Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"multi- omics integration"”.
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Pan-Cancer Analysis of RNA Dysregulation, Somatic Mutations, and Matrix Stiffness using Bioinformatics Approaches
… different dimensions of cancer biology through multi-omics integration and computational approaches. The research is divided into three main projects. First, I developed OncoDB, an interactive database to analyze gene expression, methylation patterns, and viral interactions in cancer, revealing …
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3D Chromatin Structure and Gene Regulation: Integrated Genome Structure, Transcriptomics and Epigenetics
… conformations, integrate them with functional genomics, and make them broadly accessible. I present a framework that combines Hi-C with expression quantitative trait loci (eQTL) data to identify statistically significant contacts and reconstruct ensembles of single-cell structures. These analyses …
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Non-linear Multi Omics Data Integration Method Using Conditional Variational Autoencoders
… have enabled the study of diseases through multi-omics data, which combines information from genome, epigenome, transcriptome, proteome, and metabolome levels. Unlike single-omics approaches that provide limited insights, multi-omics integration offers a comprehensive understanding of …
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Multi-omics Investigation into Alzheimer's Disease: Functional Mechanism and Early Detection
Alzheimer’s disease (AD), a multi-factorial and highly heritable condition, stands as the foremost contributor to dementia. Despite its early discovery and extensive studies, the underlying pathogenesis of AD remains incomplete. This thesis addresses critical aspects of AD through multi-omics …
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Mixture Model Approaches to Integrative Analysis of Multi-Omics Data and Spatially Correlated Genomic Data
… gene activities through jointly analyzing multiple types of genomic data from different platforms (vertical integration), or improve the power of a study through aggregating the same type of genomic data across studies (horizontal integration). In this dissertation, we propose statistical …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… (DSS). In addition, through system biology and multi-omics integration (transcriptomics and proteomics), we have demonstrated the cytoprotective properties of n-3 PUFA in IPEC-J2 cells against LPS-induced inflammatory and metabolic damage. Specifically, in these cells, we have identified that …
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Exploring metabolomics through NMR: from early life to aging
Metabolomics occupies a unique yet demanding position in translational research. Its proximity to phenotype and its sensitivity to clinical and environmental perturbations make it a powerful tool for understanding biological processes in real-world settings. At the same time, this very sensitivity …
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Machine learning enabled bioinformatics tools for analysis of biologically diverse samples
… decades, the generation of vast volumes of multi-omics data, spanning a broad range of phenotypes. Development of advanced bioinformatics tools to identify informative biomarkers from these data becomes increasingly important. These tools are crucial to extract meaningful biomarkers from …
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UNCOVERING LNCRNA-CHROMATIN INTERACTIONS SHAPING HUMAN MONOCYTE TO MACROPHAGE DIFFERENTIATION
… Ligated and sequenced (RADICL-seq). Using a multi-omics approach, we aim to identify regulatory roles of chromatin-associated lncRNAs in a dynamic model of monocyte to macrophage differentiation, a key process in innate immunity. To achieve this, we generated a comprehensive transcript …