structure made of helices, is a PPI ubiquitously found in biological systems and is an attractive fold for engineering …