Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"multipotent progenitor"”.
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
… can be generated from the oligodendrocyte progenitor cell (OPC), a multipotent progenitor cell of the central nervous system. However, the efficiency of this regenerative process declines with ageing, leading to neurodegeneration and progressive neurological dysfunction in older individuals …
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Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration
… decrease in the osteoblastic differentiation of multipotent progenitor cells found in the bone marrow. In order to determine if there is a change in the osteogenic potential of the bone marrow stroma following glucocorticoid treatment, Sprague-Dawley rats were administered methylprednisolone for …
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Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis
… for the survival and proliferation of committed progenitor cells and development of different blood cell lineages. However, their potential role in regulating HSCs remains to a large degree unresolved. Herein, we provide data that establish the adaptor protein LNK as an important negative …
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
… expression signatures of in vivo foetal lung multipotent progenitor cells which are capable of giving rise to all epithelial lineages. The extrinsic factors that regulate human lung progenitor cell self-renewal and differentiation are extensively studied by manipulating the culture conditions. …
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Functional and Transcriptional Heterogeneity of the Human Haematopoietic Stem Cell Pool at Steady-State and Under Inflammation
… by a functionally heterogeneous pool of multipotent haematopoietic stem cells (HSCs), downstream of which lineage-restricted progenitors are generated. The advent of single cell technologies has changed our view of the haematopoiesis to a dynamic continuum. Understanding the early …
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The Characterization of Hematopoiesis in Murine Fetal Bone Marrow
… stem cells (HSCs) and their downstream progenitors are a heterogeneous population of cells that are indispensable for lifelong hematopoiesis and are often utilized in the clinic for the treatment of hematologic maladies via hematopoietic stem cell transplantation (HSCT). Over several …
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Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
… and self-renewal in haematopoietic stem and progenitor cells. Leukaemogenic mutations commonly disrupt these regulatory programs causing a block in differentiation with simultaneous enhancement of proliferation. AML is a genetically heterogeneous disease characterized by chromosomal …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
During tissues development multipotent progenitor cells establish tissue-specific gene expression programmes, leading to differentiation into specialized cell types. It has been previously shown that the transcription factor p63, a master regulator of skin development, controls the expression of …
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Cell Fate Decisions in the Developing Lung
… et al., 2020). Research has suggested that a multipotent progenitor population of epithelial cells resides in the distal tip of the developing lung (Nikolić and Rawlins, 2017) and is capable of differentiating into both bronchiolar and alveolar cells. Clarifying which tip cells differentiate …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… epithelium is composed of multiple cell types. Multipotent, progenitor basal cells are transit-amplifying cells that reside along the basal lamina of the airway which differentiate into surface cells. Basal cells are instrumental in the maintenance of normal epithelial structure and function as …
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Development of single-cell Raman spectroscopy for noninvasively screening the differentiation of living stem and progenitor cells in biomaterial platforms for 2D and 3D cell culture
Stem and progenitor cells' capabilities to self-renew, differentiate, and proliferate within their native tissue made them the subject of ongoing studies to understand the mechanisms of such processes and their potential use as therapeutics. Regenerative medicine encompasses the idea of treating …
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Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy
… therapeutical potential of the lymphoid primed multipotent progenitors (LMPPs) for immune reconstitution in a model of fetal X-SCID transplantation. We find that LMPPs generate rapid and sustained lymphoid reconstitution with polyclonal T cells, but that HSCs are most likely required for long …