Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"multi-cellular"”.
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Multi-Cellular And Multi-Scale Approaches For Cartilage Repair
… some of these shortcomings by developing multi-cellular and multi-scale approaches to advance technologies for cartilage repair. For instance, co-culture systems have recently been introduced as a novel tissue engineering strategy for cartilage repair. We show here that a small pool of …
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A new computational model for multi-cellular biological systems
… the mechanical properties of a cell and inter-cellular forces affect the movements we see within a tissue. It is designed to probe the relationships between cellular and tissue behaviours; such as how forces propagate through a system or the response of a tissue to applied forces. The novel …
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Quantitative Measurements of Force Distribution in Single and Multi Cellular Systems
… and task in vivo. They form the extracellular matrix (ECM). The detailed quantitative evaluation of tissue construction and tissue-cell interaction is essential for a detailed understanding of organ development and its associated malfunctions which lead to different diseases. However, …
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Biofabrication of muscular and neuronal in-vitro tissue for multi-cellular engineered living systems
… combining with the principles and properties of multiple disciplines in cellular biology at various length scales to drive composition of living material that are organized in a way that allows for the emergence of novel functionalities. Advances in this field can constitute an experimental …
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Multi-Cellular Organotypic Liver Models for the Investigation of Chemical Toxicity and Liver Fibrosis
… and failure. Liver impairment can result in multiple organ failure, hepatic encephalopathy and death. Therefore, it becomes critically important to investigate hepatotoxicity in a time, cost and resource effective manner. Our 3D liver models were validated for hepatotoxicity testing with …
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Targeting ALS: A Multi-Cellular Study on the Potential Therapeutic Role of Azole-Based Compounds
… a more targeted means of addressing ALS-related cellular dysfunction.</p> <p>Chapter 3 details the preparation and transfection of TDP-43 into SH-SY5Y (neuroblastoma) and U-2 OS (osteosarcoma) cell lines to model ALS-like cellular conditions. While Western blotting and flow cytometry were …
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Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… ovary is a highly orchestrated process involving multiple lineage determinations of ovarian surface epithelium, granulosa cells, and theca cells. While the sources of ovarian surface epithelium and granulosa cells are known, the embryonic origin(s) of theca stem/progenitor cells have not been …
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Multi-Scale Modelling of Host-Microbe Interactions: From Cell Membranes to Multi-Cellular Gut Models
… to traditional cell monolayers and stratified multi-cell type approaches, to address three microbe-related applications. Different electrochemical devices are used to monitor each for applications in host-pathogen interaction, microbiome differences in irritable bowel syndrome and microbe …
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Developing tissue engineered models of oral mucosa and oral cancer to study novel therapeutic and diagnostic techniques.
… and early invasive squamous cell carcinomas. Multi-cellular tumour spheroids were created from an oral cancer cell line to model solid expanding tumour masses. The tissue engineered models of oral mucosa and the multi-cellular tumour spheroids were used to test the behaviour of polymersomes, a …
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Mathematical Modelling of Mechanisms for Biofilm Expansion
Biofilms are multi-cellular communities of microorganisms attached to surfaces. It has been estimated that about 99% of all bacteria exist in biofilm. Thus to understand the critical role bacteria play in natural and man-made ecosystems, requires a better knowledge of these multi-cellular …
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The Design of Three-Dimensional Multicellular Liver Models Using Detachable, Nanoscale Polyelectrolyte Multilayers
… design and assembly of three-dimensional (3D) multi-cellular liver models comprised of primary rat hepatocytes, liver sinusoidal endothelial cells (LSECs), and Kupffer cells (KCs). LSECs and KCs in the liver model were separated from hepatocytes by a nanoscale, detachable, optically transparent …
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Integration of Open-Source Networks
… software allows for deployment of a mobile cellular network with lower costs, more customization, and scalable control. Two popular projects have emerged that offer varying network architectures and allow users to implement a GSM network in different capacities depending on individual needs. …
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Stiffness and Strength of Fiber Reinforced Polymer Composite Bridge Deck Systems
… stiffness and strength characteristics of the multi-cellular FRP bridge deck systems consisting of pultruded FRP shapes. A systematic analysis procedure was developed for the stiffness analysis of multi-cellular FRP deck systems. This procedure uses the Method of Elastic Equivalence to model …
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Quasi-potential analysis of multi-variate stochastic differential equations
… be responsible for stem-cell differentiation in multi-cellular organisms. To aid observations and experiments, a theoretical framework for studying these motifs using potential theory from classical physics is sometimes utilized. This thesis aims to be an expository and pedagogical introduction …
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Mathematical Models of Some Signaling Pathways Regulating Cell Survival and Death
In a multi-cellular organism, cells constantly receive signals on their internal condition and surrounding environment. In response to various signals, cells proliferate, move around or even undergo suicide. The signal-response is controlled by complex molecular machinery, understanding of which is …
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Compressive stress enhances coordinated migration of mammary carcinoma cells
… growth and stimulates production of extracellular matrix molecules. Others have also demonstrated the importance of matrix rigidity in tumor development and enhanced tumor cell adhesion by hydrostatic pressure. Yet whether growth-induced compressive stress can enhance caner cell migration …
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Vertical Village : towards a new typology of high-density low-income urban housing
… and in the process develop as responsive multi-cellular organisms, as opposed to autonomous products. This is not a new or novel idea, finding its roots in village models as early as the 14th century. The foundational components of communal living have not changed significantly in the last …
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Design and fabrication of physiologic tissue scaffolds using projection-micro-stereolithography
… microscopic architecture. Nearly all multicellular biological tissues display a hierarchy of scale. In human tissues, this means that the mechanics and function of an organ are defined by structural organization on multiple levels. Macroscopically, a branching blood supply creates a …
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Engineering LuxR-type quorum sensing proteins for new functions
… Cell-cell signalling allows for complex and multi-cellular behavior otherwise impossible with unicellular logic. However, building complex cell-cell signalling genetic circuits is currently challenged by a lack of tools for the fine-tuning and control of quorum sensing systems. Although …
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Advanced in Vitro Models for Studying Bone Physiology
… hierarchical structure. The presence of complex multi-cellular organization within opaque mineralized matrix makes it challenging to use conventional methods to study in vivo bone physiology even using model animals. To address this challenge, numerous in vitro models have been developed to study …
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