Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 137 for “"multi drug-resistant"”.
-
TARGETING MULTI-DRUG RESISTANT PATHOGENS WITH NOVEL ANTIMICROBIAL PEPTIDES
… In the United States alone, antibiotic-resistant bacteria infect at least two million people and kill around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant Staphylococcus aureus (MRSA) according to a report published in …
-
Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
… nosocomial pathogens that can be intrinsically resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell membrane (CM) stressors like daptomycin (DAP), a front-line drug for multi-drug resistant …
-
The Dynamics of Multi-Drug Resistant Organisms: Modeling Nosocomial Infection Control Measures
… the most efficient methods to combat it. Though drugs do exist to treat them, they are known to be highly resistant and have proven to be a reoccurring problem in hospitals, posing an increasing medical burden. Infection control measures have been implemented in order to reduce their impact and …
-
Institutional and Patient Level Predictors of Multi-Drug Resistant Healthcare-Associated Infections
Healthcare-associated infections (HAI) caused by multi-drug resistant organisms (MDRO) are an important patient safety concern resulting in a substantial financial and clinical burden. This dissertation aims to contribute to the evidence base on institutional and patient level factors that predict …
-
Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… and other ESKAPE pathogens (including carbapenem-resistant Acinetobacter baumannii). Interestingly, these analogues were resistant to enzymatic degradation in the presence of recently reported D-stereoselective peptidases. <br/><br/>Secondly, brevicidine represents a promising candidate for …
-
Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
… development of new antimicrobials to treat these multidrug-resistant pathogens has not kept pace with the rapid emergence of resistance to current antimicrobials. Antimicrobial drug development through the traditional <em>de novo</em> process is a risky venture given the significant financial and …
-
Biochemical, Structural, And Drug Design Studies Of Multi-Drug Resistant Hiv-1 Therapeutic Targets
… the structural mechanisms that lead to multi-drug resistance to HIV-1 protease and integrase inhibitors. </p> <p>Proper proteolytic processing of the HIV-1 Gag/Pol polyprotein is required for HIV infection and viral replication. This feature has made HIV-1 protease an attractive target …
-
Molecular differentiation of multi-drug resistant mycobacterium tuberculosis complex isolated from three provinces in Zambia
Multidrug-resistant tuberculosis (MDR-TB) is a disease caused by an acid-fast staining pathogenic bacterium, Mycobacterium tuberculosis that is resistant to at least isoniazid (INH) and rifampicin (RIF), the two most potent TB drugs. Drug-resistant tuberculosis poses a significant problem for …
-
Molecular differentiation of multi-drug resistant mycobacterium tuberculosis complex isolated from three provinces in Zambia
Multidrug-resistant tuberculosis (MDR-TB) is a disease caused by an acid-fast staining pathogenic bacterium, Mycobacterium tuberculosis that is resistant to at least isoniazid (INH) and rifampicin (RIF), the two most potent TB drugs. Drug-resistant tuberculosis poses a significant problem for …
-
Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
Background: Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and effectiveness with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated …
-
Antibacterial activity of the crude extract and fractions of spirostachys africana against multi-drug resistant bacteria
… diseases, specifically those caused by multi-drug resistant bacteria in the last decade has made it a necessity to investigate a variety of antimicrobial drug sources, such as plants. Medicinal plants have played a significant role in drug discovery for western pharmaceuticals recently …
-
ST-1 VISA/DAP-R CA-MRSA INTEGRATED OMICS: A FIRST REPORT OF HYPER-VIRULENCE AND MULTI-DRUG RESISTANT SUPERBUG
Methicillin Resistant Staphylococcus aureus (MRSA) represents a global human health problem for its rising multi-drug resistance phenotype, involvement in nosocomial infections and outbreaks worldwide, and for its capability to spread in both hospital (HA-MRSA) and community (CA-MRSA) environments. …
-
Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
… them a reservoir of bioactive molecules for drug discovery. This study seeks to identify effective potential antibiofilm compounds from a query dataset compiled from two African natural product databases (SANCDb and AfroDb). A database of known antibiofilm compounds was created from ChEMBL, …
-
Costing analysis of levofloxacin as antibiotic prophylaxis for pediatric household contacts of multi-drug resistant tuberculosis patients in a South African setting
… estimated that there were approximately 11 000 multi-drug resistant (MDR) TB cases in South Africa. Despite having very clear guidelines on TB treatment programs and management, availability of inexpensive diagnostic tests, curative and preventive therapies, and the widespread use of the BCG …
-
Crystallographic, Molecular Dynamics, And Enzymatic Studies Of Multi-Drug Resistant Hiv-1 Protease And Implications For Structure Based Drug Design (project 1); Crystallographic Studies Of Human Myelin Protein Zero (project 2)
<p>Under drug selection pressure, emerging mutations render HIV-1 protease drug resistance, leading to the therapy failure in anti-HIV treatment.Tthe multidrug-resistant 769 (MDR) HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, 90) is selected for the present …
-
The Potential Role of Cathelicidin Peptides for the Treatment of Lower Respiratory Tract Infections
… lung dysfunction. The development of antibiotic resistant bacterial infections has limited the effectiveness of current therapeutics and is particularly concerning in the setting of chronic bacterial infections, such as observed in cystic fibrosis and ventilator-associated pneumonia. The …
-
The characterization of two novel class II lanthipeptides from Thalassomonas viridans by heterologous expression in Escherichia coli
… With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the discovery and development of novel antimicrobial agents. In the past, natural products have been a source of successful drug candidates for treating diseases. However, the rate of natural …
-
The characterization of two novel class II lanthipeptides from thalassomonas viridans by heterologous expression in escherichia coli
… With the rising emergence of antibiotic-resistant microorganisms, there is an urgent need for the discovery and development of novel antimicrobial agents. In the past, natural products have been a source of successful drug candidates for treating diseases. However, the rate of natural …
-
Novel collective prey evasion response of Pseudomonas aeruginosa PAO1 to soil micropredator Myxococcus xanthus DK1622
… is on the rise because of the threat of multi-drug resistant bacteria. Looking at the hunting strategy of soil-based bacterial micropredators is one avenue of exploration. Myxobacteria are soil predators with a wide prey range including Gram-negative and Gram-positive bacteria, fungi, and …
-
The Use of C. Elegans to Identify Mutations That Confer Drug Resistance, Using Hemiasterlin as an Example
… over-expressing efflux pumps associated with multidrug resistance are not resistant to the toxic effects of hemiasterlin. Because of these characteristics, hemiasterlin or hemiasterlin derivatives have been involved in several clinical trials. The Roth lab set out to discover novel modes of …
Page 1 of 7