Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"motoneurons"”.
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Modulation of Hypoglossal Motoneurons by Nitric Oxide
… sleep results in disfacilitation of hypoglossal motoneurons, increased airway resistance and contributes to the development of OSA (Horner R. L., 2007). However, a fundamental question of sleep medicine that remains unresolved is what mechanisms help maintain airway patency during sleep? A …
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Frog Spinal Motoneurons: Their Supraspinal Synaptic Input and Anatomical Localization
… and for recording intracellularly from lumbar motoneurons in this preparation. Fibers in the contralateral and ipsilateral lateral funiculi of the spinal cord which originate at or above the calamus scriptorius were found to produce EPSPs in flexor and extensor motoneurons innervating the …
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A novel therapy to regain control of spinal motoneurons in stroke survivors
… method for regaining functional control of motoneurons.
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Mechanisms of Estrogen-Dependent Dendrogenesis in Motoneurons of the Spinal Nucleus of the Bulbocavernosus
Early hormone exposure is required for the development of many neural structures across a variety of species. The spinal nucleus of the bulbocavernosus (SNB), a motor nucleus that controls erections and ejaculations in male rats, requires gonadal hormones for typical development. While the …
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Axo -Dendritic Midline Guidance, Early Polarity and Dendritic Development in Embryonic Motoneurons of Drosophila Melanogaster
While it has been observed that neurons are cells that are polar and connected, the growing work in dendritic guidance leads to the questions regarding the possibility that these two developmental endpoints are interrelated.
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Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
… of Ib tonic or Is phasic glutamatergic motoneurons that co-innervate postsynaptic muscles at Drosophila neuromuscular junctions (NMJs). After identifying drivers for each neuronal subtype, I performed ablation or genetic manipulations to alter neuronal activity and examined the effects …
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Developmental Nicotine Exposure And Its Effects On Morphology And Electrophysiology Of Hypoglossal Motoneurons In The Neonatal Rat
… the structure and function of the hypoglossal motoneurons (XIIMNs) over the first few days post-parturition. Previous work in XIIMNs demonstrated an increase in cellular excitability (Pilarski et al., 2011), alterations in synaptic transmission among respiratory-related neurons (Wang et al., …
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The Role of Raf-mediated Signalling Pathways for Motoneuron
… functions of the different Raf kinases in motoneurons during development, the expression, distribution and subcellular localization of Rafs in the spinal cord and the facial nucleus in brainstem of mice at various embryonic and postnatal stages were investigated. Moreover, we have …
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Analysis of the Mechanisms and Principles of Neural Development in the Drosophila
… features of synaptic formation. Examining the motoneurons that formed different types of boutons showed variances in the innervation patterns produced by the motoneurons. The motoneurons that developed the large synapses (type Ib) innervated one target, while the motoneurons that formed the …
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MODELLING RIBOFLAVIN TRANSPORTER DEFICIENCY (RTD) USING IPSC-DERIVED MODELS TO TEST GENE THERAPY EFFICACY
… we developed three disease models through 2D motoneurons, spinal cord and retinal organoid differentiation of RTD patients-specific induced pluripotent (iPSC) line carrying several mutations in SLC52A2 gene. First, we tested gene replacement therapy on RTD type 2 patient-derived motoneurons …
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EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
… and functional deficits in nearby surviving motoneurons, and that treatment with testosterone attenuates these structural and functional deficits. In this dissertation, I establish that exercise following partial motoneuron depletion is similarly neuroprotective to motoneurons, via a …
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Zytosolisches Calcium in murinen Hirnstamm-Motoneuronen wird differenziert von Mitochondrien reguliert
… in Scheiben des Maushirnstamms. Bei facial motoneurons (FMNs), die vulnerabel gegen ALS sind, bewirkten Störungen des mitochondrialen elektrochemischen Potentials durch bath application des mitochondrialen uncoupler FCCP (Carbonyl cyanide 4-trifluromethoxyphenylhydrazone) eine signifikante …
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The Role of Orexin in Modulating Locomotion
… effect of orexin onto isolated networks of the motoneurons showed a considerable increase in the firing rate of motoneurons, further suggesting orexin’s involvement in the locomotor circuitry.
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The regulation of motoneuron survival in the tobacco hornworm, Manduca sexta
… 20-hydroxyecdysone, and in the case of the MN-12 motoneurons, by actions exerted by neighboring ganglia.
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… into choline acetyltransferase (ChAT) motoneurons in vitro and after transplantation into the rodent spinal cord in vivo. However, the mechanisms surrounding FHL-induced motoneuron differentiation of hNSCs are unknown. Thus, the overall goal for this thesis was to further understand the …
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ELECTROPHYSIOLOGICAL ANALYSIS OF THE RECURRENT RENSHAW CIRCUIT
… other interneurons, which, in turn, project to motoneurons. The project describes the use of a relatively new data processing technique, spike-triggered averaging, to study the effects of the single impulses of single motor axons on the postsynaptic activity of single motoneurons which were …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… Further examination of the aCC, RP3, and RP2 motoneurons revealed that the midline mutants commissureless, netrin, frazzled and roundabout disrupt dendritic growth cone guidance at the CNS midline. Specifically, frazzled and roundabout act cell autonomously to mediate dendritic attraction and …
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
… signaling. Overexpression of Perlecan in motoneurons cannot rescue synaptic retraction phenotypes. Similarly, removing Perlecan specifically from neurons, glia, muscle, fat body, or hemocytes does not cause synaptic retraction, indicating the protein is secreted from multiple cell types …
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