Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"multi-omic"”.
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Statistical methods for multi-omic data integration
… on the development of new ways to integrate multiple ’omic datasets in the context of precision medicine. This type of analyses have the potential to help researchers deepen their understanding of biological mechanisms underlying disease. However, integrative studies pose several challenges, …
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Network-based approaches for multi-omic data integration
… systems, which produces different types of omic data such as genome, epigenome, transcriptome, translatome, proteome, metabolome and interactome. Biological systems are highly dynamic and complex mechanisms which involve not only the within-level functionality but also the between-level …
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Transcriptional and Multi-Omic Heterogeneity in Glioblastoma Stem Cells
Glioblastoma Multiforme (GBM) is a disease with terrible prognosis, having a median survival time of ~12-15 months for patients undergoing current treatment regimens, and a 5-year survival rate under 10%. There is strong evidence to suggest the existence of stem like cells, which we term glioma …
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Causal Gene Prioritization Across Diverse Diseases Through Multi-Omic Data Integration
… advances now enable in-depth, high throughput multi-omic assessment (e.g. genomic sequencing, plasma proteomics) in large-scale patient and population studies. This thesis explores the application and integration of multi-omic data for the prioritization of effector genes underlying disease …
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Single-cell multi-omic data analysis with mathematical and statistical methods
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Integrative and Scalable Pipeline for Multi-omic Characterization of Biological Tissues
… and nuclei-based co-registration. We achieved multi-omic and multiplexed characterization of thick mouse brain tissues using our pipeline that enabled cell type analysis and ontogeny studies. Furthermore, effective preservation by EPIC-SHIELD allowed successful characterization of fresh frozen …
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Multi-omic Analysis of Neurodegeneration in Alzheimer’s Disease and Related Dementias
… holistically. Our research characterizes a multi-omic data set comprising 2,820,565 cells from 491 samples of prefrontal cortex across the aforementioned conditions, with all samples subjected to scRNA-seq and 63 to scATAC-seq. Leveraging this data, we conduct a multi-omic analysis of …
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Multi-omic analysis of contaminated sediments from Contrecoeur, QC on Planorbid snails
… survival, growth, reproductive output, metabolomic profile, and proteomic profile. A two-week in-situ exposure was performed on Helisoma trivolvis, and a 28-d laboratory exposure of Planorbella pilsbryi to the same sediments was completed. Snail tissue samples were collected for proteomic and …
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Multi-omic Approaches to Investigate the Inflammatory Response in Activated Macrophage Cells
… cells during clearance (ATP). In-depth proteomic analyses<br/>identified significant metabolic reprogramming along with a promotion of<br/>macrophage differentiation and polarisation, and lipidomic analysis identified<br/>significant regulation of arachidonic acid and glycerophospholipid …
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Multi-omic Studies of Neutrophils Reveal Programmed Deactivation Phenotypes After Inflammatory Stimulus
… strategies. A comprehensive time-course multi-omics study was conducted to evaluate the neutrophil response to a common human pathogen Staphylococcus aureus. This was undertaken using a model of healthy human neutrophils exposed to heat-killed, labelled S. aureus particles with the …
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Low-Input Multi-Omic Studies of Brain Neuroscience Involved in Mental Diseases
… dose of psychedelic administration. The epigenomic and transcriptomic changes induced by 2,5-Dimethoxy-4-iodoamphetamine (DOI), a subtype of psychedelics, in mouse neuronal nuclei at various time points suggest that the long-lasting effects of the psychedelic are more closely related to …
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DISSECTING THE REGULATORY LOGIC OF CELL FATE REPROGRAMMING THROUGH A MULTI-OMIC APPROACH
… reprogramming in microfluidics and temporal multi-omics to identify and resolve distinct sub-populations and their interactions. We perform secretome analysis and single-cell transcriptomics to show functional extrinsic pathways of protein communication between reprogramming sub-populations …
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Multi-omic profiling of NPQ improved nicotiana tabacum lines under uniform light conditions
… to be examined. To address this a comparative, multi-omics approach, two previously described transgenic tobacco lines (VPZ23 & VPZ34) with increased rates of NPQ relaxation were analyzed. The results indicate minimal, but directed, changes to the transformants’ transcriptome and proteome …
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Promoting multi-omic rejuvenation in human and mouse somatic cells by transient reprogramming
Ageing can be defined as the gradual decline in fitness that occurs in most organisms. The ageing process is characterised by a variety of hallmarks at the cellular and molecular levels including alterations in the epigenome. Notably in the case of the epigenome, these alterations can be measured …
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Integration of multi-omic data and neuroimaging characteristics in studying brain related diseases
… in the field of imaging genetics and radiogenomics. Studies in these fields have taken different designs and directions from genomewide associations to studying the complex interplay between genetics and structural connectivity of a wide range of brain-related diseases. Nevertheless, such …
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Computational methods for multi-omic models of cell metabolism and their importance for theoretical computer science
… models of metabolic networks. These include multi-objective optimization, sensitivity, robustness and identifiability analysis, and are applied to a set of genome-scale models. Then, I augment the framework to predict metabolic adaptation to a changing environment. The adaptation of a …
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
… this thesis I present the first comprehensive, multi-omics study comparing indolent, non-progressors with those who progressed to a range of dysplasia grades. BE is highly heterogeneous with regards to mutational load, copy-number aberrations (CNAs) and structural variants (SVs). Mutational …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
… perturbing the native cellular context in which multiple phenotypically distinct subpopulations coexist. Recent advances integrating single-cell omics with different clonal barcoding have begun to uncover features linked to the aggressive behavior of cancer clones. However, the intricate gene …
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