Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"mucosal immunology"”.
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Transdisciplinary Strategies for the Characterization of Mucosal Immune Responses to Enteric Pathogens
The gastrointestinal mucosal immune system has the daunting task of maintaining immune homeostasis by eliminating potentially harmful microorganisms and limiting tissue injury while inducing tolerogenic responses to luminal antigens including innocuous food, commensal bacteria and self-antigens. …
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Lymphocyte subset variability between human lymphoid tissues
Most adaptive immune lymphocytes are in the lymphoid tissues. However, studies of human lymphocytes to date have primarily investigated cells from the blood, and lymphoid tissues remain poorly studied. This thesis explores the hypothesis that there is local variation of B cell subsets between the …
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Probiotic Modulation of Mucosal Immune Responses in an In Vitro Co-Culture Model
… modulation of the gut immune system. Gut mucosal macrophages play a pivotal role in driving mucosal immune responses. The local environment and macrophage subset determine immune response: tolerance, associated with an M2-like, regulatory macrophage phenotype and inflammatory activation …
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Characterizing Host Protective Immune Responses to the Parasitic Worm Heligmosomoides polygyrus
Intestinal roundworms cause chronic debilitating disease in humans and livestock. The lack of vaccines and the emerging drug resistance only increase the need to better understand worm-host interactions. H. polygyrus larvae induce an intestinal granuloma response whereby immune cells, mostly …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where …
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The ontogeny and function of intestinal dendritic cells
The intestinal mucosa presents a huge surface area to the external environment and the intestinal immune system is continually exposed to a wide array of foreign antigens derived from resident intestinal microbiota as well as dietary constituents, including food proteins. In order to maintain …
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Activation and Maintenance of Intestinal Intraepithelial Lymphocytes (IELs)
The intestinal tissue is charged with a delicate immunological task. The intestinal immune system needs to be tolerant towards nutrients and microbiota present in the intestinal lumen, while simultaneously detecting and responding to dangers such as pathogens. A single-cell layer of intestinal …
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The structures of secretory IgA in complex with human and bacterial Fc receptors and functional implications for mucosal host-pathogen interactions
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… receptor that transports secretory IgA across mucosal epithelia, was abundantly expressed and hormonally regulated in epithelial cells of the vagina and endocervix. FcRn, a receptor originally characterized in the placenta and gut where it confers passive immunity from mother-to-child via …
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The Role of Dysfunctional Na+/H+ Exchange in the Development of Dysbiosis and Subsequent Colitis
The last half-century has seen a dramatic and alarming rise in the incidence of autoimmune disease in industrialized nations too rapid to be accounted for by genetics alone. Among those, Inflammatory Bowel Disease (IBD) has risen from a western disease affecting industrialized populations to an …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
The intestine, a dwelling place for trillions of commensal bacteria, is constantly exposed to numerous ligands and antigens from foods and microbiota. Intestinal homeostasis involves a balance between anti-inflammatory and pro-inflammatory signals. Intestinal epithelial barrier, commensal bacteria, …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
The intestine, a dwelling place for trillions of commensal bacteria, is constantly exposed to numerous ligands and antigens from foods and microbiota. Intestinal homeostasis involves a balance between anti-inflammatory and pro-inflammatory signals. Intestinal epithelial barrier, commensal bacteria, …
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ON THE NOSE: MUCOSAL IMMUNE RESPONSES DURING EQUINE HERPESVIRUS TYPE 1 INFECTION
The mucosal immune system is the first line of defense for a broad range of pathogens that greatly impact humans and veterinary species. The respiratory tract is the entry site of many high morbidity and mortality animal viruses, including equine herpesvirus type 1 (EHV-1). EHV-1 is endemic in …
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T-cells in COPD to help or harm? A study of T-cells in COPD patients and related aspects of T-cell function in vitro
Chronic obstructive pulmonary disease, COPD, is manifested by chronic airflow limitation due to inflammation and tissue destruction in the lungs. COPD is caused primarily by smoking and with increasing cigarette consumption in the world, the prevalence for COPD will most probably increase in the …
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Mapping the Gut Microbiota and its Protective Functions Against Bacterial Enterocolitis
The human gastrointestinal tract is colonised by trillions of microbes that actively impact the health of the host. This ecosystem, known as the gut microbiota, varies in composition between individuals and is associated with outcomes of many diseases. However, the underlying physiology of these …