Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"mouse retina"”.
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Electrical synapses: cellular morphology and identification of connexins in the mouse retina
Das Ziel meiner Dissertation war die Zahl der deplatzierten Amakrinzelltypen (DAZ), die Identifikation der Cx45-exprimierenden Amakrinzellen (AZ) und Cx30.2-exprimierenden Ganglienzellen (GZ) zu erforschen. Außerdem wurde die Lokalisation von Cx57 in den Horizontalzellen (HZ) untersucht. Gefunden …
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A connectomic analysis of the directional selectivity circuit in the mouse retina
… of how direction selectivity (DS) arises in the mouse retina. DS has long been observed in retinal ganglion cells, and more recently confirmed in the starburst amacrine cell. Upstream retinal bipolar cells, however, have been shown to lac, indicating that the mechanism that gives rise to DS lies …
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Microglial activation in the harlequin mouse retina as a mechanism for early retinal degeneration
The prevalence of aging-related retinal degenerative disorders is rising amongst human populations and the origins and early mechanisms of retinal disease remain poorly understood. A model of premature aging, the harlequin mouse, was used to test the hypothesis that parainflammation, a response to …
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MELANOPSIN AND PACAP IN INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS REGULATE THE DEVELOPMENT OF RETINOFUGAL PROJECTIONS IN MICE
In the retina, a small subset of retinal ganglion cells are intrinsically photo-sensitive (ipRGCs) and express the photopigment melanopsin and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP). These cells project to brain nuclei to mediate a variety of visual behaviors …
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
… synaptic processes. In studies of rabbit retina, we found SAP102 and Chapsyn110 selectively localized in the tips of B-type horizontal cell processes where they contact cone and rod photoreceptors. We further identified some known SAP102 binding partners, kainate receptor GluR6/7 and …
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Controlled Migration of Retinal Progenitor Cells Within Electro-Chemotactic Fields
<p>Vision loss in retinal degenerative diseases is overwhelmingly attributed to damage and death of retinal photoreceptor cells. Studies in mouse retina have suggested that transplantation of isolated post-natal or stem cell-derived retinal progenitor cells (RPCs) to replace apoptotic or damaged …
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A Modular Computational Framework for Integrating Motion and Chromatic Representations in Mice Retina
… and chromatic response representations in the mouse retina. Although motion and color processing have been extensively studied, they are typically characterized using different experimental paradigms and incompatible representational forms. Motion sensitivity is described through spatiotemporal …
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Premature vascular senescence during diabetic retinopathy
… to investigate the senescence profile of human retinal microvascular endothelial cells (HRMECs), to elucidate how this is affected by the diabetic milieu. <br/><br/>HRMECs undergo replicative senescence in vitro and they acquire gene and protein expression profiles that are characteristic of a …
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Splicing The Clock Is Timeless: From Fruit Fly Behavior To Mammalian Retinal Degeneration
… for these splicing factors. Our studies in the mouse model of retinitis pigmentosa (RP) support this hypothesis and demonstrate that a Prpf8 knockin mutation lengthens circadian wheel-running behavior and dampens the diurnal rhythm in select transcripts of the mouse retina. We explore the …
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Characterization of Retinal Defects in Engrailed-2 Knockout (En2-/-) Mice, a Model for Autism Spectrum Disorders (ASD)
… suggested that, at cellular level, the retina of En2-/- mice showed alterations in the number of specific cell subtypes compared with the retina of WT littermates. More importantly, an increasing number of studies published in the past years indicated that difficulties in sensory …
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X-LINKED RETINOSCHISIS ELECTROPHYSIOLOGY, MOLECULAR GENETICS AND TREATMENT
… (XLRS) is a congenital progressive inherited retinal disease that affects the entire retina and is one of the more common causes of vision loss from retinal degeneration affecting young men,. The progression is variable but seems to be relatively stationary in the ages 6 to 25 years. Patients …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
Damage to the neural retina or optic nerve results in irreversible blindness because the mammalian retina cannot regenerate. For stem cell therapies to regenerate a functional retina, multiple challenges must be overcome. These include identification of stem cell sources, targeted differentiation …
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TOWARDS RETINA REGENERATION: THE EPIGENETIC BASIS OF NEURONAL AND AXON GUIDANCE GENE REGULATION
… the population yearly, the need for regenerative retina and optic nerve therapy is self-evident. Increasing evidence suggests that Müller glia are potential stem cells in the adult mammalian retina but have a limited potential to differentiate into retinal ganglion cell (RGC). Understanding the …
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Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa
… However, despite the need for treatment, mouse models with mutations in the alpha subunit of PDE6 have not been characterized beyond 1 month of age or used to test the pre-clinical efficacy of potential therapies for human patients with RP caused by mutations in PDE6A. We first proposed to …
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Towards structural characterisation of ciliary rootlets, ciliary caps and intraflagellar transport
… and ultrastructure. Tomograms of purified mouse photoreceptor cell rootlets showed a longitudinal periodicity with an amorphous striation and three confined striations each 81.3 nm. Subtomogram averaging showed the absence of lateral regularity in both the filaments and confined striations. …