Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 134 for “"motor neuron"”.
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Profiling the inherent vulnerability of motor neuron subtypes
Motorneuronkrankheiten sind eine heterogene Gruppe von Störungen die in einer selektiven Degeneration der oberen und unteren Motorneurone (MN) resultieren. Die genauen Ursachen für Motorneuronkrankheiten sind kaum verstanden und Behandlungen der Krankheiten begrenzen sich zurzeit auf eine Milderung …
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Investigating the role of eEF1A2 in motor neuron degeneration
… has been implicated in disease states such as motor neuron degeneration and cancer. Two variants of eEF1A are found in mammals, named eEF1A1 and eEF1A2. These two variants are encoded by different genes, produce proteins which are 92% identical but have very different patterns of expression. …
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The Dual Role of Notch Signaling During Motor Neuron Differentiation
… spinal cord, Olig2+ progenitors in the motor neuron progenitor domain give rise to an impressive array of motor neurons, oligodendrocytes and astrocytes. Motor neurons are further diversified into motor columns and pools based on cell body settling position, general axonal trajectories, …
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
Motor neuron degenerative diseases (MNDs) are a large group of genetically and clinically heterogeneous life-limiting disorders. MNDs are characterised by the progressive degeneration of upper and/or lower motor neurons. Unfortunately, there are currently no universal biomarker assays or …
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Proteomic Profiling of Animal Models of Myotonia and Motor Neuron Disease
… transformation from slow-to-fast by decreased motor nerve activity, hypogravity, physical inactivity and in diseased states. Similarly muscle transformation from fast-to-slow can be evoked by increased muscle nerve activity or exercise. The multitude of protein changes that has been identified …
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Phosphoglycerate kinase 1 as a therapeutic target in motor neuron disease
… features in neurodegenerative conditions like motor neuron disease (MND) and supporting cell energy production is an attractive strategy to improve the resilience of neurons to disease pathology. Phosphoglycerate kinase 1 (PGK1) is a key enzyme in the first ATP-producing step in the glycolysis …
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Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… it specifies the fates of oligodendrocytes and motor neurons as well as proliferation of neural precursors and control of axon outgrowth. To explore the roles of Shh in neuronal differentiation, we utilized embryonal carcinomal P19 cells as an in vitro model system. We overexpressed Shh in P19 …
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Proteomic Profiling of Animal Models of Motor Neuron Disease and Muscular Dystrophy
… diseased muscle groups from animal models of motor neuron disease and XQlinked muscular dystrophy is presented, in addition to motor neuron disease associated globozoospermia. This research has shown that both gel electrophoresis based and/or liquid chromatography for largeQscale protein …
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Investigating the Impact of Biochemical and Mechanical Stimuli on Motor Neuron Growth
… effects of biochemical and mechanical stimuli on neuronal growth to push the field of neuromuscular systems forward. We utilized optogenetic stimulation to emulate the biochemical effects and a magnetic fibrin platform to isolate the mechanical effect. To develop our magnetically actuatable …
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Human leptomeninges; inflammatory roles in motor neuron disease, and their potential in gene therapy
The leptomeninges, comprising the inner two layers of the meninges, were traditionally recognised solely for their protective role in the central nervous system (CNS), yet are now understood to be involved in numerous physiological functions including modulation of neurological disorders. …
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Endothelin-1 is over-expressed in Amyotrophic Lateral Sclerosis and induces Motor Neuron cell death
… disorder characterized by progressive loss of motor neurons (MNs) and astrogliosis. Recent evidences suggest that factors secreted by activated astrocytes might contribute to degeneration of MNs. We focused on endothelin-1 (ET-1), a peptide which is strongly up-regulated in reactive astrocytes …
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Non-Parametric Analyses of the Regulatory Roles of LINE-1 Retrotransposons during Motor Neuron Differentiation
Background: Repetitive elements make up a large portion of eukaryotic genomes, constituting two-thirds of human genome. Although their functional importance were recognized as early as 1950s, study of their functions is stagnated despite the advancements in next-generation sequencing due to …
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THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE
… factor (BDNF) is a neurotrophin essential to neuron health and maintenance in both the central nervous system and periphery. It acts as a positive feedback system for the body’s motor neurons and the muscles they innervate, strengthening the synapse between them. Skeletal muscle-synthesized …
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Motor neuron output in the crustacean cardiac ganglion is organized and maintained by homeostatic conductance relationships
Generating appropriate and functional neuronal output is a matter of fundamental importance to nervous systems across species and phyla. Potential perturbations to a neurons intrinsic excitability alone include Hebbian style plasticity, ion channel turnover and neuromodulation. With these dynamic …
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Biochemical and Functional Characterization of Novel RNA-binding Proteins Interacting with SMN in Motor Neuron-derived Cells
… from the loss and/or degeneration of alpha motor neurons in the lower part of the spinal cord. With ~ 1 in 6000 live births per year being affected, this disease is the second leading cause of infant death and is caused by the loss or decrease of the Survival of Motor Neuron protein (SMN). …
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UPPER MOTOR NEURON BURDEN IN AMYOTROPHIC LATERAL SCLEROSIS: CLINICAL AND IMAGING FEATURES, AND THE ROLE OF IRON METABOLISM
… cui la degenerazione del primo e del secondo motoneurone sono coinvolte in modo selettivo. Un elemento di difficoltà nella diagnosi e nel definire una terapia efficace è la considerevole eterogeneità nella presentazione clinica, in assenza di marcatori biologici specifici, dovuta anche ai …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN DERIVED NEUROTROPHIC FACTOR IN THE MAINTENANCE OF MOTOR NEURON MITOCHONDRIAL POPULATIONS
… junction and, as a consequence, leave motorneurons susceptible to dysfunction. A potential origin of progressive pathology may be a reduction in brain-derived neurotrophic-factor (BDNF) signaling at the motor unit. We have shown that mice deficient in skeletal muscle-synthesized BDNF …
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The role of specific voltage-activated and calcium-activated potassium currents in shaping motor neuron firing output during rhythmic motor activity
… are necessary for survival. Though in many cases motor neurons (MNs) themselves do not generate the basic motor rhythm, research suggests that the intrinsic properties of MNs may shape the timing of the final motor output. In particular, potassium (K⁺) currents can affect MN excitability and …
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CHARACTERIZATION OF THE ROLES OF MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR AND PRESYNAPTIC TYROSINE RECEPTOR KINASE B IN MOTOR NEURON AXONAL TRANSPORT
… essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream …
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