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Showing 1 to 20 of 26 for “"mucoadhesive"”.
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PRINTING MUCOADHESIVE AND ORODISPERSIBLE FILMS FOR THE PERSONALIZATION OF THERAPY
… forms such as orodispersible films (ODF) and mucoadhesive films (MAF) are increasingly recognized as valuable tools for addressing unmet therapeutic needs in populations requiring flexible, easy-to-administer medicines, such as paediatric and dysphagic patients. Among the proposed …
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Mucoadhesive buccal tablets for the delivery of nicotine and Delta9-tetrahydrocannabinol.
Nicotine replacement therapy (NRT) is restricted to monotherapy with either a type A product providing rapid nicotine delivery or a type B product providing controlled nicotine delivery. Biphasic buccal adhesive nicotine tablets have been prepared with the intention of providing a combination of …
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Investigation of liquid sodium alginates as mucoadhesive bandages coating the oesophageal mucosa and protecting it from gastric reflux
Gastro-oesophageal Reflux Disease (GORD), is generally caused by excess gastric reflux back to the oesophagus where damage to the mucosa results in injury. GORD is a very common disease in western countries, more than a quarter of western people are suffering from this disease and there is a trend …
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Elucidating bioadhesive processes in nasal drug delivery systems
Mucoadhesive formulations have been used to increase the residence time and improve bioavailability of nasal dosage forms. The exact nature of the interplay between formulations and the mucus layer has not been defined, although theories have been proposed suggesting that certain characteristics …
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A Novel IN SITU Gel for Sustained Drug Delivery and Targeting
… pH changes. Chitosan has also been shown to be mucoadhesive due to its polycationic nature. Hydrophobic lipids, such as glyceryl monooleate (GMO), have also been used as matrix material for sustained drug delivery of both hydrophilic and hydrophobic drugs. GMO forms liquid crystalline cubic …
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Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
… assessed by SEM, cytotoxicity by MTT method and mucoadhesive properties by mucin association. In all cases, freeze-drying prior to nebulization did not affect EE%, NE or NEED%. In CHT, MPs RIF encapsulation efficiency (EE%) decreased with increasing CHT concentration (viscosity) and CHT-MP NEED% …
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Chitosan-Cellulose Nanocrystal Polyelectrolyte Complex Particles: Preparation, Characterization, and In Vitro Drug Release Properties
… complexes (PECs) between chitosan, a mucoadhesive, intestinal mucosal permeability-enhancing polysaccharide, and cellulose nanocrystals, rod-like cellulose nanoparticles with sulfate groups on their surface, have potential applications in oral drug delivery. The purpose of this …
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Development of a platform for nasal delivery of peptides and vaccines using powder carriers based on starch/poly(acrylic) acid
… 974P) was used as powder carrier to amplify the mucoadhesive capacity of the formulation. In a first part of the study, the Amioca®/Carbopol® powder formulation was subjected to a heat treatment procedure. After heat treatment the water-absorbing capacity, viscosity and elasticity of the …
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Novel Applications of Hot-Melt Extrusion Technology
… of formulation variables on the extruded mucoadhesive films. It was observed that each independent variable influenced one or the other film characteristics either alone or in combination. It is only after such analysis that an optimized system with desired quality attributes could be …
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Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery
… poor intestinal absorption. Orally administered mucoadhesive nanoparticles have been shown to interact with the intestinal mucus layer and increase the intestinal permeability of the entrapped drug. The objective of the present study was to develop and characterize polymeric nanoparticulate …
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Interfacial Properties of Environmentally Responsive Polymers
… of NIPAM-Gly copolymer, we also investigated the mucoadhesive properties using SFA and Surface Plasmon Resonance (SPR), and identify key parameters that control the interaction between hydrogen bonding polymers and soluble mucin.
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Bioadhesive Microparticles and Liposomes of Anti-Parkinson Drugs for Nasal Delivery
… study has investigated the potential of powdered mucoadhesive microparticles and liquid liposomes for nasal delivery via Miat® nasal insufflator and nasal spray devices respectively. Optimum mucoadhesive chitosan microparticles were prepared by co-spray drying of chitosan glutamate and ropinirole …
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Proliposome Technology for Protein Delivery
… aim of this work was to develop novel submicron mucoadhesive liposomes entrapping the protein immunoglobulin g (IgG) using the proliposome method. Additionally, this work explored the potential of the generated liposomes for respiratory tract delivery via medical nebulisers and nasal sprays with …
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… of one of the liquid polymers were embedded in mucoadhesive wafers and were evaluated for spatially defined drug delivery to engineered tissues. Lastly, exogenously controlled drug release was demonstrated using a novel gold-coated hydrogel and focused ultrasound. Together, these studies have …
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Development of an Ingestible Fluid Wicking Gastric Electrical Stimulation Platform for Hormone Modulation
… in low size, weight, and power (SWaP) ingestible mucoadhesive and fluid sampling systems.
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Novel polyelectrolyte complexes for oral insulin delivery.
… showed that all polymers exhibited a similar mucoadhesive profile with their corresponding insulin PEC, with thiolated Paa derivatives adsorbing greater than 20% more mucin than Paa. Thiolation of QPaa did not result in a noticeable improvement in its mucoadhesive capacity, indicating that …
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Formulation of novel buccal mucosal drug delivery systems for nicotine replacement therapy (NRT)
… NIC stability and a slower release from a mucoadhesive system suitable for targeted buccal drug delivery. Finally, wafers demonstrated a higher permeation flux (140.5547.55g/cm2/hr) than films (42.315.22g/cm2/hr), and can be considered safe (≥ 70% viable cells).
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Development of a topical epigallocatechin gallate (EGCG) formulation
… agents. Carbopol RTM 974, best known for its mucoadhesive properties, was found to produce the highest viscosity. In the last phase of the study EGCG was incorporated into the anhydrous formulations. The in vitro release characteristics were then evaluated using a Franz-type diffusion cell …
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Development and physical characterisation of polyethylene glycol glycerides-based gel formulations for macromolecule delivery
… range of microstructures of the gels enables the mucoadhesive properties and release profiles of lysozyme from the gels to be controlled. Highly stable disc-shaped nanoparticles were produced from the Gelucire gels using a single-step and solvent-free method without the addition of stabilisers. In …
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Grewia polysaccharide gum as a pharmaceutical excipient
… cosmetics, foods and liquid medications, and as mucoadhesives and controlled release polymeric matrices in solid dosage forms. The physicochemical characterization of candidate excipients forms an essential step towards establishing suitability for pharmaceutical application. For natural gums, …
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