Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"mouse ESC"”.
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The Functions of Setd5 and Mir-221 In Embryonic Stem Cell Differentiation
<p>Embryonic stem cells (ESCs) are a widely used model system to study cellular differentiation because of their pluripotent characteristics, and ESC differentiation is an epigenetic process. In an effort to identify a new epigenetic factor that is required for ESC differentiation, the function of …
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CROSSTALK BETWEEN PRC1 AND PRC2 IN INTESTINAL LINEAGE COMMITMENT AND CELL IDENTITY
… been deeply explored in embryonic stem cells (ESC), but remains poorly described in an in vivo context. Taking advantage of Cre-dependent conditional knockout mouse models targeting distinct Polycomb activities in the intestinal epithelium, the present work proposes to characterize the …
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Downregulation of reproductive homeobox gene 6 (RHOX6) interferes with male germ cell differentiation
… has been discovered on the X chromosome of the mouse. Because of their selective expression in reproductive organs, they are named Reproductive homeobox genes on the X chromosome (Rhox). Rhox6, a member of the Rhox family, is expressed in primordial germ cells (PGCs) in the developing gonad and …
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Cell-to-cell variability and culture conditions during self-renewal reversibly affect subsequent differentiation of mouse embryonic stem cells
… factors governing embryonic stem cell (ESC) pluripotency and differentiation. This may be a source of heterogeneity resulting in mixtures of cell types in differentiated populations despite efforts to control the differentiation conditions and the use of a clonal starting population. In …
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Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
… Due to the potential for embryonic stem cells (ESCs) to provide a variety of tissues for use in regenerative medicine, there has been great interest in the identification of factors that govern the differentiation of ESCs into specific lineages. Much of this research builds on previous studies …
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Mechanisms of Oct4 in the entry to, maintenance of, and exit from pluripotency
… to different lineages. Prior to implantation, mouse epiblast cells enter the pluripotent naïve state, which can be captured in vitro in the form of embryonic stem cells. These cells are characterized by a capacity for indefinite self-renewal, and the ability to re-enter normal development upon …