Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"motorneuron"”.
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS
… (NMDs) are characterized by the degeneration of motorneurons and/or associated skeletal muscles, and reduced BDNF is implicated in NMDs. Using Cre-Lox gene recombination technology our lab generated transgenic mice in which the BDNF gene was knocked out of skeletal muscle. We hypothesized that …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN DERIVED NEUROTROPHIC FACTOR IN THE MAINTENANCE OF MOTOR NEURON MITOCHONDRIAL POPULATIONS
… junction and, as a consequence, leave motorneurons susceptible to dysfunction. A potential origin of progressive pathology may be a reduction in brain-derived neurotrophic-factor (BDNF) signaling at the motor unit. We have shown that mice deficient in skeletal muscle-synthesized BDNF …
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Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… plasticity and neurotransmission in motorneurons at the Drosophila neuromuscular junction (NMJ). However the mechanisms that establish BMP pathway directionality and diversify pathway action in motorneurons remain elusive. In this thesis, I describe a novel regulator of the BMP …
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Dscam Switches Slit Repulsion To Mild Attraction Via Robo Receptors
… slit-N transgenes have differential effects on motorneuron innervation of muslces that are mediated by Dscam. Overexpression ofslit-FL and slit-N at the CNS midline in a robo mutant background leads to anincrease in axon attraction to the midline. We interpret this result as evidencethat Slit …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
… p3 fate at the expense of floor plate at motorneuron fates. Further understanding of Notch and Shh interaction was achieved by using cell based assays with mouse and chicken fibroblast cells, NIH3T3 and DF1 respectively, well-established in vitro models for studying Shh signalling. It was …
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Profiling the inherent vulnerability of motor neuron subtypes
Motorneuronkrankheiten sind eine heterogene Gruppe von Störungen die in einer selektiven Degeneration der oberen und unteren Motorneurone (MN) resultieren. Die genauen Ursachen für Motorneuronkrankheiten sind kaum verstanden und Behandlungen der Krankheiten begrenzen sich zurzeit auf eine Milderung …
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AR-A IPSCS: GENERATION OF AN ADVANCED CELLULAR MODEL TO INVESTIGATE A NOVEL THERAPEUTIC APPROACH FOR SBMA
Spinal and Bulbar Muscular Atrophy (SBMA) is a rare, highly disabling, neurodegenerative disease that unfortunately still lacks an effective treatment to date. Patients affected by SBMA present muscular impairment, characterized by cramps and muscle twitching in the early stages and by difficulty …