Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mouse pituitary"”.
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DELETION OF THE Foxo1 GENE IN MOUSE PITUITARY GLAND AND THE EFFECTS ON SOMATOTROPE DIFFERENTIATION AND FUNCTION
Various mouse models have allowed for identification of several transcription factors that are necessary for pituitary development. Lesions in the transcription factor genes result in pituitary hormone deficiency. Hormone deficiencies occur in approximately one in 4000 live births. Pituitary …
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The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes
… and explored the mechanism involved in the mouse pituitary gonadotrope LβT2 cell line by dexamethasone (Dex), GnRH and both together.
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Somatic cell gene therapy for diabetes mellitus: engineering a surrogate B-cell
… β-cells. Initial studies were conducted using mouse pituitary AtT20 cells as a model, since these cells possess an endogenous complement of enzymes capable of processing proinsulin to mature insulin. Glucose sensitive insulin secretion was conferred to these cells by transfection with plasmids …
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Ion channels and electrical excitability in native murine anterior pituitary corticotrophs
As a central component of the hypothalamic-pituitary-adrenal (HPA) axis, the anterior pituitary corticotrophs play an important role in the regulation of HPA axis function and the neuroendocrine response to stress. Pituitary corticotrophs integrate stress-induced stimulatory signals (CRH and AVP) …
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The regulation of the luteinizing hormone (LH) and the follicle stimulating hormone (FSH) by glucocorticoids and progestins
… all hormones involved in the hypothalamic-pituitary-ovarian (HPO) axis and key regulators of E2 synthesis and release. This thesis analyzed the serum concentrations of E2, LH, FSH, and GnRH in women randomized to DMPA-IM (n = 100) or NET-EN (n = 93) in a subpopulation of the WHICH cohort. …
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Characterizing neural tissues with mass spectrometry imaging via enhanced computational approaches
Neuropeptides affect the activity of the myriad of neuronal circuits in the brain. They are under tight spatial and chemical control and the dynamics of their release and catabolism directly modify neuronal network activity. Understanding neuropeptide functioning requires approaches to determine …