Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"multiple organ failure"”.
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… to infection that can lead to life-threatening multiple organ failure. Due to the unacceptably high mortality and the lack of effective pharmacological intervention, there is an unmet clinical need to develop novel therapeutic approaches to treat sepsis. Endothelial dysfunction is a hallmark of …
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Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23
… may play a role in the development of sepsis and multiple organ failure reported in burn and trauma patients. In line with this hypothesis, our laboratory has demonstrated increased intestinal tissue damage, leakiness and bacterial translocation as well as intestinal T lymphocyte suppression …
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Multi-Cellular Organotypic Liver Models for the Investigation of Chemical Toxicity and Liver Fibrosis
… and the stratified microarchitecture of the organ. In vitro liver models provide insights into the role of each cell type and perturbations upon external stimuli. Despite the dissimilarities to in vivo and rapid dedifferentiation, most liver studies utilize hepatocyte monocultures. These …
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Identification of novel coding single nucleotide polymorphisms associated with acute respiratory distress syndrome
… mediators, causing inflammation, hypoxemia and multiple organ failure. Disease susceptibility and progression are poorly understood and there are few effective therapeutic options. Existing biomarkers have limited effectiveness as diagnostic and therapeutic targets. Whole-exome sequencing is an …
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Investigation of splanchnic perfusion utilising an intraluminal opto-electronic sensor placed in the duodenum
The splanchnic region (abdominal gastrointestinal organs) is sometimes known as the “canary of the body” for its susceptibility to develop hypoxia at an earlier stage, analogue to the old times practice in coal mining. When the neuroendocrine response is activated, it exhibits regulation of blood …
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A Mathematical-Experimental Strategy to Decode the Complex Molecular Basis for Neutrophil Migratory Decision-Making
… homeostasis. However, neutrophils are exposed to multiple chemoattractants and must prioritize these signals in order to correctly migrate to the appropriate site. The ability of neutrophils to properly undergo chemotaxis in the presence of infection and inflammation is crucial for resolution of …
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A study of potential serum markers for a diagnosis of gram-positive and gram-negative bacterial sepsis
… can readily lead tosevere sepsis, septic shock, multiple organ failure and death. The onset can be rapid and difficult to define clinically. Despite the numerous candidate markers proposed in the literature, to date a serum marker for sepsis has not been found. The aim of this study was to assay …
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Interleukin-6 and Interleukin-10 concentrations as predictors of patient outcome following major traumatic injury
… from thecomplications including sepsis and multiple organ failure, occurs in the days and weeksfollowing the initial traumatic insult. These complications develop due to an imbalance between the pro-inflammatory and antiinflammatoryresponse to traumatic injury. This imbalance results in the …
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Major traumatic injury : serum cytokine biomarkers as predictors of poor clinical outcome
… by further complications such as sepsis, multiple organ dysfunction and multiple organ failure. This is caused by an imbalance between pro-inflammatory and anti-inflammatory responses to traumatic injury, largely orchestrated by cytokines.Cytokines are known, to be predominantly secreted …
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Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells
… infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. An impaired immunologic response, including dysfunctional peripheral blood immune cells has been described as part of the septic syndrome. …
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Effects of Ubiquinol with Fluid Resuscitation following Hemorrhagic Shock
… intrinsic pathway of apoptosis and contribute to organ dysfunction.1 Ubiquinol is a potent free radical scavenger which is produced endogenously and functions as part of the mitochondrial respiratory chain.2 No study has been conducted to investigate the effects of ubiquinol related to HS. The …
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Investigating cytokine biomarkers as early predictors of poor clinical outcome following major trauma
… days post-trauma) areattributed to progressive multiple organ failure (MOF) and sepsis postulated to result fromdysfunctions of the immune system. Depending on the severity of trauma, the immuneresponse can be over-active with uncontrolled release of pro and anti-inflammatorymediators causing …
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Änderungen der intestinalen Permeabilität mit systemischer Zytokinaktivierung nach grossen Operationen bei der Entstehung des Multiorganversagens
… beobachtet, die als wichtige Ursache des Multiorgandysfunktionssyndroms (MODS) angesehen wird. Der Pathomechanismus dieses frühpostoperativen SIRS ist nicht bekannt. Bei der "Darm-Sepsis-Hypothese" geht man davon aus, dass der Zusammenbruch der intestinalen Barriere mit bakterieller …
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Rendimiento diagnóstico de los criterios de Atlanta para clasificar severidad en pancreatitis aguda, en pacientes del hospital universitario mayor
La severidad en la pancreatitis aguda actualmente se hace con los criterios de Atlanta, la cual se establece según la presencia de falla orgánica en el paciente; sin embargo se considera que en Bogotá esta severidad al ingreso no se correlaciona con la evolución clínica de los pacientes por la …