Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1583 for “"mouse model"”.
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Functional Study of Hemogen Knockout Mouse Model
<p>Mouse Hemogen (Hemgn) is regarded as a homologue of human Erythroid Differentiation Associated Gene (EDAG). EDAG overexpression has been postulated for association with some leukemia cases. Meanwhile, Hemgn has been found to contribute to Hoxb4 mediated hematopoietic stem cell expansion. Based …
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Tumor Associated Macrophages in a MaFIA Mouse Model
… To investigate the role of macrophages we used a mouse model known as MaFIA (Macrophage Fas Induced Apoptosis) mice that allows for the selective deletion of macrophages. Mice were given melanoma cells at various stages of depletion. Tumor mass was measured and organs were processed for flow …
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Brain regeneration in a hypoxic-ischemic mouse model
… late phage after HI insult. Compared to normal mouse brain, we verified increasing of newly dividing cells in early phase after HI in the area of SVZ, SGS and SC. Furthermore, neural stem cells which are regulated by sonic hedgehog signaling were also significantly increased in neurogenic niche …
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A mouse model for studying gastrointestinal microbial ecology
… are hindered by the lack of a suitable model system. This thesis characterizes and uses a defined flora mouse model to study interactions between exogenous bacteria and the GI microflora. The first part of the thesis characterizes a defined flora mouse model consisting of immunodeficient …
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Construction of a mouse model of colon cancer
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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A Novel Mouse Model of Asthma Induced by Cockroach
… is an important inhalant allergen and can make a mouse asthma model. However, mechanism underlying the CR-induced mouse model of asthma is not clear and the role of endotoxin contaminated in CR allergen remains controversial. Therefore, we evaluated the role of endotoxin and toll like receptor-4 …
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Partial Molecular and Biochemical Characterization of a Sandhoff Mouse Model
… will be needed to further characterize SD in mouse models and in humans.
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Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
… in this hyperexcitability. Removal of tau in AD models overexpressing amyloid-beta (Abeta) or non-AD models of epilepsy decreases hyperexcitability and normalizes the excitation/inhibition imbalance. The exact mechanism by which tau produces hyperexcitability remains to be determined, but recent …
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Early Mediators of Cutaneous Ischemia Reperfusion Injury: A Mouse Model
… incidence of ischemia reperfusion injury.A mouse model of cyclic ischemia reperfusion was employed to examine the initiation events in the pathology of chronic wounds. Mice were subjected to eight hours of magnetic skin compression via four cycles of two-hours ischemia and thirty minutes of …
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A mouse model for the pathogenesis of immunodeficiency virus infection
… of activated CD4+ T cell killing in a virus-free mouse model. Immunodeficiency viruses are highly selective for activated/memory and regulatory CD4+ T cells due to restricted expression of CCR5, the co-receptor for HIV and SIV, or CD134 (OX40, TNFRSF4), the cellular receptor for FIV. Activated …
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A transgenic mouse model of hereditary motor and sensory neuropathy
… recombination in ES cells, we have generated a mouse containing a nonsense mutation in the intracellular portion of PO (Q215X) that, in the heterozygous state, is associated with CH neuropathy in humans. This mutation is predicted to encode a truncated PO protein, lacking part of the cytoplasmic …
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Understanding The Visual And Auditory Defect In Ush2a Mouse Model
… hearing and visual impairments, a knock in (KI) mouse model (Ush2adelG/delG) was developed using one of the most prevalent human mutations of USH2A, 2299delG. While other models for Ush2a exist, no other KI model has been able to successfully mimic the genetic mutations found in humans. This …
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Investigating pathological mechanisms in the Thy1-hTDP43 ALS mouse model
… in SG composition and morphology observed in ALS models. SGs in ALS are further seen to colocalise with ALS-associated proteins in patient tissues, hinting at a causative role in disease pathogenesis. SGs have only been investigated in ALS using an external stressor. As SGs are dynamic structures, …
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PHENOTYPIC AND MOLECULAR CHARACTERIZATION OF A NOVEL P63ALPHA;KO MOUSE MODEL
… stratification. Here we describe a new p63α-/- mouse model in which we delete exon 13 leading to the expression of the p63β isoform. Newborn p63α-/- mice die soon after birth and are characterised by cleft palate and digit malformations but exhibit normal skin. Our study indicates that p63α and …
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Effect of Coconut Oil on Ulcerative Colitis in the Mouse Model
… (DSS) for 5 and 29 days in the acute and chronic models, respectively. Coconut oil treatment was given via food containing 5% coconut oil to three diseased groups in three different regimens: one, preventive group receiving treatment prior to disease induction (14 d in acute; 28 d in chronic); …
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Anti-Cancer Effects Of Garcinol In Pancreatic Cancer Transgenic Mouse Model
… effects of dietary Garcinol in a transgenic mouse model of Pancreatic Cancer (PaCa). This model is considered to be the animal model which best mimics development of human PaCa. Based on <em>invitro</em> data from our lab we hypothesized that Dietary Garcinol treatment will slow down the …
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Pharmacological Intervention Reduces Hippocampal Hyperactivity in a Mouse Model of Psychosis
… molecular and behavioral characteristics of a model in animals putatively parallel to hippocampal hyperactivity in human schizophrenia brain. A reverse-translational mouse model of psychosis has been developed based on subchronic chemogenetic inhibition of dentate gyrus (DG) during adolescence …
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DISRUPTION OF THE HIPPOCAMPAL GABAERGIC SYSTEM IN THE Fgf14 ̶ / ̶ MOUSE MODEL
… schizophrenia. Although the neurodevelopmental model theory is fully appreciated, it is not well understood. So far, our studies suggest that Fgf14-/-exhibits some of the aspects of schizophrenia. Thus, to provide a better understanding of putative developmental changes in Fgf14-/-, I quantified …
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CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL
… bind DISC1 in a recombinant system and native mouse brain tissue. Disruption of this binding might be involved in the alterations of adult neurogenesis in Fgf14−/− mice. Another possible mechanism is the changes in the axon initial segment (AIS) structure; the changes themselves may result in …
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Characterization of a novel mouse model and vaccines for pulmonary pathogens
… begins with a comprehensive review of the animal models and comparative pathology of three main etiologies of viral pneumonia, including SARS-CoV-2. There are several established transgenic mouse models for COVID-19, but due to differences in receptor distribution and expression levels, these …
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