Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"mouse modeling"”.
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
… we genetically engineered MMRD+PPD and MMRD-only mouse models that faithfully recapitulate the tumor spectrum and genomic characteristics of each human RRD subgroup. All mouse models robustly developed brain tumors displaying phenotypic variation. Using a trans-species approach, we elucidated a …
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Exploring the role of Rapgef6 in neuropsychiatric disorders
… RAPGEF6 and RAPGEF2. Behavioral analysis of a mouse modeling Rapgef6 deletion determined that amygdala function was the most impaired behavioral domain as measured by reduced fear conditioning and anxiolysis. More disseminated behavioral functions such as startle and prepulse inhibition were …
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Dissecting the Role of ATRX in Soft Tissue Sarcoma Development and Therapeutic Response
… poorly understood. Here, we developed a primary mouse model of soft tissue sarcoma and studied the effect of Atrx deletion on tumor development and therapeutic response. Our findings demonstrate that Atrx deletion regulates tumor development and increases sarcoma sensitivity to radiation therapy. …
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Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
… its inherent nature in both patients and mouse models. Studies investigating the mechanisms by which skeletal muscle weakness arises in OI are limited, despite the large prevalence. My research sought to better understand OI muscle weakness primarily through the investigation of …
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC
… The inability to model amplification in the mouse has contributed significantly to our limited mechanistic understanding of how gene amplification occurs in tumors. Using a yeast endonuclease, -Scel, and an allele that contains target sites for this enzyme engineered telomeric to mutant Egfr …