Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 161 for “"mucin"”.
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Mucin and mucin glycans alter behaviorof mucosal pathogens
… mucus model composed of natively purified mucin polymers, the major gel-forming component of mucus. With this system, I can disentangle the effects of mucin from the rest of mucus, such as other proteins and salts. I first explore mucin’s impact on Klebsiella pneumoniae, an often multi-drug …
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Cancer immunotherapy with Mucin-1 and cytokines
Cancer immunotherapy involves the manipulation of the immune response to combat tumour cells. The studies contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, …
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Syntaxin-3 mediates baseline and stimulated mucin secretion
… rates at which airway epithelial cells secrete mucin. The low baseline rate accounts for ciliary clearance, and the high stimulated rate obstructs airways in protection from helminths or in obstructive pulmonary diseases. The exocytosis of mucins occurs via the four-helix SNARE complex. The …
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Vesicle-associated Membrane Proteins in Airway Mucin Secretion
… Despite extensive research on controlling mucin production and hydration, the process of secretion is not yet fully comprehended.</p> <p>Mucin undergoes regulated secretion at two rates: a low baseline rate and a high stimulated rate. Over the past 25 years, our lab has discovered and …
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The regulation of bacterial virulence by mucin glycans
… activity of mucus is enabled mucin, a glycoprotein that forms the mucus gel. Upon sensing the O-glycans displayed mucin, opportunistic pathogens can alter their gene expression, and are less likely to engage in virulence behaviors like biofilm formation and toxin production. …
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Poly(β-Gal-Thr): A New Scalable Synthetic Mucin
… the highly glycosylated PTS domains of secreted mucin proteins.</p>
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Modulation of airway mucin glycosylation by Pseudomonas aeruginosa pyocyanin
… levels of sialyl-Lewisx modifications on airway mucins in a mouse model and in in vitro cell culture. We found PCN to be a potent inducer of sialyl-Lewisx in both mouse airways and in the cultured airway epithelial cells. PCN increases the expression of ST3Gal-IV and C2/4GnT, two enzymes …
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The influence of mucin glycans on microbial virulence and competition
… model of the mucus environment based on mucin glycoproteins, the major structural component of mucus. This in vitro culturing system mimics the natural mucus environment, where mucin polymer domains interact and entangle into a flexible hydrogel, as opposed to 2-dimensional surface …
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Analyzing the Role of Mucin O-Glycans in Regulating Microbial Virulence
… Defects in the production or glycosylation of mucins, the gel-forming component of mucus, are associated with microbial dysbiosis and infection; however, owing to the complexity of mucins, an understanding of the molecular motifs and mechanisms underlying mucins’ protective functions remains …
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An investigation of the role of mucin gels in disease progression and transmission
… serves as a barrier: a mesh network made of mucin polymers that act as a size and biochemical filter, trapping small molecules, including pathogens. When mucus is cleared from the respiratory tract via exhalations such as coughing or sneezing, it can act as a vessel for infectious material …
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The role of mucin in establishment of Escherichia coli in porcine small intestine
Mucin was isolated for incorporation in bacteriological media by reduction and proteolysis of mucous gel from porcine small intestine. Mucin prepared in this study contained (by weight) 37.2% protein, 58.7% carbohydrate (4.6% fucose, 9.4% mannose, 10.7% sialic acid, 13.5% galactose, and 20.5% …
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New insights into molecular recognition of epitopes related to MUC1 human mucin by lectins
… Tn determinant is a convenient cancer biomarker. Mucin-like glycopeptides and glycoproteins, in particular MUC1, incorporate this structure in their sequence. While in normal cells this O-glycosylated protein carries complex oligosaccharides, in cancer cells, MUC1 expression is increased and its …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… predominantly of individual proteins termed mucins. Additionally, underlying epithelial cells produce interferons upon virus detection that promote the establishment of a local antiviral state through autocrine and paracrine signaling. However, despite these protective measures, IAV continues …
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EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege
… which include the EGF module-containing mucin-like hormone receptor (EMR) molecules. In the human, EMR1 has sequential homology with F4/80 and EMR2 has shown immune suppressing function in tumor cells. Thus, we investigate the possible suppressor role of the EMR family in human ocular …
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Mucin expression in normal and diseased states of the stomach : a histochemical and immunohistochemical study
Nine human mucin genes have been described, which express glycoproteins MUCJ,2,3,4 ,5AC,5B,6, 7, and 8 in various tissues. It has been shown that different mucins are expressed in various gastric disease states as compared to the normal. In this study histochemical and immunohistochemical methods …
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