Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"multi-drug resistance (MDR)"”.
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A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
… Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug resistance (MDR) thus limiting and complicating treatment options. The beta lactamase resistant genes are usually encoded on plasmids and often confer resistance to other classes …
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A study on the detection of extended spectrum beta lactamase producers and class I intergrons in e. coli isolates from urinary tract infected patients at UTH.
… Beta lactamases are the primary cause of resistance to beta lactam antibiotics. These enzymes confer multi drug resistance (MDR) thus limiting and complicating treatment options. The beta lactamase resistant genes are usually encoded on plasmids and often confer resistance to other classes …
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Genotyping antibiotic resistance properties of escherichia coli and campylobacter jejuni associated with diarrhoea in young children in the Vhembe District
… children in Sub-Saharan Africa. While antibiotic resistance among enteric pathogens such as Escherichia coli (E. coli) and Campylobacter spp. is increasing, surveillance of antimicrobial resistance genes (ARG) is limited in Africa. The need for such studies in Africa was demonstrated by our …
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Using post-genomics technologies to advance understanding of liver fluke therapeutics
… stages of the liver fluke. Widespread reports of drug resistance coupled with increasing infection forecasts (due to climate change and the intensification of farming), highlight the requirement for a better understanding of drug resistance mechanisms and for novel control methods. This study …
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Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines
… and paclitaxel, can result in the emergence of multi-drug resistance (MDR) mediated by P-gp (MDR-1, ABCB1), which is an effective cellular efflux pump for both agents. This thesis was undertaken to examine the contribution of drug transport mechanisms to chemotherapeutic drug resistance, …
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DOCKING STUDIES OF CURCUMIN ANALOGS AGAINST METHIONINE AMINOPETIDASE 2 AND BIOLOGICAL EVALUATION OF LEAD MOLECULES IN COLON CELLS
… There are different challenges in developing a drug for cancer treatments which include tumor selectivity, target specificity, drug efficacy, and overcoming multi-drug resistance (MDR). Designing target specific molecules has brought better success in developing new anticancer agents. Various …
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Computational Study on MFP MexA in MexAB-OprM and RND transporter AcrB in AcrAB-TolC Efflux Pumps
… in the number of bacterial strains showing resistance to a wide variety of unrelated drugs, a phenomenon known as Multi-Drug Resistance (MDR). Molecular efflux pumps are among the major contributors to MDR, recognizing and expelling several noxious compounds into the external medium. In …
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Subcellular Localization and Activity of the Multidrug Resistance Protein 1
<p>Multi-drug resistance or MDR is a major impediment to the successful administration of chemotherapy. Broadly defined, the term MDR applies to any mechanism the cell uses to counter the effects of chemotherapeutic agents, protecting the cell at once against the toxicity of many, structurally …
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Lysin Based Antimicrobial Peptides Against Acinetobacter Baumannii
… infections. The recent rise and spread of multidrug resistant A. baumannii clones has fueled a search for alternative therapies, including bacteriophage endolysins with potent antibacterial activities. A common feature of these lysins is the presence of a highly positively charged …
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Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort
… study longitudinally investigated antimicrobial resistance amongst pneumococci colonizing the nasopharynx of South African infants immunized with the 13- valent pneumococcal conjugate vaccine (PCV13). Furthermore, the study explored strainlevel pneumococcal colonization patterns and associated …