Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"mucociliary"”.
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Risk Factors Associated With The Mucociliary Apparatus In Intensive Care Patients
… bronchus of intensive care unit patients. The mucociliary apparatus is the main airway defence mechanism protecting the lungs from respiratory infections. It is vital in intubated patients, as they lack the back up clearance mechanism normally provided by the cough reflex. Ciliary coverage and …
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Nebulized Hypertonic Saline-Triggered Increase in Mucociliary Clearance Rate is Mediated by the Nervous System
… into the airway lumen and, thus, increasing mucociliary clearance (MCC). However, recent research has also demonstrated that HTS-triggered increase in ASL height is mediated by the nervous system, whereby HTS stimulates sensory neurons to promote active secretion of ASL via airway epithelia. …
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The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa
… electromagnetic fields (EMF) on human nasal mucociliary transport and to determine the pathophysiology of ciliary beat frequency (CBF) during an EMF-induced change. Human nasal mucosa cells were exposed to a 1.8 GHz EMF (SAR= 1.0 W/kg), and CBF was analyzed using an optical flow technique …
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AIRWAY SURFACE HYPERVISCOSITY AND DEFECTIVE MUCOCILIARY TRANSPORT BY IL-17/TNF-ALPHA ARE CORRECTED BY BETA-ADRENERGIC STIMULUS
The fluid covering the surface of airway epithelia represents a first barrier against pathogens. The chemical and physical properties of the airway surface fluid are controlled by the activity of ion channels and transporters. In cystic fibrosis (CF), loss of CFTR chloride channel function causes …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… pathogens from the lungs by a process known as mucociliary clearance. Current treatment strategies for patients with asthma, COPD and other inflammatory airway disorders emphasize a combined therapy involving inhaled corticosteroid (ICS) and long-acting β2-agonists (LABA) aimed at reducing …
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Novel endoscopes for microscopic assessment of airway clearance using micro-optical coherence tomography
… particles trapped within mucus. Impairment of mucociliary clearance (MCC) can lead to life-threatening airway narrowing and lung infections, and is a major cause of morbidity and mortality in patients with cystic fibrosis, primary ciliary dyskinesia and chronic obstructive lung disease. …
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The biochemical characterisation of respiratory mucus & mucins in normal, asthma & COPD
… enable it to be transported out of the lungs by mucociliary clearance.
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
… airways dehydration, thickened mucus, impaired mucociliary clearance and is thought to be a major contributor to the pathogenesis of lung disease. Previous work has shown that QUB-TL1, an active site directed inhibitor of trypsin and trypsin-like enzymes, reduces ENaC-mediated sodium absorption …
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Ultrastructure and function of respiratory cilia in critical illness
… a problem in the intensive care unit (ICU). The mucociliary transport system is the major defence mechanism against such infection and whilst its efficiency has been shown to be decreased in ICU patients there are few reports in the literature describing the ultrastructure of the respiratory …
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Effect of Smoke Exposure and Ethanol Ingestion on Anti-Pneumococcal Host Defenses
… into the lungs. This EtOH induced defect in host mucociliary defense was dose dependent, and was intensified by concurrent smoke exposure. The increased movement of pneumococci into the lungs of the smoke-exposed and EtOH-fed rats correlated to deficits in the ability of their ciliated tracheal …
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Regulation of airway epithelial cell migration by the cystic fibrosis transmembrane conductance regulator.
… particles in inspired air and the lung tissue. Mucociliary clearance is an essential function of the airway epithelium to protect against infection and airway damage. By this process, inhaled particles are trapped in the mucus lining the airway and propelled out of the airways by ciliary …
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Cirrhosis-Induced Defects in Innate Puemonary Defenses Against Streptococcus Pneumoniae
… defenses analyzed within this research included mucociliary clearance, early pre-neutrophil- and later neutrophil-mediated defenses, and in vivo complement deposition inside the lungs. Cirrhosis was induced in male Sprague-Dawley rats by weekly gavage with carbon tetrachloride, whereas control …
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Primary Ciliary Dyskinesia: An Epidemiological Exploration. Furthering our understanding of the burden of disease in PCD
… by dysfunctional motile cilia and abnormal mucociliary clearance. In recent years, there have been significant advancements in the understanding of PCD including, but are not limited to, disease frequency estimates in specific ethnic groups and geographical regions, the expansion of …
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Μελέτη της λειτουργικότητας του κροσσωτού επιθηλίου του βλεννογόνου του ιγμόρειου άντρου μετά από έκχυση ραδιοϊσοτόπου 99Tcm-MAA σε ασθενείς με χρόνια ιγμορίτιδα και συσχέτιση με ευρήματα αξονικής τομογραφίας
… μεταφοράς του βλεννοκροσσωτού επιθηλίου (mucociliary transport velocity – MTV) που εκτιμάται με το ρινοσπινθηρογράφημα θεωρείται μια αξιόπιστη μέτρηση της κάθαρσης του βλεννοκροσσωτού επιθηλίου. Σχεδιάσαμε την παρούσα μελέτη με σκοπό τη διερεύνηση, μέσω του ρινοσπινθηρογραφήματος, της …
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The development of novel strategies to modulate epithelial sodium channel (ENaC) activity in chronic obstructive pulmonary disease (COPD)
Impaired mucociliary clearance (MCC) which leads to infection, inflammation, and progressive lung damage is a hallmark of the chronic bronchitis (CB) phenotype in COPD, and the hydration status of the airways has been indicated as the main factor affecting this disorder. Inhibition of ENaC function …
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Identification of a ciliary defect associated with pulmonary nontuberculous mycobacterial disease
… predisposition because diseases with defects of mucociliary transport have high rates of PNTM disease that increase with age, suggesting a direct connection between airway epithelial function and PNTM disease. I found that PNTM patients have a distinct respiratory epithelial phenotype ex vivo and …
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Multisystem Effects of Mold Inhalation: A Convergence on the Central Nervous System
… immunity, cleared from the lung by the mucociliary escalator, swallowed, and excreted through the gastrointestinal tract. Molds produce many mycotoxins which enter enterohepatic recirculation with known toxic effects, including intestinal epithelial disruption. Mycotoxin concentrations …
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Comparison of Potential Salmonella Portals of Entry and Tissue Distribution Following Challenge of Poultry
… oral ingestion, due to the presence of the mucociliary clearance was evaluated. Suspension in 1% mucin failed to increase the infectivity at any dose of Salmonella when compared to OR administration without mucin and intratracheal (IT) challenge, which was also recovered from lung tissue. IT …
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Understanding the Collective Dynamics of Motile Cilia in Human Airways
… and one that is central to this thesis, is mucociliary clearance in human airways: A carpet of motile cilia helps keeping the cell surface free from pathogens and foreign particles by constantly evacuating from lungs, bronchi, and trachea a barrier of mucus. The question of how motile cilia …
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
… defective cilia have a reduced capacity for mucociliary clearance of inhaled toxic particles. Loss of TAp73 function and the concomitant increase in sensitivity to apoptosis may therefore further enhance vulnerability to inhaled pathogens or pollutants, highlighting a possible role for TAp73 …
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