Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"mouse embryonic development"”.
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Mesoderm diversification during mouse embryonic development
During early mouse embryonic development, a single cell, the fertilised egg, will give rise to a wide range of cell types that become specialised at a functional and molecular level. Gastrulation and early organogenesis are two of the most critical events during these early stages, when pluripotent …
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Characterisation of the role of Sox4 in mouse embryonic development
… Many proteins, in pathways critical for correct embryonic patterning, are thus also identified as playing a role in aspects of heart development. A developmental role for Sox4 has been shown in mouse cardiogenesis, as apparent by the phenotype of two published alleles. Both null and conditional …
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The Effects of Propofol, Sodium Pentobarbital, and Ketamine Hydrochloride on <i>In Vitro</i> Mouse Embryonic Development
… during non-obstetric surgery in the US,1-4 and embryonic effects of general anesthesia are of particular interest in laboratory research and veterinary medicine. The mouse system is used to screen potential toxic effects of anesthetics used in egg retrieval for <em>in vitro</em> fertilization …
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The developmental function of Pax7 : chromatin-immunoprecipitation discovery of Pax7 target genes
Pax7 plays critical roles in development of brain, spinal cord, neural crest and skeletal muscle. As a sequence-specific DNA-binding transcription factor, the direct functional role played by Pax7 during development is the selection of target genes. To date, an accurate description of the function …
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Contribution of Lsh to DNA methylation reprogramming in embryonic stem cell, epiblast stem cell and embryoid body model systems
… global reprogramming during early mammalian embryonic development, resulting in almost complete erasure of the mark after fertilisation of the zygote. Genome-wide patterns of DNA methylation are subsequently re-established in the implanting blastocyst by de novo DNA methyltransferases Dnmt3a …
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The Role of the X-chromosomal Porcupine Homolog Gene in Mouse Development
… signaling pathways that are required for embryonic development as well as tissue homeostasis in adults. The X-chromosomal Porcn gene encodes a membrane-bound O-acyl transferase that is required for the acylation of all 19 WNT ligands encoded in the mammalian genome. Non-acylated WNTs fail …
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Identifizierung und Charakterisierung von Pkhd1, dem Maus-Ortholog des humanen ARPKD-Gens, sowie Erstellung und Analyse einer Pkhdl mutierten Maus
… very similar properties to its human orthologue. Mouse Pkhd1 extends over approximately 500 kb of genomic DNA and includes a minimum of 68 exons. The longest ORF encodes the 4059-amino acid protein polyductin, predicted to have multiple IPTs and PbH1 repeats and a single membrane spanning domain. …
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Computational reconstruction of mouse development using single cell transcriptomics
… of cell types across species, organs and developmental processes. The rapid development of technologies, protocols and computational methods reflects a highly dynamic field over constant improvement. Particularly for Developmental Biology, being able to study at single-cell level and over …
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Role Of Maternal Sin3a In Reprogramming Gene Expression During Mouse Preimplantation Development
In mouse, the maternal-to-zygotic transition entails a dramatic reprogramming of gene expression during the course of zygotic genome activation, which is essential for continued development beyond the 2-cell stage. Superimposed on zygotic genome activation and reprogramming of gene expression is …
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Bovine Pre-gastrulation Development and the role Of Rauber's Layer
… The majority of total combined foetal and embryonic loss is sustained between the bovine blastocyst hatching at Day 8 and the onset of gastrulation after Day 14. Post hatching, the bovine embryo develops a morphological architecture which is very different to the mouse, with a flat epiblast …
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Eomes Directs the Formation of Spatially and Functionally Diverse Extra-Embryonic Mesoderm Derived Tissues
During mouse embryonic development, the first mesodermal cells to originate at the posterior primitive streak will give rise to the extra-embryonic mesoderm (ExEM). These cells will contribute to key tissues supporting the development of the embryo, including the amnion, chorion, yolk-sac, and …
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Computational analyses of non-canonical architectural and structural features associated with alternative splicing
… profiling technologies and computational method development have enabled widespread identification of non-canonical splicing features. Non-canonical splicing is highly associated with dynamic splicing regulation, and occurs most prevalently in neuronal tissues. In this present work, I have …
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The roles of DPPA2, DPPA4 and SMARCA5 in mouse zygotic genome activation, epigenetic reprogramming and development
… activation of the newly reprogrammed embryonic genome. All these complex processes constitute the maternal to zygotic transition (MZT), which is accompanied by the global epigenetic reprogramming of the embryo. In this dissertation, I focus predominantly on the epigenetic factors that …
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Discovery of miRNA-regulated processes in mammalian development
… are also ubiquitously expressed in a variety of embryonic and adult tissues. Given these observations, we have sought to address the challenge of determining which cellular and biological processes that miRNAs might regulate in different cell types and tissues. First, we have developed methods to …
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Mechanisms of Oct4 in the entry to, maintenance of, and exit from pluripotency
… to different lineages. Prior to implantation, mouse epiblast cells enter the pluripotent naïve state, which can be captured in vitro in the form of embryonic stem cells. These cells are characterized by a capacity for indefinite self-renewal, and the ability to re-enter normal development upon …