Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"multifactorial diseases"”.
-
Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases
… limitation in the case of multi-factorial diseases (e.g. neurodegenerative disorders) is that effective therapy may require multi-target drugs addressing the complexity of multi-factorial pathologies. Here, single- and multi-target ligand design was investigated to discover novel compounds …
-
Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
Psychiatric disorders are complex, multifactorial diseases characterized by disruption of neural circuits, accompanied by an imbalance of excitatory and inhibitory inputs leading to dysregulations in neuronal excitability. Recent research focused on uncovering novel causes of psychiatric disorders …
-
Identification of Differentially Expressed Gene Modules in Heterogeneous Diseases
… associations between biomolecules and human diseases. This is a great advance for science and medicine since it helps to unravel the mechanisms of the diseases and gives clues for new treatment approaches. At the same time, a tremendous amount of raw experimental data and biomedical knowledge …
-
New Synthetic Polyamines as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease and Cancer: Design, Synthesis and Biological Evaluation
… main causes of death worldwide. They are complex multifactorial diseases and several biochemical targets have been recognized to play a fundamental role in their development. Basing on their complex nature, a promising therapeutical approach could be represented by the so-called …
-
A linkage study of autism using multipoint sib-pair analysis
… statistical approaches to the analysis of multifactorial diseases, the molecular characterisation of genes that have a small effect on the overall aetiology of complex polygenic disorders, such as autism, could soon be feasible.
-
FUNCTIONAL FEED ADDITIVES FOR ANIMAL HEALTH
… sources that predispose young animals to develop multifactorial diseases, particularly from gastrointestinal origin, that causes important economic losses and antibiotic use. Nutrition is no longer considered as science that only satisfies nutritional requirements but is considered fundamental for …
-
Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
Inflammatory bowel diseases (IBD) are chronic diseases of the gut affecting a significant proportion of the population in the western world with increasing incidence globally. They are multifactorial diseases with susceptibility mediated by a combination of host genetics and environmental factors …