Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"muc2"”.
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SNARE-mediated exocytosis of MUC2 from intestinal goblet cells
… by goblet cells that produce and store MUC2 mucin within secretory granules. Release of mucin occurs constitutively to maintain the barrier and is inducibly when goblet cells sense a threat such as an invading pathogen. Given the immense importance of the mucus layer in maintaining …
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High MUC2 Biosynthesis and Production Augment Pro-Inflammatory Responses in Colonic Goblet Cells
… goblet cells hypersecrete and become depleted of MUC2 mucin, impairing the protective mucus barrier to allow the parasite to contact the colonic epithelium and induce a robust pro-inflammatory cytokine response. While colonic absorptive epithelial and immune cells have been shown to produce …
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The effect of butyrate-supplemented total parenteral nutrition on muc2 mRNA and goblet cell chemotypes in a short bowel syndrome neonatal piglet model
… the small intestine. We also hypothesize that muc2 mRNA abundance will increase in the small intestine with butyrate and SCFA-supplemented TPN infusion, whereas colonic muc2 mRNA abundance will increase in the colon with 60 mM butyrate administration. Methods: Forty-eight hour old piglets …
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Tissue adaptations to colitis influence neoplastic risk through clonal interaction
… Tissue adaptations were described in the *Muc2<sup>KO</sup>* model of colitis, including profound remodelling of the extracellular matrix compartment pre-pathology and during active disease. Upregulation of small-leucine-rich proteoglycans was found to be an early adaptation to colitis, …
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Mucin expression in normal and diseased states of the stomach : a histochemical and immunohistochemical study
… both categories showing expression of MUC2 and 3 predominantly. Early intestinal type adenocarcinomas did not show any mucins in the majority of cases. Advanced intestinal type adenocarcinomas showed immunoreactivity predominantly for MUCJ, 5 and 6, as well as MUC2 in some cases. …
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A study of morphological, immunohistochemical and histochemical features of ampullary carcinomas
… review and included p53, Ki-67, MUC1, MUC1core, MUC2 and CA 19.9. The data was analyzed by multivariate analysis.
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Delayed access to feed affects broiler small intestinal morphology and intestinal cell ontogeny
… Peptide Transporter 1 (PepT1), and Mucin 2 (Muc2), in response to DAF. The Olfm4 mRNA can clearly identify stem cells in the intestinal crypt, which allows VH and CD to be measured, while Ki-67 marks the proliferating cells. The peptide transporter PepT1 is located on intestinal epithelial …
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Mechanism and role of calcium in excitation-mucus secretion coupling in human colonic epithelium
… mechanism of calcium (Ca2+) coupling mucus (MUC2) secretion in colonic goblet cells in situ, using an ex-vivo 3D model native human colonic crypt model system. Immunohistochemistry revealed the presence of cholinergic neurons in close proximity to the basal membrane of the crypts, where the …
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The biochemical and molecular characterisation of respiratory mucins in TB
… respiratory mucins (MUC5AC and MUC5B) and MUC2 has been investigated in chronic airway diseases as it is the mucin glycoprotein that confers upon mucus its biological, rheological and physicochemical properties. Within South Africa, specifically the Western Cape, TB has wreaked havoc …
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The biochemical analysis of mucus and mucins in respiratory diseases with a focus on tuberculosis
… chloride. Identification of MUC5AC, MUC5B, MUC2 and MUC7 were determined by western blotting and confirmed by immunohistochemistry. Western blot data proved the dominance of MUC5AC and MUC5B mucins in airway mucus. In comparison to the non-TB group, a higher secretion of MUC5AC than MUC5B in …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
… ileal villus height: crypt depth ratio, ileal MUC2 mRNA abundance, proximal colon AMPK mRNA abundance, and occludin mRNA abundance in the proximal and distal colon regions. When comparing fructan vs. cellulose treatments using contrasts, fructans resulted in a greater (p<0.05) transmural …
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Outlining a balance-point model of homeostasis in the small intestine of broiler chickens
… a marker gene for enterocytes and Mucin-2 (Muc2) a marker gene for goblet cells compared to non-injected control embryos. Also, on e20 the embryos in ovo fed saline only had numerically increased PepT1 and Muc2 compared to non-injected control embryos. The difference in responses between the …
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… (Ile105Val) and GCLC repeats, 4) mucin genes (MUC2 and MUC5B). Pulmonary disease progression and survival in patients with chronic Burkholderia cepacia complex (BCC) infection were also investigated controlling for genomovar and RAPD type of the organism. BCC infection was associated with more …
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Local Inflammatory Responses in Pseudomyxoma Peritonei
… is a peritoneal neoplastic disease arising from MUC2 producing goblet cells of the appendix and is characterized by the accumulation of massive amounts of mucinous ascites. Little is known about the tumor microenvironment that might give insight into the local inflammatory processes in the …
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Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease
… to IBD susceptibility, tagging SNPs across the MUC2, MUC3A and MUC19 genes were genotyped in the Edinburgh IBD cohort and examined for a link with IBD, CD and UC susceptibility, but associations were not found. In view of the strong association with CD susceptibility of a SNP near the MUC19 …
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Investigating the potential utilisation of black soldier fly (Hermetia illucens) as an alternative protein source in tilapia and carp feed
… ocln), and mucosal immunity markers (IgM, pIgR, muc2) were unaffected, while β-defensin 1, pcna, and hsp70 were downregulated. While microbiota diversity remained stable across the diets, BSF frass reduced Proteobacteria and Campylobacterota, and increased Spirochaetota and Brevinema. Growth …
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Exploring the gut microbiome: metaproteome analysis of HIV-exposed uninfected infants
… Infant proteins revealed alteration in MUC2 mucin gut barrier and inflammation in HEU infants, differences in immune proteins from breastmilk proteins, and bacterial proteins revealed Ruminococcus gnavus as an HEU associated species. Conclusion: The altered gut barrier paired with gut …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… markers of IEC populationages (Lg5, E-cadherin, Muc2 and Tff3), autophagy (P62), ER stress response (spliced Xbp1) and apoptosis (cleaved caspase 3 protein), as well as EdU incorporation proliferation assays were then performed. Our results indicate that the loss of Ifng and Socs1 is not …
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INTERACTIVE EFFECT OF DIETARY FIBRE AND IMMUNE CHALLENGE ON THREONINE REQUIREMENT AND INTESTINAL BARRIER FUNCTION IN GROWING PIGS
… goblet cell numbers and tended to increase MUC2 gene expression in the ileum. The non-additive effect of systemic ISS and HF on PD is consistent with the LPS induced loss of barrier function in the LF fed pigs which contributed to increased Thr requirement for PD. Indeed, no loss of barrier …
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The Influence of Necrotic Enteritis, Environmental Factors, and Genetics on Intestinal Development Pathways and Disease Occurrence in Broiler Chickens
… in expression of secretory goblet cell marker Muc2. The findings of these studies give multiple perspectives into poultry production and how major factors in management including nutrition, environment, and genetics can be used to increase efficiency while preventing disease.
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