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Showing 1 to 10 of 10 for “"multidrug resistance proteins"”.
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Modulation of the Expression of Multidrug Resistance Proteins by Sulforaphane and Erucin
Sulforaphane increases gene expression through binding of the Nrf2 transcription factor to the antioxidant response element (ARE) in the promoter region of target genes. Because SF and ER increased MRP1 expression at the mRNA level, we investigated the impact of these compounds on MRP1 …
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Characterization and Inhibition of the Dimer Interface in Bacterial Small Multidrug Resistance Proteins
As one of the mechanisms of antibiotic resistance, bacteria use several families of membrane-embedded α-helical transporters to remove cytotoxic molecules from the cell. The small multidrug resistance protein family (SMR) is one such group of drug transporters that because of their relative small …
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Multidrug resistance proteins (MRP) transport the cytokine/nuclear protein High Mobility Group Box 1 (HMGB1) across membranes
… usually present at the Nterminus of secreted proteins that is sufficient to address them through the ER/Golgi exocytic pathway. This work focused on the molecular mechanism by which HMGB1, as a leaderless protein, can be actively exocytosed by living cells. HMGB1 undergoes post-translational …
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Kinetics and mechanisms of accumulation for liposomal ciprofloxacin into rat alveolar macrophages
… and involve probenecid-sensitive multidrug resistance proteins (MRPs). Overall, Lipo-CPFX enabled greater drug accumulation into the NR8383 cells than CPFX. This logically suggests a greater potential to treat respiratory infections especially caused by bacteria resistant to …
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Expression of the P-glycoprotein Homologue1 on food vacuoles isolated from Chloroquine-sensitive and resistant Plasmodium falciparum strains
Worldwide occurrence of chloroquine resistance is an expanding problem in prophylaxis and treatment of malaria. Similarities between the drug resistance phenotype in certain cancers and in malaria suggest that homologue multidrug resistance proteins might be involved in the mechanism of resistance. …
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Einfluss der löslichen Guanylylzyklase auf die Expression der cGMP-Exporter MRP4 und 5 in humanen Melanomzellen unter Hypergravitationsbedingungen
… highly-selective nucleotide transporters MRP (multidrug resistance proteins) 4/5 in human melanocytes and melanoma cells with different metastatic behaviour. Based on these results the influence of the soluble, NO-sensitive guanylylcyclase (sGC) on the hypergravity-induced expression of MRP4/5, …
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Differente Expression der Multidrug-Resistenz-Proteine 4/5 in nicht und stark metastasierenden Melanomzellen unter Hypergravitationsbedingungen
Multidrug resistance proteins (MRPs) are transmembrane proteins with the potential to export a wide range of substances in the extracellular space preventing cells from toxification. MRP4 and 5, on which this investigation is focused, particularly mediate nucleoside-analogue export, i.e. guanosine …
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EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
… viral replication and may lead to viral resistance. Sub-therapeutic concentration of PIs in brain leads to drug resistance and HIV associated dementia. One of the major factors which limit central nervous system (CNS) permeation of PIs is the presence of efflux proteins on brain capillary …
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Evaluation of Novel Efflux Transport Inhibitor for the improvement of drug delivery through epithelial cell monolayer
… within the cells. Efflux system consists of multidrug resistance proteins such as P-glycoprotein (P-gp). P-gp removes substances out back from the brain to the blood before they reach to the brain. So the barrier is impermeable to many compounds such as amino acids, ions, small peptides and …
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Hypergravitationsinduzierte Effekte auf cGMP-Konzentration humaner Melanozyten und Melanomzellen
… and of the cGMP transport by the multidrug resistance proteins MRP4 and MRP5. Importantly, expression and stimulation of soluble guanylyl cyclase isoform by a nitric oxide donor and of the membrane isoforms by natriuretic peptides were not changed by hypergravity in comparison to …