Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"multicomponent reactions"”.
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Evaluation of microreactor technology for multicomponent reactions
… naar de toepasbaarheid van deze technologie voor multicomponentreacties. Hierbij werd gebruik gemaakt van een commercieel beschikbaar microreactor systeem. In een eerste luik werd de Baylis-Hillman reactie onderzocht. Deze driecomponentreactie, waarbij hoog gefunctionaliseerde …
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Multicomponent Diels-Alder Sequences of 1-Aminodendralenes
… in situ generated acyclic 1-aminodendralenes in multicomponent diene-transmissive Diels-Alder (DTDA) reaction sequences. Dendralenes have previously been shown to generate polycyclic frameworks in a step-economic manner. The 1-amino substituent is shown to promote very high levels of site …
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Multicomponent Diels-Alder Sequences of 1-Aminodendralenes
… in situ generated acyclic 1-aminodendralenes in multicomponent diene-transmissive Diels-Alder (DTDA) reaction sequences. Dendralenes have previously been shown to generate polycyclic frameworks in a step-economic manner. The 1-amino substituent is shown to promote very high levels of site …
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Understanding the singlet oxygen reactivity of salarin C through synthesis of a simplified macrocyclic analogue; multicomponent, enantioselective organocatalytic synthesis of tetrahydropyridazinones.
… cause of the aerobic rearrangement. Secondly, a multicomponent reaction was developed towards the synthesis of tetrahydropyridazinones. Multicomponent reactions are extremely advantageous methodologies as they allow the formation of complex scaffolds from simple starting materials and have shown …
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Rhodium-catalyzed Asymmetric Carbon-Carbon Bond Formation Leading to the Development of Rhodium/Palladium Multi-metal Catalysis
… palladium catalysis in the development of domino reactions. The contents are divided into 4 chapters. Chapter 1 describes the rhodium-catalyzed asymmetric ring opening (ARO) of strained bicyclic alkenes using silyl enolates. The development of this method achieved a highly enantioselective …
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OPENING NEW CHEMICAL SPACE IN DRUG DISCOVERY
… synthetic approaches, the high potential of the multicomponent reactions with unprecedented components has been exploited and, on the other hand, new protocols have been finely tuned to achieve new transformations. The synthesis of promising bioactive compounds and the creation of chemical …
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Synthesis of Cyclopropane-Fused 1,5-Diazocin-2-ones via Metal-Templated Intramolecular Addition of Nitrogen Nucleophiles to Pre-Generated Cyclopropenes
… cycloaddition, transition metal-catalyzed tandem reactions, multicomponent reactions, and various rearrangements and fragmentations are discussed. Chapter two describes the development of a synthetic pathway to the direct precursors to the cyclopropane-annulated 1,5-diazocin-2-one scaffolds that …
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Experimental and kinetic modelling of multicomponent gas/liquid ozone reactions in aqueous phase. Experimental investigation and Matlab modelling of the ozone mass transfer and multicomponent chemical reactions in a well agitatated semi-batch gas/liquid reactor.
… type reactors (e.g. bubble columns). The ozone reactions are hence of the type gas liquid reactions, which are complex to model since they involve both chemical reactions, which occur in the liquid phase, and mass transfer from the gas to the liquid phase. This study focuses on two aspects: mass …
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Experimental and kinetic modelling of multicomponent gas/liquid ozone reactions in aqueous phase. Experimental investigation and Matlab modelling of the ozone mass transfer and multicomponent chemical reactions in a well agitatated semi-batch gas/liquid reactor.
… type reactors (e.g. bubble columns). The ozone reactions are hence of the type gas liquid reactions, which are complex to model since they involve both chemical reactions, which occur in the liquid phase, and mass transfer from the gas to the liquid phase. This study focuses on two aspects: mass …
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Novel reaction discovery with rapid high-throughput experimentation via infrared spectroscopy and enzymatic electrochemical oxidation of alcohols
… system, more than 3000 distinctive microscale reactions were processed in under 6 months with 74% accuracy. By triaging the IR results, we prioritized time and efforts on analyzing and reproducing reactions with moderate to excellent yields. This helped to identify previously unknown …
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Kinetic modeling and automated optimization in microreactor systems
… been shown advantageous for studying chemical reactions due to their small volume, rapid mixing, tight temperature control, large range of operating conditions, and increased safety. The primary goal of this thesis is to expand the capabilities of automated microreactor systems to increase …
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Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
Cancer is one of the leading causes of deaths worldwide with 1 in 2 people estimated to develop the disease during their lifetimes. While great progress has been made in curing cancers, new therapeutics are still necessary to tackle this collection of diseases and minimise side-effects. This thesis …