Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"multiplex detection"”.
-
Surface enhanced Raman scattering based assays for DNA detection by
… (SERS) based molecular diagnostic assays for the detection of specific DNA sequences have been developed in recent years to compete with the more common fluorescence based approaches. Current SERS assays require either time consuming separation steps that increase assay cost and can also increase …
-
Silicon photonic microring resonators for the development of cancer protein biomarker assays
… needed for a personalized medical diagnosis. Multiplexed biomarker panels have the potential to overcome the limitations of single biomarker analysis due to the greater information content present in a panel of biomarkers, but technologies to rapidly, accurately, and reproducibly make …
-
Forensic applications of raman spectroscopy
… of achieving molecularly-specific and sensitive detection of TNT vapour using waveguide-enhanced, surface-enhanced resonance Raman spectroscopy was investigated using reference spectra measured using a calibrated optical system provided by a collaborator. Improvements in signal-to-noise ratio …
-
Preparation and evaluation of polymer microspheres for enhanced lateral flow immunoassay: the case study for malaria
… termed ReSyn, could be developed as viable detection reagents for lateral flow technology. This body of work outlines the development of this new high capacity polymer microsphere technology for suitability to flow on lateral flow membranes, and highly specific biomarker detection for …
-
Development of surface-enhanced Raman spectroscopy coupled with nanosubstrates and machine learning to improve food safety
… hazardous residues in fresh produce. Traditional detection methods, such as chromatography, though accurate, are time-consuming, expensive, and require complex sample preparation. This dissertation introduces a novel and efficient approach for the rapid, non-destructive, and multiplex detection of …
-
Molecular imaging with mass spectrometry: instrumental and methodological advances for biological applications
… label-free, non-targeted, and highly multiplex detection and imaging of chemical species ranging in mass from single protons to large proteins exceeding 100 kDa, identifiable by mass and confirmed (when possible) by structural information obtained through tandem MS experiments. These …
-
Multifunctional nanoparticle-coupled photonic resonator for rapid and digital biosensing
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
-
Development of a High Sensitivity, Multiplex Vertical Flow Immunoassay System for the Detection of Biothreat Agents
… decentralized systems that enable early detection and expedite appropriate countermeasures. However, a critical gap exists between field-deployable systems that are cost-effective and those that offer highly sensitive, multiplex capabilities for biothreat detection. The goal of this …
-
Development of silicon photonic microring resonator biosensors for multiplexed cytokine assays and in vitro diagnostics
… display great potential for more highly multiplexed (100s-1000s) measurements based on the impressive scalability of silicon device fabrication (a 128-ring array chip design is currently under development). Though this technology can be used to detect a variety of molecules, this …