Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"mouse genomes"”.
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The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis
… the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory …
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Bioinformatics study of mammalian MRNA polydenylation
… of the complete sequence of human and mouse genomes, together with their gene expression data provides valuable resources to study mRNA polyadenylation on a system level. This dissertation addresses the following issues of mammalian mRNA polyadenylation through bioinformatics …
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Discovery of the novel mouFSnrp gene and the characterisation of its in situ expression profile during mouse neurogenesis
… (NRPs), was predicted across the rat, human and mouse genomes by one of my supervisors, Dr. Sieg. Synthetic forms of these proteins have been previously shown to act as potent neuronal chemoattractants and have a major role in neural regeneration. In light of these properties, these peptides are …
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Functional large non-coding RNAs in mammals
… -3,500 transcriptional units in the human and mouse genomes that produce multi-exonic RNAs that lack any coding potential. We termed these large intergenic non-coding RNAs (lincRNAs). Importantly, these lincRNAs exhibit strong purifying selection across various mammalian genomes. To determine …
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Optimization of molecular tools for high-throughput genetic screening
… efficiently knock-down any gene in the human and mouse genomes. We then went on to apply a similar approach to identify sgRNAs with increased activity. We complemented this with conservation and repair prediction to increase the likelihood of generating functional knock-outs. With these tools in …
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Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms
… tissues samples. Comparison to their human and mouse orthologues helped assess the structure and level of conservation of these genes. Our hypothesis is that the X-degenerate Y-encoded and X-encoded genes and their isoforms will exhibit expression variation between male and female across …
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… ERVs now comprises around 8–10% of the human and mouse genomes. While ERVs have lost their ability to spread from cell to cell, some have gained the ability to retrotranspose within the host genome causing mutational insertions. Moreover, accumulating evidence indicate that the highly abundant ERV …
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Mechanism and Evolutionary Origins of HIV-1 Virion Entrapment by Tetherin
… architecture are quite rare in the human and mouse genomes, and that the majority of these genes that are adjacent to each other likely arose via gene duplication. Moreover, some, but not all, PV1/tetherin-like proteins have the intrinsic ability to trap virions, when appended with a GPI …
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Evolution of Toxin Resistance in the Grasshopper Mouse: A Comparative Genomics Perspective
… I produced the first high-quality reference genomes and annotations for Onychomys species and Peromyscus eremicus (a closely related outgroup). I implemented a comprehensive pipeline to detect positive selection across genome-scale datasets and identified a promising candidate gene for pain …
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Disease susceptibility and phenotypic adaptations as seen through the lens of comparative functional genomics
… induced liver carcinogenesis across four mouse species. Here, I leverage whole-genome sequencing and RNA-seq experiments of hundreds of liver tumours to comprehensively characterise mitochondrial genomes (mtDNA) across four mouse species with distinct cancer susceptibility and progression. …
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Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
<p>About 8 and 10 percent of the human and mouse genomes, respectively, are comprised of sequences of retroviral origin. Occasional infection of germ line can lead to integrated retroviral genomes being vertically inherited as host alleles. During thousands to millions of years, some of these …