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Showing 1 to 20 of 36 for “"mucoid"”.
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IN VITRO AND IN VIVO ACTIVITY OF DINB: ROLE IN MUCOID CONVERSION OF PSEUDOMONAS AERUGINOSA
… aeruginosa undergoes a phenotypic change called mucoid conversion in the lungs of chronically infected cystic fibrosis (CF) patients. This phenotypic change leads to the production of the exopolysaccharide alginate, which gives the organism a selective advantage in the CF lung, as alginate …
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The Effect of Environment on Virulence Factors and Resistance of Mucoid Strains of Pseudomonas Aeruginosa
M7, a mucoid variant of Pseudomonas aeruginosa NCTC 6750 isolated in vitro, was compared to its non-mucoid parent strain (WT). Their nutritional requirements showed slight differences. The non-mucoid had a growth rate advantage over the mucoid variant. M7 retained its mucoid character both in batch …
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REGULATION OF ALGINATE AND PSL POLYSACCHARIDE EXPRESSOIN IN CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSA
… suffering from long-term chronic infections are mucoid, overexpressing the polysaccharide alginate. Alternatively, most environmental and acute infection strains are non-mucoid and produce an alternative polysaccharide, designated Psl. Both alginate and Psl polysaccharides promote biofilm …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΚΑΙ ΤΟ ΧΑΡΑΚΤΗΡΙΣΜΟ ΤΗΣ ΕΞΩΚΥΤΤΑΡΙΑΣ ΟΥΣΙΑΣ (SLIME) ΒΑΚΤΗΡΙΑΙΜΙΚΟΥ ΒΛΕΝΝΩΔΟΥΣ ΚΑΙ ΘΥΓΑΤΡΙΚΟΥ ΜΗ ΒΛΕΝΝΩΔΟΥΣ ΣΤΕΛΕΧΟΥΣ PSEUDOMONAS AERUGINOSA
THE FIRST CASE OF A HEAVILY MUCOID STRAIN (MS) OR PSEUDOMONAS AERUGINOSA BACTEREMIA IS REPORTED IN A HOSPITALIZED 78-YR-OLD WOMAN WITH DRUG-INDUCED HEPATITIS DUE TO ANTITUBERCULOUS THERAPY. A REVERTANT NON MUCOID VARIANT (RNMV) FROM THE PARENTAL MS WAS OBTAINED BY SERIAL PASSAGE ON TRYPTICASE SOY …
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Ιστοπαθολογικές αλλοιώσεις σε ποντίκια μετά από ενδοπεριτοναϊκή χορήγηση της γλυκολιποπρωτεΐνης (G.L.P.) του Slime της pseudomonas aeruginosa
… methods Sensakovic and Bartell 1974) from a non mucoid strain and a revertant non mucoid variant of Pseudomonas aeruginosa. Alginate also was obtained from a mucoid strain of Pseudomonas aeruginosa. The histopathology of mice induce by a single intraperitoneal (ip) LD₅₀ dose of there substances …
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ROLE OF CRC IN THE REGULATION OF ALGINATE IN PSEUDOMONAS AERUGINOSA
… pulmonary disease (COPD) lung environments, mucoid strains often appear as a result of alginate overproduction. Such mucoid conversion is associated with the establishment of a chronic pulmonary infection. Alginate confers resistance to phagocytosis and has other pathogenic properties. The …
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A comparative and phylogenetic analysis of the genome of Pseudomonas aeruginosa
… example of this phenomenon is the switch to the mucoid phenotype resulting from frame-shift mutations in the mucA gene leading to overproduction of alginate. In this work, we have identified this switch in phenotype as a marker for host adaptation by the bacterium to the CF lung environment and …
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Studies on T-OMP and the development of antimicrobial tolerance in <i>Pseudomonas aeruginosa</i> PAO1
… distinct colonial morphologies were observed, mucoid and non-mucoid. An increase in the cell surface hydrophobicity was noted between the mucoid and non-mucoid cultures, which indicated a loss or reduction in the B-band OPolysaccharide. However, there were no observable differences in the …
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Alternative regulation of the alginate algD operon by an activated AlgB in nonmucoid Pseudomonas aeruginosa is dependent on Sigma 54
… by Pseudomonas aeruginosa, which causes a mucoid phenotype, is a major virulence factor associated with chronic pulmonary infections in cystic fibrosis patients. Expression of the algD operon for alginate biosynthesis requires three major regulators in association with the ECF sigma factor, …
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The Population and Activity of Airway Macrophages in Patients Requiring Continuous Mechanical Ventilation
