Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 94 for “"multi-factorial"”.
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A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, yet the metabolic mechanisms that underlie its initiation and progression remain poorly defined. Mitochondrial metabolism, particularly the function of respiratory complex I, has emerged as a key determinant of …
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Exploring the multi-factorial manifestations of joint hypermobility syndrome and the impact on quality of life.
… thesis discusses hypermobility associated with multisystemic symptoms referred to as Joint Hypermobility Syndrome (JHS). It is suggested that the multifactorial manifestations of the condition contribute to deconditioning thus impacting on the physical and mental well being of individuals with …
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Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases
… target. A significant limitation in the case of multi-factorial diseases (e.g. neurodegenerative disorders) is that effective therapy may require multi-target drugs addressing the complexity of multi-factorial pathologies. Here, single- and multi-target ligand design was investigated to discover …
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Life Satisfaction Typologies among Roman Catholic Secular Clergy: A Q Methodological Investigation
… creation of an explanatory model recognizing a multi-factorial pathway to understanding clergy life satisfaction.</p>
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Predictors of post-deployment mental healthcare utilization among active duty Marines
… returning service members, and to develop a multi-factorial model explaining the interplay among combat stress exposure, psychological distress, perceived barriers to care (stigma, logistical barriers, negative beliefs about treatment), facilitating factors (unit cohesion and post-deployment …
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Physiological assessment in talent identification within Australian football
… in talented athletes at an early age requires a multi-factorial, longitudinal approach that combines both scientific observations and intuitive judgements in the identification process. Traditionally, the measurement of physiological characteristics in the team sport environment is conducted in …
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Treatment, assessment and typologies of intimate partner violence
… highlights the importance of adopting a multi-factorial perspective in understanding the nature and aetiology of IPV and in informing policy, intervention and assessment in this domain. This thesis adheres to the empirical literature and aims to explore issues of IPV from a multifactor …
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Parental bonding, adult romantic attachment, fear of intimacy, and cognitive distortions among child molesters.
… Overall, the findings provide support for a multi-factorial model of child molestation derived from attachment theory. Limitations of the study and areas for future research are also discussed.
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The effects of fluoride levels in potable water: case studies in the Northern Cape and Mitchell's Plain
Dental caries is a multi-factorial disease that affects everyone irrespective of race, class or gender, however, the burden of the disease is often found in children from lower socio-economic backgrounds. The nature of the disease is such that it can be prevented. Various international studies on …
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Is there a difference in fat preference among differing ethnic groups and will it be a predictor of BMI?
Obesity, a multi-factorial chronic disease, affects a large portion of the population within the United States. This study was designed to determine whether or not differences in preference for high fat foods exist among ethnic groups and if these preferences would be a predictor of body mass …
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Association of nutrition education with the delay of the conversion of pre-diabetes to diabetes in hyperglycemic veterans
Diabetes is a multi-factorial, complex disease where lifestyle changes including diet and exercise can play a pivotal role in its prevention and management. This retrospective study determined the effectiveness of an outpatient nutrition education program in preventing/delaying the diagnosis of …
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Selective Mutism And Art Therapies
… situations, usually school. The causes of SM are multi-factorial. Affected children often have a history of anxiety, linguistic and motor disorders. Current therapies include a mix of anti-anxiety medication, behavioral modification therapy and anxiety reduction techniques.</p> <p> Art therapy, …
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Life after stroke: ‘a life I like’ and ‘a life to live’.
… outcome tools may not adequately measure new multi-factorial post-stroke interventions such as the ASPIRE programme, the unique contributions of this doctoral thesis to the body of knowledge are that; • An enabling culture, that includes peer support for stroke survivors and caregivers, helps …
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Neural Mechanisms Supporting Default Mode Network Regulation of Pain Sensitivity
… cognitive, affective, and genetic factors. The multi-factorial nature of pain produces substantial variations in subjective pain reports that are reflected in functional brain activity. The neural mechanisms underlying these inter-individual differences in pain sensitivity are not fully …
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Childhood Obesity and School-Based Interventions: An Evidence-Based Best Practice Guideline
… of today’s children. The causes are complex and multi-factorial; and the consequences are both chronic and serious in nature. Insulin resistance, glucose intolerance, dyslipidemia, hypertension, metabolic syndromes, fatty liver disease, menstrual abnormalities, gallstones, sleep apnea, poor body …
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Back functioning: the effectiveness of an intervention promoting good body mechanics in elementary schoolchildren
… stresses the need for primary prevention. The multi-factorial nature of the risk for developing back pain in childhood is widely accepted. On the other hand, the causative mechanisms for back pain occurrence at young age remain largely undetermined. Based on epidemiological evidence in relation …
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FRETT: Fall Risk Evaluation Tool For Traumatic Brain Injury A Master’s Thesis Project
… thesis project was to develop an evidence-based multi-factorial assessment that appropriately measures fall risk in individuals with traumatic brain injury (TBI). The thesis team created an assessment they named FRETT (Fall Risk Evaluation Tool for Traumatic Brain Injury) that evaluates …
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Perturbed equilibria of myosin binding in airway smooth muscle and its implications in airway hyperresponsiveness and asthma
… several unexplained phenomena including the multi-factorial origins of AHR, how allergen sensitization leads to AHR, and the inability in asthma of deep inspiration to relax ASM.
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Mammalian genome engineering: Fundamental investigation and method development
… 5, I describe my ongoing efforts in developing a multi-factorial Ischemia engineered cell-therapy using CRISPR/Cas9-based gene activation systems. I used synthetic biology tools that can be controlled by chemical ligands to. Temporally induce three important growth factors that control the process …
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An examination of the mentoring process: A study of the interaction between mentor and mentee in the context of an adolescent mentor program
… what occurs during the process of mentoring is multi factorial, complex and diverse. Mentoring takes place in a reciprocal way that is impacted by layered contexts. New data was gathered pertaining to the utility of several theoretical constructs that might help to explain how mentoring occurs. …
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