Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"mouse spermatocytes"”.
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Genetic Analysis of Crossover Defective Mouse Spermatocytes Reveals Discrete Crossover Precursor Intermediates
… result in aneuploidy. In humans, 1-8% of spermatocytes and 10-30% of oocytes are aneuploid, contributing to ~ 5% of clinically detected pregnancies with aneuploid embryos. With few exceptions, human aneuploidies are lethal; thus, aneuploidy is the leading genetic cause of infertility and …
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Higher Order Chromosome Organization and Recombination Dynamics of Meiotic Prophase I In Mouse Spermatocytes
… a novel and robust system to synchronize mouse spermatogenesis in F1 hybrid mice using the inhibitor WIN 18,446. My synchronizationprotocol allows the isolation of cells at specific stages of meiotic prophase I by flow cytometry, allowing me to analyze recombination outcomes at two meiotic …
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Epic Search for the Perfect Partner: MutSgamma Promotes Efficient Meiotic Recombination and Homolog Pairing in Mouse Spermatocytes
… between more than two chromosomes). As such, spermatocytes from these mutants apoptose, and these mice are infertile. It has also been shown, both in budding yeast and in mouse, that mutations to the ATPase domain of MSH5 have similar defects. These mutants do not form crossovers and have …