Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 306 for “"multicellular"”.
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Spatial Organization of Multicellular Living Systems
… transitions, the changes in local structures in multicellular assemblies can be essential for a variety of vital processes including morphogenesis, wound healing, and cancer. In this work, we use the two invariants (volume and shear) of the deformation tensor of Delaunay triangles as a pair of …
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Multicellular self-assembly on patterned surfaces
… certain biophysical parameters that may govern multicellular assembly of a single cell type on patterned surfaces was quantitatively investigated. For surfaces patterned with small features that allow cells to sample surrounding regions through membrane protrusions, it was found that a dynamic …
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Controlling Microbial Multicellular Behaviors With Saccharide Derivatives
<p>Microbial multicellular behaviors like biofilm formation and swarming motility are known to increase their tolerance against antimicrobials. From microbial standpoint, nonmicrobicidal agents that do not impede growth are tolerable and therefore, there is a lower propensity to develop resistance …
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Role of multicellular organisation in mesoderm differentiation
What cues and signals are important for the differentiation of pluripotent cells in vitro and in vivo? During development, pluripotent cell fate decisions are spatiotemporally coordinated with changing tissue architecture. Typically, changes in tissue architecture are thought to be a downstream …
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Endogenous Stress Signaling within Human Multicellular Aggregates (Spheroids)
… (quiescence) by conversion to non-adherent multicellular aggregates. These "spheroids" can be maintained at room temperature under oxygen- and nutrient-deprived conditions for extended periods of time (weeks) as well as converted back to viable proliferating monolayers. Herein it is shown …
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Computational methods for dissecting multicellular mechanisms of complex diseases
… underlying common diseases and the resulting multicellular patterns of dysfunction. In the first project, I developed a method called scITD to investigate how cellular processes across distinct cell types coordinate in disease contexts. scITD identifies sets of genes in one or more cell types …
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Multicellular Phenotypic Studies of Single Gene Variants in Myxococcus xanthus
… and characterization of 28 genes in the multicellular bacterium <em>Myxococcus xanthus</em> using three different methods: sequence homology, transcription activation and protemoics. The results from this research extended the list of <em>M. xanthus</em> genes involved in …
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Leveraging Microtechnology to Study Multicellular Microvascular Systems and Macromolecular Interaction
Biological systems are large-scale, complex systems comprised of many hierarchical subsystems interacting physico-chemically in a dynamic and coordinated fashion. The complex interactions of subsystems (in micro-scale) lead to the formation of emergent properties (in macro-scale); these are …
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Technologies to decode the multicellular networks within the human body
… of cells to physically assemble into coordinated multicellular systems. In other words, how millions of individual cells are able to physically interact with each other in an organized way, as well as how pathogens such as viruses can exploit these interaction points in order to infect the body. …
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Impact of Vimentin Intermediate Filaments on 3D Multicellular Collective Behavior
… in a Matrigel-Alginate gel, which then grow into multicellular systems. The MCF-7 cells utilized are vimentin null, chemically inducible to form vimentin networks that interact with the other components of the cytoskeleton. These MCF-7 allow for controlled expression of mature vimentin …
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Using Deep Learning to Extract Multicellular Aggregation Features of Myxococcus xanthus
… self-organization—especially in prokaryotic multicellularity—remain incompletely understood. The bacterium Myxococcus xanthus, known for its intricate aggregation and fruiting body formation under nutrient deprivation, offers a powerful model for studying these dynamics. This thesis addresses …
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Microengineered responsive platforms for spatial and geometrical control of multicellular organizations
Living systems are composed of complex multicellular organizations containing various cell types spatially distributed in defined microenvironments. The intricate cell-cell and cell-matrix interactions in these microenvironments regulate the cell fate, differentiation of the cells, and functions of …
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Discovering the Biological Activities of Maltose Derivatives for Controlling Bacterial Multicellular Behaviors
… become a part of a team to form surface attached multicellular communities known as biofilms. Bacteria residing within biofilms are protected by a layer of slime which renders the bacteria one thousand fold more resistant to the action of antibiotics. Nearly eighty percent of bacterial infections …
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Cell seeding and proliferation simulations to plan experiments of multicellular osteogenic systems
Osteogenesis in vivo involves changes to cell density, morphology, cell-cell contacts, gene expression, and proliferation; however, the coordination of these changes is unknown. Specifically, cells undergo a morphological switch; they are proliferative, pluripotent, elongated cells early in …
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Tools for engineering multicellular systems through cell sorting and cell state detection
… that expands our ability to engineer and control multicellular systems by detecting and rewriting the cell state. We first develop a method that enables the creation of a synthetic cell state to control morphogenesis. Using inducible expression of recombinases, we show this approach can induce a …
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Intercellular flow-mediated force relaxation measurement on the three-dimensional multicellular tissue
Three-dimensional (3D) multicellular tissues are prevailing over 2D monolayer or single cells; their mechanical properties like stiffness, surface tension, and viscosity have been shown to relate to diseases like fibrosis or tumor metastasis. Multicellular tissues have been traditionally modeled as …
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Emergence of functional neuromuscular junctions in an engineered, multicellular spinal cord-muscle bioactuator
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Systems immunology frameworks link multicellular immune perturbation phenotypes and setpoints to response outcomes
… linked to antibody response, we identify a multicellular “naturally adjuvanted” human immune system setpoint more poised to respond to vaccination. Chapter 4 applies the methods developed above to a cohort of cancer patients treated with immune checkpoint inhibitors. In this work, we …
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