Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"motor neuron degeneration"”.
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Investigating the role of eEF1A2 in motor neuron degeneration
… has been implicated in disease states such as motor neuron degeneration and cancer. Two variants of eEF1A are found in mammals, named eEF1A1 and eEF1A2. These two variants are encoded by different genes, produce proteins which are 92% identical but have very different patterns of expression. …
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Unraveling the molecular mechanism underlying ALS-linked astrocyte toxicity for motor neurons
… which is characterized by a progressive loss of motor neurons. Studies in chimeric and conditional transgenic mutant SOD1 mice indicate that non-neuronal cells, such as astrocytes, play an important role in motor neuron degeneration. Consistent with this non-cell autonomous scenario are the …
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The role of apoptosis in <i>in vitro</i> and <i>in vivo</i> models of amyotrophic lateral sclerosis
… (ALS) is a neurodegenerative disease leading to motor neurons death. Although many studies were performed, the aetiology and the features of cellular death occurring in ALS are poorly understood, and studies carried out from autoptic samples do not allow to clarify early events occurring in ALS. …
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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies
… Lateral Sclerosis (ALS) is an always lethal motor neuron disease with unknown pathogenesis. Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) have limited neuroprotection in some models of motor neuron degeneration. However the direct effect of Hsp90 inhibition on motor …
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The Role of Vps54 in Drosophila melanogaster Neuronal Development and Age Progressive Neurodegeneration
… mutation in Vps54. This mutation causes neurodegeneration and is subsequently used as a model for human motor neuron disease. Presently, it is unclear how disruption of GARP complex function leads to motor neuron degeneration. To better understand the role of Vps54 in motor neuron development, …
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Proteomic Profiling of Animal Models of Myotonia and Motor Neuron Disease
… transformation from slow-to-fast by decreased motor nerve activity, hypogravity, physical inactivity and in diseased states. Similarly muscle transformation from fast-to-slow can be evoked by increased muscle nerve activity or exercise. The multitude of protein changes that has been identified …
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The pathophysiology of spinal muscular atrophy
… the disease course and pathophysiology of motor dysfunction in spinal muscular atrophy (SMA) using clinical, epidemiological, neurophysiological and genetic studies. Natural history studies confirmed the unique clinical course, atypical for a neurodegenerative disease, in which progression …
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The pathogenesis of murine retroviral-induced noninflammatory spongiform polioencephalomyelopathy: Neuronal degeneration is indirectly mediated by resident microglial cells
… with non-inflammatory spongiform lesions and motor neuron degeneration within selected nuclei of the brainstem and ventral horns of the cervical and lumbar enlargements of the spinal cord. To determine the biologic basis of ts1 MoMuLV neurovirulence, newborn CFW/D mice were inoculated with …
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Developmental biology of heterodera glycines (soybean cyst nematode) and other plant - parasitic nematodes
… that stylet protractor muscles and the primary motor nervous system of H. glycines J2s continue to develop until late in pre-hatch J2s, suggesting their requirement in hatching. Following infection and the establishment of a feeding site, sedentary nematodes females (H. glycines, Meloidogyne …
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Commonalities between SMA and ALS: investigation of ribosome heterogeneity and translational defects
… pathologies, characterized primarily by lower motor neuron degeneration, are caused by mutations in genes encoding for ubiquitously expressed RBPs with common functions in mRNA metabolism. Recent studies have revealed that the survival motor neuron protein (SMN), which is involved in SMA, is a …