Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"multigenic"”.
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Multigenic Regulation of the Shutdown of Immune Responses
The goal of the work presented here was to determine if blocking cell death could affect the shutdown of immune responses by generating increased numbers of antigen-specific memory CD8+ T cells. During acute viral infection, large numbers of effector CD8+ T cells are generated. Following viral …
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Monogenic, multigenic, and polygenic determinants of cancer risk
… a series of genetic possibilities: monogenic, multigenic, and polygenic, are provided. It is expected that technology will be developed to identify and enumerate rare inherited alleles in large general and cancer proband populations.
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Characterization of Candidate Mutations for Use in a Live Attenuated West Nile Virus Vaccine
… (E), NS4B, and NS5 proteins. Additionally, multigenic mutants were investigated that combined mutations in the NS1 protein with mutations in the E or NS4B proteins, as a vaccine with multigenic mutations should have fewer chances of reversion to virulence. The E mutation investigated, E138K, …
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Inherited risk for common disease
… formulae that describe the risk for monogenic, multigenic, and polygenic possibilities of Mendelian inheritance. Next, we obtained an estimate of minimum lifetime risk for CRC of >0.26. Then, we examined the case of late-onset CRC, using the Swedish Family Cancer Database (1958-2002) to estimate …
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Gene mutations and expression in breast cancer
… Like all other cancers, breast cancer is a multigenic disorder with mutations in oncogenes and tumour suppressor genes playing an important role in cellular transformation and ultimately in tumour formation. In this study, 40 breast cancer patients from the Western Cape province in South …
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Genetic, biochemical, and molecular studies of the Bowman-Birk inhibitors in the genus Glycine Willd
… inhibitor activity) inherited as a quantitative/multigenic trait with 18-34% of the F$\sb2$ progeny exceeding the high parent (cv. Kunitz) in their activity suggesting a transgressive nature of inheritance. A ""new"" electrophoretic band with trypsin and chymotrypsin inhibitor activities …
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Interactions Between Herbicides and Soybean Diseases
… and F3 generations indicate that resistance is a multigenic trait.
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Using the Cre-loxP system to randomize target gene expression states and generate diverse phenotypes
… of their function and the engineering of complex multigenic cellular phenotypes. However, deletion or overexpression of multiple genes is typically laborious and involves multiple sequential genetic modifications. Here we describe a strategy to randomize the expression state of multiple genes in …
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The rhinoceros gene of drosophila restricts cell fate specification in the developing eye
… that the defining phenotype of EY3-5 is a multigenic effect caused by large deletions present in the two founding alleles of EY3-5. These studies led to the investigation of the roles of three genes in signal transduction. The strongest enhancer of YanACT among these three genes, called …
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Molecular implications of prolonged DDT selection in Drosophila melanogaster
… response to DDT in 91-R and 91-C, I identified a multigenic adaptive response to DDT in 91-R along with multiple roles for gene regulatory cascades around stress responses, cell survival, and neurological function. Furthermore, both the genotypic and phenotypic diversity of the phase I …
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Harnessing mutagenic homologous recombination for in vivo targeted mutagenesis by TaGTEAM
… to evolutionary engineering approaches for multigenic phenotypes is the ability to simultaneously modify multiple genes rapidly and selectively. Here, we describe a method for in vivo targeted mutagenesis in yeast, TArgeting Glycosylases To Embedded Arrays for Mutagenesis (TaGTEAM). By …
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Applications of genome editing for disease modeling in mice
… which opens up the possibility of interrogating multigenic biological processes. In this thesis, we utilize the Cas9 technology to facilitate genome editing experiments in vivo in mice. First, we create a Cas9 knockin mouse and demonstrate its utility for in vivo and ex vivo genome editing …
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Mapping the Landscape of Acquired Vulnerabilities in Ovarian Cancer
… a chaotic genetic background. miRNAs function as multigenic perturbations allowing for interrogation of maximal gene space with few experiments. This screen identified multiple miRNAs reducing cell viability with the majority of hits being toxic in only one or two lines screened. This surprising …
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In Vivo Genome-Wide Analyses of the Drosophila p53 Transcriptional Network
… multiple targets simultaneously; however these multigenic complexes appear in low frequency. I also have preliminary genome-wide data suggesting in embryos this p53 enhancer contacts additional p53 targets. In addition, through genome-scale analyses I dissected novel p53 programs in a …
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The role of genetic alterations in the gut-joint axis of Crohn's disease and Spondyloarthropathies
… extraintestinal manifestations. In view of the multigenic character of CD and SpA, presumably several genes play a role in the disturbed handling of bacterial flora and the possible circulation of antigens between intestine and joint. Further research in both disease entities is mandatory to …
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Molecular epidemiology of West Nile virus in North America
… in WNV that provide valuable insight into the multigenic components of pathogenicity for WNV and possibly other related flaviviruses.
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The physiology, mapping, and prediction of stable carbon isotopes: a proxy trait for water-use efficiency in maize
… did not. Our results show the complexity and multigenic nature of δ13C, thus highlighting the need for approaches that combine effects from every marker. Genomic prediction is one such method to account for the additive nature of this phenotype. The integration of physiological and genetic …
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The Mycobacterium smegmatis "Proteome" : effects of growth phase on total protein synthesis and on the response to heat shock
… proteins should enable their roles in the multigenic processes that occur during transition into stationary phase to be determined. The amino acid sequence of one of the - 17 kDa heat shock proteins (with an apparent molecular weight of 16.8 kDa, named Hspl7-2) showed significant homology …
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Algorithms for regulatory network inference and experiment planning in systems biology
… that can be used to validate predictions of multigenic perturbations made by mathematical models. (i) I present CrossPlan, a novel methodology for systematically planning genetic crosses to make a set of target mutants from a set of source mutants. CrossPlan is based on a generic experimental …
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Genetic Analysis of Drosophila Stomatogastric Nervous System
… syndrome of colon and rectum (HSCR) is a multigenic congenital disease and occurs one in five thousand live births (0.02%). Affected children require corrective surgery due to a lack of neurons in the lower intestine. The main causative mutations for HSCR are in the Ret receptor tyrosine …
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