… of the adherent cell population from highly mucoid specimens. Many adherent cells failed to demonstrate phagocytosis. Those that did demonstrated above normal phagocytic ability when challenged with Aspergillus fumigatus conidia. The cellular content of the specimens demonstrated a …
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Prospective Clinical Study of Posterior Cruciate and Meniscofemoral Ligaments of the Knee Joint From Surgical Biopsies and Morphometric Analysis From Thiel Embalmed Knees
… showed moderate collagen disorientation and mucoid degeneration with fewer neural structures within the ligament compared to painful knees. Furthermore, for painful knees, severe collagen disorientation with moderate mucoid degeneration and more neural structures were present in valgus than …
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Regulating rsmA Expression in Pseudomonas aeruginosa
… protein levels, revealed varying results in nonmucoid versus mucoid backgrounds. Phenotypic assays were performed to characterize this unknown transporter and develop a putative mechanism as to how MtpX affects <em>rsmA</em> expression.</p>
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Factors that enhance the ability of Pseudomonas aeruginosa to resist the action of antibiotics
… exposure resulted in phenotypically distinct mucoid and non- mucoid colony morphotypes, which were clearly observed on amikacin-free nutrient agar. Some of these selected morphotypes showed from the MIC and MBC data a high-level resistance to the antibiotic when left without antibiotics. The …
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CONTROLLING BIOFILM AND PERSISTER CELLS BY TARGETING CELL MEMBRANES
… cells of both P. aeruginosa PAO1 and PDO300 (a mucoid strain) in a dose-dependent manner. Killing effect on biofilm and persister cells was observed at the concentrations without significant toxicity to IB3-1 cells originated from human lung tissues. </p> <p>We also demonstrated that TN-5, a …
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ΧΑΡΑΚΤΗΡΙΣΜΟΣ ΤΗΣ ΓΛΥΚΟΛΙΠΟΠΡΩΤΕΙΝΗΣ (G.L.P.) ΤΟΥ SLIME ΤΡΙΩΝ ΠΡΟΤΥΠΩΝ ΣΤΕΛΕΧΩΝPSEUDOMONAS AERUGINOSA ΚΑΙ ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ ΑΥΤΗΣ ΩΣ ΠΡΟΣ ΤΙΣ ΟΜΟΙΟΤΗΤΕΣ Η ΤΙΣ ΔΙΑΦΟΡΕΣ ΜΕ ΤΟ ΛΙΠΟΠΟΛΥΣΑΚΧΑΡΙΤΗ (L.P.S.) ΤΟΥ ΜΙΚΡΟΟΡΓΑΝΙΣΜΟΥ
… OUTER MEMBRANES WERE OBTAINED FROM A SMOOTH NON MUCOID PSEUDOMONAS AERUGINOSA STRAIN PAC-IR AND ITS TWO ROUGH MUTANTS PAC 557 AND PAC 605. ELECTROPHORETIC ANALYSIS ON SDS- POLYACRYLAMIDE GELS AND STRAINING WITH SILVER AND COOMASSIE BLUE SHOWED DIFFERENT PROFILES BETWEEN LPS SLIME AND OUTER …
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Development of a flagellin-based multivalent vaccine against Pseudomonas aeruginosa
… complement-mediated killing of nonmucoid bacteria, they were significantly less effective with mucoid isolates. Mice immunized with OprF311-341-OprI-Flagellins had a significantly lower bacterial burden three days post-challenge and cleared the infection at a significantly faster …
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Studies on pneumococci isolated from children in the Sheffield area.
… pneumoniae) was improved, and gave large mucoid colonies, when incubated in an anaerobic environment containing extra CO2. Both reduction of oxygen tension, with a reduction in the formation of peroxides, and a variable requirement for CO2 were necessary for optimal recovery of strains …
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Evaluation of long-term effects of early auditory deprivation: an animal model for otitis media
… level associated with the presence of the mucoid mass. Upon adulthood, prior to any other testing, open-field behavior was examined; focussing on exploration and re-exploration tendancies, reaction to novelty, and habituation to new environments. No consistent differences were noted for …
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Structural Insights into Modification and Export of the Pseudomonas aeruginosa Alginate Exopolysaccharide
… lung infections, P. aeruginosa converts to a mucoid phenotype by constitutive expression of the AlgU/T regulon. As a result, P. aeruginosa overproduces the alginate exopolysaccharide, leading to worse patient outcomes.In the cytoplasm, the process of alginate biosynthesis begins with …
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