Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"mucosal adjuvants"”.
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Mucosal adjuvants and their mode of action in the female genital tract
… a need for development of potent vaccine adjuvants. Although a few adjuvants are included in the licensed vaccines, they are all administered systemically and their mode of action is poorly defined. In this thesis we have identified two new potent mucosal adjuvants for induction of …
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Evaluation of the novel P particle vaccine candidate against human norovirus using the gnotobiotic pig challenge model
… (LoPP) or VLPs, 250 µg P particles (HiPP), or adjuvants only intranasally at post-inoculation day (PID) 0, 10, and 21. Monophosphoryl lipid A and chitosan were used as mucosal adjuvants. At PID 28, a subset of pigs were orally challenged with 10 median infectious doses (ID50) NoV. NoVPO, LoPP, …
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Tailored influenza virus vaccines for both the young and old: Vaccine Efficacy of Whole Inactivated Vaccines bearing Immunomodulatory Adjuvants or Multimeric peptides
… and CYT-IVAC~IL-23/HA serve as potent mucosal adjuvants in young adult mice elicited significantly high levels of mucosal IgA antibodies and afford superior protection against lethal virus challenge. Our Flt3L/HA formulation was the most effective stimulator of systemic anti-viral …
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A study of the contribution of mast cells to vaccination - Regulatory functions of Fc gamma receptors
… connective tissue mast cells (CTMCs), but not mucosal mast cells (MMCs), were found to be activated by CTA1-DD/IgG complexes. This effect was mediated by Fc gamma RIIIA, an activating receptor that has been described to be only expressed on connective tissue mast cells. Indeed, Fc gamma …