Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"motor symptoms"”.
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Evaluating the relationship between motor symptoms and Levodopa dosage in Parkinson’s disease
… This study evaluated the relationship between PD motor symptoms, measured through the MDS-UPDRS Part III, and Levodopa Equivalent Daily Dosage (LEDD), measured with daily Sinemet immediate-release dosages. The intent of this study was to find commonalities between patients to provide more concrete …
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Examining the Links Among Motor Symptoms in Hyperfunctional Voice Disorders, Auditory Discrimination, and Auditory-Motor Function
… Recent evidence suggests impaired auditory-motor function may be a factor in the development or evolution of hyperfunctional voice disorders (HVDs), the most common category. The series of studies outlined in this dissertation form a program of research that focused on further describing the …
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Non-motor symptoms in the aav-α-synuclein rat model of Parkinson’s disease: exercise as a therapeutic intervention
… (PD) is no longer primarily classified as a motor disorder due to the emergence of a number of non-motor symptoms (NMS) of the disease. These NMS are highly prevalent and greatly affect the quality of life of patients with PD. Thus, an animal model that replicates these symptoms is greatly …
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Neuropathological role of alpha-synuclein: major contribution of inflammation in the evolution of both motor and non-motor symptoms of Parkinson’s disease
… of inflammation to the neuropathology of motor symptoms has been ascertained, its role in non-motor symptoms is still under-investigated, particularly in relation to cognitive disturbances. Here, we targeted inflammation in PD by testing the immunomodulatory imide drug (IMiD) Pomalidomide …
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Sintomi non motori e disautonomia cardiovascolare in pazienti sardi affetti da malattia di parkinson con e senza mutazioni del gene LRRK2
… disease (PD) is commonly described as a motor disorder, non-motor symptoms and cardiovascular dysautonomia are important factors of disability and impaired quality of life in PD patients. To date, the definite correlation of cardiovascular symptoms with motor and other non-motor symptoms …
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From Gut to Brain - αSynuclein pathology spreading in a new transgenic mouse model
… αSynuclein (αSyn) and presence of characteristic motor symptoms are cardinal features of PD. The onset of PD motor symptoms is however preceded by non-motor symptoms that can start decades earlier. These may be associated with initiation of αSyn pathology in the peripheral nervous system, more …
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Targeting neurodegenerative phenotypes and mitochondrial dysfunction in a Drosophila Melanogaster model of Parkinson’s Disease
… substantia nigra part of brain, which leads to motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms includes mood disorders, sleep disturbances, and autonomic dysfunction. Mitochondrial dysfunction, particularly involving Complex I of the electron transport …
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Progress Towards Development Of Multifunctional, Dopamine D2/d3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease
… in the nigrostriatal pathway and ensuing loss of motor function. Common symptoms of PD include resting tremor, muscular rigidity, bradykinesia (slowness and decreased amplitude of movement), along with postural instability and cognitive psychiatric complications. PD affects 1% of the population ¡Ý …
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Therapeutic strategies of Parkinson's disease: Alternative dopamine replacement and potential drug targets
… Parkinson's disease (PD) first starts with non-motor disturbances and then slowly progresses to mild-to-moderate motor deficits, ultimately inflicting severe movement impairment and cognitive decline. Dopamine deficiency resulting from dopaminergic neuronal degeneration in substantia nigra (SN), …
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Mechanisms of Deep Brain Stimulation for the Treatment of Parkinson's Disease: Evidence from Experimental and Computational Studies
… brain stimulation (DBS) is used to treat the motor symptoms of advanced Parkinson's disease (PD). Although this therapy has been widely applied, the mechanisms of action underlying its effectiveness remain unclear. The goal of this dissertation was to investigate the mechanisms underlying the …
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From effects to affect: the multidimensional impact of dancing with Parkinson’s
… condition characterized by a variety of motor and non-motor symptoms that can lead to increasing disability and complex psychosocial challenges. While medical treatments can help people living with Parkinson’s to manage symptoms, they do not fully address many challenges associated with …
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Effect of Levodopa on EEG Connectivity in Parkinson's Patients
… with Parkinson’s disease (PD) to alleviate their motor symptoms. However, its long-term use can cause adverse side effects, including involuntary motor movements. We studied 16 PD patients before and after taking Levodopa based on resting-state electroencephalography (EEG) recordings to determine …
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Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons
… Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. This is caused by progressive degeneration of …
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Cell proliferation and metal accumulation in the subventricular zone and olfactory bulb in Parkinson’s disease
… disease (PD) is characterised by four main motor symptoms: resting tremor, rigidity, bradykinesia, and postural instability. However, over 95% of PD patients also report a decline or total loss in the ability to smell, which often occurs years before any motor symptoms develop. Possible …
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Longitudinal Perspective of Participation in a Double Blind Placebo Surgery Trial
… neurological disorder that causes both motor symptoms and non-motor symptoms in individuals. Overall, PD impacts the physical, emotional and social functioning in the lives of those impacted by the disorder. In 2001, Freed et al. investigated the effects of fetal tissue transplantation …
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Gastrointestinal dysfunction in Parkinson’s disease: Interactions between the gut, immune markers and disease outcome
… it is also associated with important non-motor symptoms. Gastrointestinal dysfunction in PD (GID-PD) may include weight loss, dysphagia and sialorrhoea. Constipation, the most prominent feature, is often present before the onset of motor symptoms and has a significant impact on quality of …
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Human Embryonic stem cell-derived A9 dopaminergic neurons as a model and therapy for Parkinson's disease
… in the UK. While PD presents as a combination of motor and non-motor symptoms, the motor dysfunction observed in PD represents one of the most profound and debilitating clinical features. Although there are effective pharmacological and surgical options for those living with PD, all current …
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Differential Effects of Parkinsonian Toxins and L-DOPA on Locus Coeruleus and Substantia Nigra Neurons: Implications for Parkinson’s Disease
… is traditionally known for its characteristic motor symptoms, caused by degeneration of dopamine (DA)-producing neurons of the Substantia Nigra pars compacta (SNc). However, PD patients also suffer from many non-motor symptoms (NMS; eg. sleep disturbance, autonomic dysfunction, depression and …
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READING THROUGH THE BUILDING BLOCKS OF THE GENOME: EXONIC VARIATION IN PARKINSON'S DISEASE
… dopamine deficit can alleviate the major motor symptoms and enhance the patients quality of life, but finally are not able to halt or slow down disease progression. Therefore, there is an urgent need to better understand the molecular mechanisms underlying the physiopathology of PD and to …
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Social Cognition in Disorders of the Basal Ganglia
… and Tourette’s Syndrome, exhibit characteristic motor symptoms and less obvious cognitive deficits. These deficits can be understood with reference to the model of cortico-striato-thalamo-cortical circuitry proposed by Alexander et al. (1986) which highlights how the basal ganglia can affect the …
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