Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"multiome"”.
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Bioinformatic Approaches to Study Mitochondrial DNA Heteroplasmy
… the main challenges of working with single-cell multiome data, with a focus on mitochondrial genomics. A key objective in the field is to estimate hetero plasmy at the single-cell level. The ATAC library of multiome experiments yields a large number of mitochondrial reads; however, determining …
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The Role of the Transcription Factor CEBPA in Regulating Lung Alveolar Type 2 Cell Fate In Vivo
… the gene regulation of Cebpa through single-cell multiome analyses and CRISPR genome engineering uncovers the essential role of distal regulatory elements (REs) in the epithelial expression of Cebpa in mouse lungs. Integrated analysis of single-cell multiome as well as bulk cell-type-specific …
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Genetic analysis of Kmt2d loss in tumorigenesis using genetically engineered mouse models
… into squamous carcinoma. Single cell multiome analysis revealed that squamous carcinoma evolved from a highly plastic cluster, which expresses both lung and gastric markers. It is inferred that squamous carcinoma evolved from adenocarcinoma because of the inability to maintain …
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Resolving developmental dynamics using single-cell sequencing data
How an organism grows and develops is one of the fundamental questions in biology. A deeper understanding of developmental programmes can help to answer those questions and also generate new insights into disease and potential treatments thereof – pathways active during development often reappear …
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Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
Biomedical research relies heavily on the use of model organisms to gain insight into human health and development. Traditionally, the mouse has been the favoured vertebrate model, due to its experimental and genetic tractability. Non-rodent embryological studies however highlight that many aspects …