Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mucosal immunization"”.
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… immune responses to antigens, particularly for immunizations targeting the tolerogenic mucosal tissues, which are more biologically relevant for protective immunity against pathogens transmitted by the mucosal routes. Adjuvants possess the inherent capacity to bridge innate and adaptive immune …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
… (ID) injection) and induce systemic but rarely mucosal immunity. Novel vaccination strategies capable of inducing both systemic and mucosal immune responses could greatly reduce infection and morbidity. One such strategy is DNA vaccination whereby the antigen is synthesized in vivo after direct …
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Expression Of Cholera Toxin B Subunit-rotavirus Nsp4 Enterotoxin Fusion Protein In Transgenic Chloroplasts
… budding from cells, provides a new approach for mucosal immunization. Protein expression through chloroplast transformation system offers a number of advantages like high level of transgene expression, transgene containment via maternal inheritance, lack of gene silencing and position effect due …
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INTERNALIZATION AND IMMUNOGENICITY OF MUCOSALLY-ADMINISTERED SOLUBLE AND PARTICULATE ANTIGENS
The mucosal surfaces of the gastrointestinal, respiratory, and reproductive tracts, serve as portals of entry for the majority of pathogens. Systemic (parenteral) vaccines can provide protection against some mucosal pathogens, like poliovirus and influenza virus; however, they do not induce mucosal …
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Modulation of Immune Responses Induced by Vaccination Against Bovine Respiratory Syncytial Virus
… infects the lung mucosa, vaccines that induce mucosal immunity are desirable. Parenterally delivered vaccines typically induce systemic immunity with low mucosal immune response levels, whereas mucosally delivered vaccines induce systemic and mucosal immunity. However, upon mucosal delivery …
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… antigens. While a single intravenous immunization of α-GalCer strongly activates NKT cells, multiple doses by this route are well documented to induce anergy in NKT cells. Anergy is defined as the deficiency in NKT proliferation and cytokine production, including IL-4 and IFNγ. …