Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"multiple system atrophy"”.
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The Application of Mesenchymal Stem Cell therapy on Multiple System Atrophy
Since disease progression in multiple system atrophy(MSA) is much faster and no drug treatment consistently benefits MSA patients in the long-term, neuroprotective or regenerative strategies are inevitable in the management of MSA patients. We divided two group, MSC-treated(n＝11) and control …
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CARDIAC AUTONOMIC CONTROL DURING SLEEP IN PATIENTS WITH MULTIPLE SYSTEM ATROPHY: A PILOT STUDY ON THE IMPACT OF CPAP THERAPY
… characterize sleep-stage autonomic regulation in multiple system atrophy (MSA) using cardiorespiratory coupling (K2) and symbolic dynamics (0V%, 2UV%, 2LV%) derived from ECG tracings in video‐polysomnography (v‐PSG). The study aims to compare patients with and without sleep‐disordered breathing …
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The prion-like properties of assembled human alpha-synuclein
… disease, dementia with Lewy bodies and multiple system atrophy, as well as of rarer diseases, collectively called synucleinopathies. For a long time, it was widely believed that neurodegenerative diseases were cell-autonomous; however, a more recent hypothesis has suggested that some …
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Imaging Correlates of Heterogeneity in the Syndromes Associated with Frontotemporal Lobar Degeneration
… the same clinical presentation can be caused by multiple pathological entities. Heterogeneity makes predicting underlying pathology and longitudinal outcomes challenging in clinical practice and in research settings. I propose that a multi-modal imaging approach, including structural and …
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Investigating the Potential Role of α-Synuclein in Tau Aggregation and Toxicity
… (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), LBs and LNs have been reported in Alzheimer’s disease (AD) patients as well. Both α-Syn and tau can exist as polymorphic aggregates, and this phenomenon has been widely studied, mostly in their fibrillar assemblies. …
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Solid-state NMR structural investigations of alpha-synuclein fibrils derived from Lewy Body dementia brain tissue
… dementia (LBD), Parkinson’s disease (PD), and multiple system atrophy (MSA). Despite this fact, there is currently no way to detect or quantify these fibrils in living patients, which could significantly improve diagnosis and treatment strategies. Knowledge of the atomic structures of the …
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Structural studies of the in vitro assembly of tau and α-synuclein amyloids
… filaments with seeds from brains with Multiple System Atrophy (MSA), and show that seeded assembly does not necessarily replicate the structures of the seeds. The results in this section have important implications when interpreting seeded assembly assays. In the future, it will be …
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Neuroprotective effect of mesenchymal stem cells in neurodegenerative disease : focusing on Parkinsonian disease
… in an animal model of double lesion-induced multiple system atrophy-parkinsonism (MSA-P). PART B. Inhibition of blood brain barrier (BBB) permeability by hMSCs. First, the double lesion-induced MSA-P was established with co-injections of MPTP (10mg/day, total dose 90 mg/kg for 9 days) and 3- …
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Studies on the Cytoplasmic Inclusions Detected in Parkinson's disease
… (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Synphilin-1, interaction partner of α-Synuclein is a major component of inclusion bodies, but it is unknown how synphiln-1 contributes to the cellular and biochemical mechanisms of PD, and its normal functions and …
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Progression and variation of Progressive Supranuclear Palsy
… Supranuclear Palsy-Corticobasal Syndrome-Multiple system atrophy study” (PROSPECT-M-UK). Finally, I identify structural correlates of survival. After an introduction to the issues and principal research questions (Chapter 1) and general methods (Chapter 2), I exploit the prospective UK …