Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"muc2"”.
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SNARE-mediated exocytosis of MUC2 from intestinal goblet cells
… by goblet cells that produce and store MUC2 mucin within secretory granules. Release of mucin occurs constitutively to maintain the barrier and is inducibly when goblet cells sense a threat such as an invading pathogen. Given the immense importance of the mucus layer in maintaining …
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High MUC2 Biosynthesis and Production Augment Pro-Inflammatory Responses in Colonic Goblet Cells
… goblet cells hypersecrete and become depleted of MUC2 mucin, impairing the protective mucus barrier to allow the parasite to contact the colonic epithelium and induce a robust pro-inflammatory cytokine response. While colonic absorptive epithelial and immune cells have been shown to produce …
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The effect of butyrate-supplemented total parenteral nutrition on muc2 mRNA and goblet cell chemotypes in a short bowel syndrome neonatal piglet model
… the small intestine. We also hypothesize that muc2 mRNA abundance will increase in the small intestine with butyrate and SCFA-supplemented TPN infusion, whereas colonic muc2 mRNA abundance will increase in the colon with 60 mM butyrate administration. Methods: Forty-eight hour old piglets …
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Tissue adaptations to colitis influence neoplastic risk through clonal interaction
… Tissue adaptations were described in the *Muc2<sup>KO</sup>* model of colitis, including profound remodelling of the extracellular matrix compartment pre-pathology and during active disease. Upregulation of small-leucine-rich proteoglycans was found to be an early adaptation to colitis, …
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Colonic mucus structure and processing
… partly achieved by creating a dense gel with the MUC2 gel-forming mucin as scaffold. Available MUC2 biochemical and histological data suggest that the mucus is highly structured and organized. Mucus homeostasis is dependent on production, secretion and processing of mucus components. Thus, factors …
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Mucin expression in normal and diseased states of the stomach : a histochemical and immunohistochemical study
… both categories showing expression of MUC2 and 3 predominantly. Early intestinal type adenocarcinomas did not show any mucins in the majority of cases. Advanced intestinal type adenocarcinomas showed immunoreactivity predominantly for MUCJ, 5 and 6, as well as MUC2 in some cases. …
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Αδενοκαρκινώματα στομάχου. Ανοσοέκφραση κερατινών και γλυκοπρωτεϊνών της οικογένειας MUC
… MUC5AC, MUC6) και στην εντερική μετάπλαση (MUC2) και αποτελούν δείκτες προέλευσης/διαφοροποίησης για τα καρκινώματα του γαστρεντερικού σωλήνα και του παγκρέατος/χοληφόρων. Στην παρούσα μελέτη εκτιμήθηκε σε μία σειρά γαστρικών καρκινωμάτων, η έκφραση των ανωτέρω γλυκοπρωτεϊνών καθώς και των …
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A study of morphological, immunohistochemical and histochemical features of ampullary carcinomas
… review and included p53, Ki-67, MUC1, MUC1core, MUC2 and CA 19.9. The data was analyzed by multivariate analysis.
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Delayed access to feed affects broiler small intestinal morphology and intestinal cell ontogeny
… Peptide Transporter 1 (PepT1), and Mucin 2 (Muc2), in response to DAF. The Olfm4 mRNA can clearly identify stem cells in the intestinal crypt, which allows VH and CD to be measured, while Ki-67 marks the proliferating cells. The peptide transporter PepT1 is located on intestinal epithelial …
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Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… mechanism of calcium (Ca2+) coupling mucus (MUC2) secretion in colonic goblet cells in situ, using an ex-vivo 3D model native human colonic crypt model system. Immunohistochemistry revealed the presence of cholinergic neurons in close proximity to the basal membrane of the crypts, where the …
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The biochemical and molecular characterisation of respiratory mucins in TB
… respiratory mucins (MUC5AC and MUC5B) and MUC2 has been investigated in chronic airway diseases as it is the mucin glycoprotein that confers upon mucus its biological, rheological and physicochemical properties. Within South Africa, specifically the Western Cape, TB has wreaked havoc …
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The biochemical analysis of mucus and mucins in respiratory diseases with a focus on tuberculosis
… chloride. Identification of MUC5AC, MUC5B, MUC2 and MUC7 were determined by western blotting and confirmed by immunohistochemistry. Western blot data proved the dominance of MUC5AC and MUC5B mucins in airway mucus. In comparison to the non-TB group, a higher secretion of MUC5AC than MUC5B in …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
… ileal villus height: crypt depth ratio, ileal MUC2 mRNA abundance, proximal colon AMPK mRNA abundance, and occludin mRNA abundance in the proximal and distal colon regions. When comparing fructan vs. cellulose treatments using contrasts, fructans resulted in a greater (p<0.05) transmural …
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Outlining a balance-point model of homeostasis in the small intestine of broiler chickens
… a marker gene for enterocytes and Mucin-2 (Muc2) a marker gene for goblet cells compared to non-injected control embryos. Also, on e20 the embryos in ovo fed saline only had numerically increased PepT1 and Muc2 compared to non-injected control embryos. The difference in responses between the …
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… (Ile105Val) and GCLC repeats, 4) mucin genes (MUC2 and MUC5B). Pulmonary disease progression and survival in patients with chronic Burkholderia cepacia complex (BCC) infection were also investigated controlling for genomovar and RAPD type of the organism. BCC infection was associated with more …
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Local Inflammatory Responses in Pseudomyxoma Peritonei
… is a peritoneal neoplastic disease arising from MUC2 producing goblet cells of the appendix and is characterized by the accumulation of massive amounts of mucinous ascites. Little is known about the tumor microenvironment that might give insight into the local inflammatory processes in the …
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Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease
… to IBD susceptibility, tagging SNPs across the MUC2, MUC3A and MUC19 genes were genotyped in the Edinburgh IBD cohort and examined for a link with IBD, CD and UC susceptibility, but associations were not found. In view of the strong association with CD susceptibility of a SNP near the MUC19 …
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Intestinal Adaptation in Pediatric Short Bowel Syndrome : Controlled Assessment of Duodenal Mucosa after Extensive Bowel Resection
… mRNA expression of Claudin 1 (CLDN1), Mucin 2 (MUC2) and Glucose transporter, GLUT1 (SLC2A1) and decreased expression of NLR family CARD containing 4 (NLRC4) (P<0.005 for all). Weaned-off patients showed increased histologic inflammation of the lamina propria and elevated Tumor necrosis factor …
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Investigating the potential utilisation of black soldier fly (Hermetia illucens) as an alternative protein source in tilapia and carp feed
… ocln), and mucosal immunity markers (IgM, pIgR, muc2) were unaffected, while β-defensin 1, pcna, and hsp70 were downregulated. While microbiota diversity remained stable across the diets, BSF frass reduced Proteobacteria and Campylobacterota, and increased Spirochaetota and Brevinema. Growth …
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Exploring the gut microbiome: metaproteome analysis of HIV-exposed uninfected infants
… Infant proteins revealed alteration in MUC2 mucin gut barrier and inflammation in HEU infants, differences in immune proteins from breastmilk proteins, and bacterial proteins revealed Ruminococcus gnavus as an HEU associated species. Conclusion: The altered gut barrier paired with gut …
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