Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"mtor pathway"”.
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Regulation of peripheral nerve regeneration by the mTOR pathway
… of the mammalian target of rapamycin: mTOR) pathway. We find that PNS dorsal root ganglia neurons: DRGs) activate mTOR following damage, and that this activity contributes to enhance axonal growth capacity following injury. Furthermore, upregulation of mTOR activity by deletion of …
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Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis
Background The PI3K/AKT/mTOR pathway is an intracellular signaling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Aim of our …
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T Cell Intrinsic BCAP Links IL1R to the PI3K-mTOR Pathway and Regulates Pathogenic Th17 Differentiation
… determined a role for BCAP in the TLR signaling pathway in myeloid cells. Due to the shared use of TIR domains by TLR and IL1R signaling pathways, I hypothesized that BCAP would also be involved in signaling downstream of the IL1 family of receptors. The IL1 cytokine family has been shown to play …
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Characterization of Notch1 and Pi3K-Pten-Akt/Mtor Pathway Interaction In Head and Neck Squamous Cell Carcinoma
… mutations are sensitive to PI3K and dual PI3K/mTOR inhibitors, leading us to investigate the interaction of these pathways in HNSCC. The NOTCH pathway plays key roles in cell proliferation, differentiation, and apoptosis. With inactivating mutations in 18% of 510 HNSCC patient samples, …
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying PI3K/AKT/mTOR pathway …
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The mechanism of ovarian cancer chemoresistance
… cancer stem cells (CSC), as well as the PI3K/Akt/mTOR signalling pathway in OC chemoresistance, and provides a range of potential candidate chemoresistant biomarkers with proteomic technologies. The aims of this study were to: 1) compare the expression differences of EMT, CSC and PI3K/Akt/mTOR …
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The PI3-Kinase/TSC Pathway: A Role in Neural and Renal Development and Pathology
… product negatively regulates the PI3K/AKT pathway through counteracting the kinase function of PI3-Kinase. Loss of function of PTEN results in overactivation of AKT and in turn activates multiple AKT downstream pathways. One AKT substrate is the TSC1/2 protein complex, which controls …
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
… UL tumors to the over-activation of the PI3K/AKT-mTOR pathway. This work establishes, for the first time, a comprehensive molecular pathway starting from known environmental estrogen risk factors leading to activation of the most crucial cell proliferation pathway in UL. We identified the most …
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mTOR Signaling in Cellular Growth and Skeletal Muscle Maturation
A Serine/Threonine kinase, mTOR, is a cellular target of rapamycin and plays a role in cellular growth and proliferation by regulating translation through the phosphorylation of 4E-BP1 and S6K. Here, I investigated the function of mTOR for the activation of newly found S6K1 homologue, S6K2, and for …
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Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
… target of rapamycin (PI3K/mTOR) signaling pathway can be used to predict patient outcome in cohorts containing patients with various subtypes of soft tissue sarcoma. Furthermore, we have previously shown that high levels of phosphorylated AKT correlate to poorer …
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The Contribution of Spleen Tyrosine Kinase to the Pathobiology of Alzheimer’s Disease
… of tau via the mammalian target of rapamycin (mTOR) pathway <i>in vitro</i> and <i>in vivo</i>. We investigated SYK activation in different age-groups of A-beta and tau overexpressing mice, as well as human AD specimens. We characterized the activation of SYK in relation to AD pathological …
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Diabetes and Obesity Induce Transcriptomic and Metabolomic Changes Enhancing Pancreatic Cancer Aggressiveness
… and diabetes, namely via activation of the AKT/mTOR pathway. Metformin treatment decreased the obesity-induced and diabetes-induced AKT/mTOR pathway activation and tumor growth. Adipokine profile array showed an induced secretion of several adipokines in the obese and diabetic mice compared with …
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The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… activity via the mammalian target of rapamycin (mTOR) pathway in prostate cancer cells. Telomerase–the enzyme responsible for immortalizing cells through telomeric repeats addition–is de-repressed early in an aspiring cancer cell. We hypothesized that perillyl alcohol regulates hTERT (human …
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Mechanisms of Post-hemorrhagic Hydrocephalus after Germinal Matrix Hemorrhage
… receptors, leading to subsequent mTOR activation and extracellular matrix protein proliferation, which possibly obstruct the cerebroventricular system. Blood clots may directly impair cerebrospinal fluid circulation and absorption. PPARγ stimulation enhances micgroglial/macrophage …
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Evaluation of amino acid transport and protein metabolism in the mammary gland of dairy cattle
… state of proteins associated with the mTOR pathway was impacted by both EAA treatments. Changes in the udder proteome suggest negative feedback on mTOR pathway activation when milk protein yield was increased by the EAA groups separately but when supplemented together, negative feedback …
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Lysosomal nutrients and the mTORC1 pathway
… of activation of the master growth regulator mTORC1 (mechanistic target of rapamycin (mTOR) complex 1), and is often deregulated in common diseases, such as cancer. Given the critical role of lysosomes in maintaining cellular homeostasis, a better understanding of lysosomal function and …
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Regulation and role of the LKB1-AMPK pathway
… ratios. Once active, AMPK activates catabolic pathways and inhibits anabolic pathways to restore cellular energy homeostasis. AMPK activity can be increased by phosphorylation of Thr172, a conserved residue in the activation loop of the kinase domain, by either LKB1 or CaMKKß. Increases in …
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A Phase I Dose-Escalation Study of The Braf Inhibitor Vemurafenib In Combination With The Mtor Inhibitor Everolimus In Subjects With Advanced Cancer
… other malignancies. The RAS/RAF/MEK/ERK (MAPK) pathway is critical to cell proliferation in many human cancers. The mTOR inhibitors are well known to exert profound anticancer effects across malignancies through inhibition of the PTEN/PI3K/AKT/mTOR (mTOR) pathway. We hypothesize that the …
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Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function
… regulate the mammalian target of rapamycin (mTOR) in both naïve and activated T cells. mTOR is a critical regulator of cell growth and metabolism. By virtue of its kinase ability, mTOR has been shown to initiate signaling in response to a variety of extracellular signals including cytokines, …
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
… of the phosphoinositide 3-kinase (PI3K) pathway by transgenic knockout of phosphatase and tensin homolog (PTEN) promotes survival and regeneration of murine RGC axons in an optic nerve crush (ONC) model. However, translation issues are yet to be addressed. PI3K converts …
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