Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 262 for “"mtDNA"”.
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The phylogenetic affinities of Crenichthys and Empetrichthys using mtDna
Crenichthys (Springfish) and Empetrichthys (Poolfish) are two relictual genera of cyprinodontiform fishes that are restricted to the state of Nevada. Of five families proposed, three, Cyprinodontidae, Goodeidae, and Empetrichthyidae, are still under consideration. The Goodeidae, fishes endemic to …
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Safeguarding the mitochondrial genome: identifying components of the mtDNA repair machinery
Mechanisms that safeguard mitochondrial DNA (mtDNA) are crucial for limiting the accumulation of mutations associated with mitochondrial dysfunction and age-related diseases. Despite this, the pathways responsible for repairing double-strand breaks (DSBs) in animal mitochondria remain poorly …
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Optimisation and validation of tools for in situ visualisation of heteroplasmic mtDNA variants.
… in our cells; it holds its own genome (mtDNA). Eukaryotic cells often contain many hundreds to thousands of copies of mtDNA. When a mutation occurs in one or more of these copies, this results in a mixture of mutant and wildtype mtDNA, known as heteroplasmy. Developmental and …
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Genetic variation among Zulu sheep sub-populations of South Africa assessed by microsatellites and mitochondrial DNA (mtDNA)
… A lineage had a frequency of 7%. The analysis of mtDNA showed a high level of genetic diversity among Zulu sheep. The molecular information obtained in the present study will serve as a guideline for management and breeding strategies (reducing inbreeding and crossbreeding) for better utilisation …
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Impact of mtDNA Signature on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Progression and Cardiometabolic Outcomes in Mice
… contributors, variation in mitochondrial DNA (mtDNA) has been linked to differences in bioenergetic function, oxidative stress, and disease susceptibility. Given mitochondria’s central role in metabolism and their unique maternal genomes, mtDNA haplotypes, shaped by evolutionary adaptation, may …
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No hea te kiore : MtDNA variation in Rattus exulans : a model for human colonisation and contact in prehistoric Polynesia
Phylogenetic reconstruction, originally developed for biological systematics, is a tool which is increasingly being used for anthropological studies addressing the problems of population origins and settlement patterns. Given the nature of the phylogenetic model, it is expected that phylogenetic …
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How to Mend a Broken Mitochondrial Genome: Mitochondrial Recombination And Its Applications
… rely on genes encoded within their own genome (mtDNA) in addition to those in the nucleus. mtDNA mutations are linked to mitochondrial and age-related diseases. Therefore, safeguarding mechanisms are crucial to limit mtDNA mutations and curtail ageing and disease. Yet, pathways that repair …
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Investigating the Regulation of Mitochondrial DNA Dynamics with a Drosophila Model
The maternally inherited mitochondrial DNA (mtDNA) is a multi-copy genome that encodes several mitochondrial proteins essential for energy production. Heteroplasmy, the state of possessing multiple variants of mtDNA, is very common in humans. The levels of these mtDNA variants are subject to …
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Mitochondrial DNA replication in pre-implantation embryonic development
All eukaryotic cells possess mitochondrial DNA (mtDNA), which is maternally inherited through the oocyte, its replication being regulated by nuclear-encoded replication factors. It was hypothesised that mtDNA replication is highly regulated in oocytes, pre-implantation embryos and embryonic stem …
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Modelling and correction of retinal pathologies caused by mitochondrial DNA mutations via genetic engineering
… energy production role, contain their own DNA (mtDNA), which is susceptible to mutations. These mutations underlie primary mitochondrial diseases, often affecting high energy-demand tissues such as the retina, brain, heart, and skeletal muscle. Consequently, they constitute a common cause of …
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Theoretical and Statistical Approaches to Understand Human Mitochondrial DNA Heteroplasmy Inheritance
Mitochondrial DNA (mtDNA) mutations have been widely observed to cause a variety of human diseases, especially late-onset neurodegenerative disorders. The prevalence of mitochondrial diseases caused by mtDNA mutation is approximately 1 in 5,000 of the population. There is no effective way to treat …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… Mutations in or loss of mitochondrial DNA (mtDNA) can cause neurodegeneration and has been linked to Parkinson‟s disease. However, the pathological consequences of mtDNA loss in neurons are very poorly understood.<br/><br/>We have used the fruitfly, Drosophila melanogaster, to study how loss …
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Transcription Regulates Biased Mitochondrial DNA Inheritance
Maintaining mitochondrial DNA (mtDNA) is essential in eukaryotes for cellular respiration and ATP production by oxidative phosphorylation. Respiration is the preferred method for creating mitochondrial membrane potential, which is important for the import of nuclearly encoded proteins into the …
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