Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"mouse development"”.
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Mouse Development and Coffee
No abstract prepared.
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Role of Raf family members in mouse development
Raf Proteine sind Serin/Threonin Kinasen, die als zentrale Elemente des Ras, Raf, Mek, Map Kinase Wegs, an der Weiterleitung von extrazellulären Signalen von der Zellmembran zu nukleären Effektoren beteiligt sind. Auf diese Weise kontrollieren sie elementare Prozesse wie Proliferation, …
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Dact Family Molecules In Wnt Signaling In Mouse Development
… and these show unique expression patterns in the development of the mouse. A mouse mutant lacking the Dact1 gene has been constructed. Despite expression of this gene in patterns suggesting roles in somitogenesis and neuronogenesis, Dact1 mutant mice are caudally truncated due to defective …
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Computational reconstruction of mouse development using single cell transcriptomics
… of cell types across species, organs and developmental processes. The rapid development of technologies, protocols and computational methods reflects a highly dynamic field over constant improvement. Particularly for Developmental Biology, being able to study at single-cell level and over …
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DAPK3 Suppresses Mammary Acini Morphogenesis and is Required for Mouse Development
… and generated a constitutive DAPK3 knockout mouse. Using the MCF10A 3D morphogenesis model we identified that loss of DAPK3 through lenti-viral mediated knockdown accelerates MCF10A acini proliferation and apoptosis while maintaining acini polarity relative to negative control. Furthermore, …
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Transgenic use of SMAD7 to suppress TGFß signaling during mouse development
… essential roles in various aspects of normal NCC development. However, it remains unclear what role Smad7, a negative regulator of TGFβ superfamily signaling, plays during development and moreover what the spatiotemporal effects are of combined suppression of TGFβ superfamily signaling during NCC …
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The Role of the X-chromosomal Porcupine Homolog Gene in Mouse Development
… pathways that are required for embryonic development as well as tissue homeostasis in adults. The X-chromosomal Porcn gene encodes a membrane-bound O-acyl transferase that is required for the acylation of all 19 WNT ligands encoded in the mammalian genome. Non-acylated WNTs fail to be …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
… role of the activating E2Fs in vivo using mutant mouse models. It demonstrates that E2F3 is essential for viability in a strain dependent manner. E2f3 animals die at three distinct time points from cardiac etiologies. The embryonic and neonatal lethality of these animals is consistent with …
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Characterization of Tuba, a novel Ena/VASP ligand, and function of Ena/VASP proteins in mouse development
… the role of EnaNASP proteins in vertebrate development. Characterization of the EVL locus revealed a new EVL isoform. A protein interaction screen for new EnaNASP ligands produced Tuba, a novel scaffold protein that associates with EnaNASP proteins in vivo. Tuba is a unique guanine …
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A lentiviral system for RNAi transgenesis and the Ena/VASP triple-knockout defines neuronal and non-neuronal functions in mouse development
Mammalian development extends and exploits signaling pathways that function exclusively in axon guidance in lower organisms. This emerging paradigm employs complex expression patterns of expanded protein families to achieve the complexity and specificity required in mammalian development. For …
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Quantitative pharmacoproteomics investigation of anti-cancer drugs in mouse. Development and optimisation of proteomics workflows for evaluating the effect of anti-cancer drugs on mouse liver
… in pre-clinical and clinical stages of drug development. The main aim of this research is to apply comparative proteomics studies on livers from male and female mice xenograft models treated with major anti-cancer drugs (5-flourouracil, paclitaxel, cisplatin, and doxorubicin) and CYP inducer, …
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Exploring functional significance of asymmetric DNA methylation in early mammalian development
… It is also crucial for correct embryonic development and the differentiation of embryonic stem cells (ESCs) into diverse cell types. Although in mammals DNA methylation occurs predominantly in the symmetric CG context, it has been shown that certain cell types and tissues (ESCs, oocytes, …
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Role Of Maternal Sin3a In Reprogramming Gene Expression During Mouse Preimplantation Development
In mouse, the maternal-to-zygotic transition entails a dramatic reprogramming of gene expression during the course of zygotic genome activation, which is essential for continued development beyond the 2-cell stage. Superimposed on zygotic genome activation and reprogramming of gene expression is …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… germ layers are generated during vertebrate development. Nodal ligands, which form a subgroup of the Transforming Growth Factor β (TGFβ) superfamily, regulate the expression several transcription factors implicated in gastrulation. Among these are the paired-like homeodomain transcription …
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PHENOTYPIC AND MOLECULAR CHARACTERIZATION OF A NOVEL P63ALPHA;KO MOUSE MODEL
… family member, plays a crucial role in embryonic development of stratified epithelia where it can function either as an activator or a repressor. In the epidermis, p63 is a master regulator of epidermal gene expression and is crucial for cell proliferation, cell adhesion and stratification. Here …
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The effect of brain-specific VEGF-C deletion on vascular morphology in the brain and skull
… is expressed in gametes or too early during mouse development, which could be the case in our experiments. Thus, at present, we can conclude that the VEGF-C deletion did not affect blood vessels in the CNS, but we cannot yet be sure if VEGF-C deletion in neuronal and glial cells affects the …
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… First, I investigated the role of RNF31 in mouse development with RNF31 knockout mouse. RNF31 deletion resulted in embryonic lethality of mouse around 8.5 days. Second, I examined the direct regulation of apoptosis by linear ubiquitination and RNF31. RNF31 inhibited TNF-α induced apoptosis …
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Functional analysis of the Argonaute family proteins during early embryonic and germ cell development in the mouse
… siRNA and miRNA silencing pathways in several developmental processes. Phosphorylation of serine 388 of murine protein is dependent on the MK2 and Akt/PKB pathways and regulates Ago2 localization. I created a nonphoshorylatable Ago2S388A allele to study this phosphorylation event during mouse …
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